Interested applicants should submit by email the required application materials to Sneha Ramakrishna, Assistant Professor, Division of Hematology/Oncology, Department of Pediatrics, Stanford University School of Medicine. Email: email@example.com.
A postdoctoral fellow position is available in the laboratory of Dr. Sneha Ramakrishna in the Department of Pediatrics, Division of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine at Stanford University.
The Ramakrishna laboratory focuses on optimizing chimeric antigen receptor (CAR) T cell therapies for children with cancer by learning about the biology of these CAR T cells in patients. The lab performs multiparametric analyses on patient samples from cellular immunotherapy clinical trials and validates novel manipulatable biomarkers to optimize CAR T cell activity in patients. We utilize multi-dimensional analyses of single cell proteomics (flow cytometry/CyTOF), single cell transcriptomics (single-cell RNA-sequencing), and functional assessments (ELISA/Incucyte) of CAR T cells from patients to identify immune signatures of CAR-T success or failure in patients. Once identified, the lab explores the biological implications of these signatures and develops novel platforms to optimize CAR T cell activity with the goal of translating back to the clinic.
This position will provide the candidate with the opportunity to lead interdisciplinary research projects focused on identifying novel immune determinants of CAR T cell success or failure for children with cancer. We are looking for a highly motivated individual who has a strong background in immunology and computational experience. The successful candidate will conduct projects focused on looking at immune determinants of CAR T cell success or failure in pediatric patients, by first analyzing and integrating multidimensional datasets and then validating in a wet-lab environment.
This work is highly collaborative within the larger environment of the Stanford Cancer Cellular Therapy Team, and so the candidate is expected to engage in team science, working with other post-docs, technicians, students, and collaborating scientists.
- This position is for a candidate with a PhD in immunology (preferably), but could also be in cell biology or cancer biology.
- The candidate should have expertise in immunology and animal handling in addition to some of the following preferred laboratory techniques: cell culture, gene editing/transcription and virus transfection, flow cytometry.
- The candidate is expected to have the ability to work independently and as part of a team.
- Self-initiative and motivation, excellent communication, teamwork, data processing, written and oral presentation and problem-solving skills are desired.
- English proficiency is required.
- Curriculum vita
- Letter of interest