Pathology

Chromatin regulators are highly altered in diseases. Of interest, these proteins are easily targetable by drugs. Furthermore, the plasticity of epigenetic events makes them a powerful target for new therapeutic strategies and reversion of disease phenotype. Histone and DNA modifications influence many processes including transcription, replication, genomic stability and cell division, which are altered in diseases. Therefore, understanding the molecular basis of chromatin modifiers in both normal and pathological cells could help us frame new potential biomarkers and targeted therapies.

Energy metabolism encompasses the fundamental homeostatic processes by which we regulate our energy storage and energy expenditure. Energy metabolism is highly dynamic and changes according to availability of nutrients, physical activity, or environmental conditions. Dysregulation of energy metabolism is a hallmark of many age-associated chronic diseases, including obesity, type 2 diabetes, dyslipidemias, neurodegeneration, and cancer.