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Stanford University, its Division of Pediatric Gastroenterology, Hepatology, and Nutrition (Peds GI) and the Husain Lab are seeking a highly motivated and enthusiastic Postdoctoral Fellow to join us in our study of the immunology of the pancreas. Some of the broad questions our research group is asking includes probing the deep immune subtypes that differentiate various forms, including hereditary forms, of pancreatic inflammation and whether some of these immune subtypes are druggable so as to alleviate inflammation and cancer progression in the pancreas.
The applicant must hold a PhD or MD or equivalent qualification, with training in modern techniques in immunology or a closely related discipline.
The Husain Lab is located in the beautiful new Stanford Research Park campus of Stanford University, at 1701 Page Mill. The mission statement of the Husain Lab (www.husainlab.org) is to make breakthroughs in the pancreas and beyond that benefit patients and society, through innovation, partnerships, inclusion, and integrity. The Husain Lab is embedded in the fabric of a thriving scientific community at Stanford, consisting of over 8,000 contiguous acres, with a 1.93 billion dollar annual research budget and a 28.9 billion dollar endowment. Nineteen Nobel laureates are currently members of the Stanford community as are 167 members of the National Academy of Science, among the almost 2300 faculty. There are over 2400 Postdoctoral scholars in this highly diverse environment. Another major attraction to Stanford is its emphasis on innovation and moving the needle on science. There are many perks to being at Stanford, not the least of which is the idyllic Bay Area.
We are seeking a self-motivated individual with excellent communication skills and a strong work ethic. The individual will conduct independent research as well as closely work with others and must be a great team player. The individual will work directly with immunologist Dr. Bomi Lee, PhD, and the Pancreas Immunology section, while being an integral part of the wider lab community.
More details of our work include the use of cutting edge unbiased immune analysis technologies to uncover immune mechanisms and biomarkers in acute and chronic pancreatitis, and our accomplishments have resulted in several recent publications in reputable journal.
• scRNA/TCR-seq and CITE-seq analysis of pancreatic immune cells in human chronic pancreatitis patients. Lee et al. Gut. 2021.
• CyTOF analysis in pancreatitis mouse models and human samples. Manohar et al. Gastroenterology. 2021• Single-cell immune profiling and a bulk TCR-seq in human chronic pancreatitis. Lee et al. Journal of Clinical Investigation. 2020
• Adoptive transfer studies of calcineurin signaling in pancreatitis. Wen et al. Gastroenterology. 2020.
• STING signaling in chronic pancreatitis. Qinglan and Manohar et al. Gut. 2019
• STING signaling in acute pancreatitis. Qinglan et al. Gastroenterology. 2018
• IL-22 signaling in smoking-associated pancreatic fibrogenesis during chronic pancreatitis. Xue and Qinglan et al. Gastroenterology. 2016
• PhD with training in immunology or closely related field. Previous Postdoc training is not required.
• Comprehensive understanding of scientific principles.
• Expert level knowledge and skills in field of science related to research project.
• Technical competence and passionate with cell culture and genetic editing (knockout and overexpression) techniques.
• Strong molecular and cell biology techniques, as well as experience working with mouse and human models.
• Strong general computer skills, experience with databases and scientific applications, and ability to quickly learn and master various computer programs.
• A PhD, MD or equivalent with prior relevant training in Immunology, Biology, Physiology, Biochemistry or related field.
• Optimally 5+ years of experience in molecular and cell biology, including experience in single cell sorting (FACS) and analysis.
• Experience with immunofluorescence and confocal microscopy.
• Experience with diverse clinical patient sample analysis.
• Must be technically rigorous, highly organized, and have demonstrated excellence, innovation and productivity in research.
• Able to work independently and function effectively as part of a team of physicians, students, postdoctoral fellows, and laboratory and animal technicians and staff.
• Summary of previous research experience and interest
• Three references