Molecular and Cellular Physiology

At the Feng Lab we are interested in the structure, dynamics and function of eukaryotic transport proteins mediating ions and major nutrients crossing the membrane, the kinetics and regulation of transport processes, the catalytic mechanism of membrane embedded enzymes and the development of small molecule modulators based on the structure and function of membrane proteins.

Lab overview

The communication between cells and their environment depends on a finely tuned decoding of extracellular cues into an array of intracellular signaling cascades that drive a cellular response. These signals are integrated through highly dynamic and context specific signaling networks that collectively define the phenotypic output. Given the complexity and dynamic state of signaling networks, the current understanding of their constituents and how they are spatiotemporally regulated in the cell as a result of a specific input is incomplete.

Research overview:

The @wormsenseLab at Stanford University seeks postdoctoral scholars with an interest in the genetics, biophysics, and cell biology of sensation.  In appointing postdocs, we look for curiosity, excellence in the practice of reproducible research, and the ability to lead and work in teams — learning from and teaching others.

The @wormsenseLab at Stanford University seeks postdoctoral scholars with an interest in the genetics, biophysics, and cell biology of sensation. Experience with in vivo and in vitro live imaging as well as gene-editing techniques in a genetic model organism such as C. elegans is preferred, but not essential. In appointing postdocs, we look for curiosity, excellence in the practice of reproducible research, and the ability to lead and work in teams — learning from and teaching others.

Our research lab focuses on studying the molecular mechanisms of ion channels and transporters. We use a combination of biophysical methods to probe membrane protein structure and dynamics, together with functional assays and electrophysiological analysis. Ongoing projects in our lab include:
• Examining the molecular mechanisms of chloride/proton transporters
• Developing new small-molecule probes to studying mammalian chloride channels
• Exploring the biophysics and physiology of the mammalian chloride channels

The wormsenseLab seeks to decipher the genetic, molecular and physical basis of touch sensation and its disruption by mechanical and chemical stress, such as exposure to elevated glucose in diabetes and chemotherapeutic drugs.

The Maduke laboratory at Stanford University is seeking a postdoctoral scholar to study the molecular mechanisms of chloride-selective channels and transporters.