Please submit application directly to Dr. Kapiloff at firstname.lastname@example.org
Electrophysiology and Signal Transduction Research: There is an open postdoctoral position in the laboratory of Michael S. Kapiloff, MD, PhD, the Reinhard Family Professor at Stanford University in the Departments of Ophthalmology and Cardiovascular Medicine and a member of the Stanford Cardiovascular Institute. We are seeking to recruit a highly motivated cellular and molecular biologist with experience in electophysiology and/or live cell imaging of cardiac myocytes to study a novel signalosome that regulates cardiac hypertrophy. Research in the Kapiloff lab addresses how the formation of multimolecular protein complexes called “signalosomes” confers specificity in intracellular signaling and how these complexes are important for the function of cardiac myocytes in pathological remodeling and for the survival of retinal neurons in diseases like glaucoma. A major focus of the lab has been the mAKAP scaffold protein that coordinates crosstalk between cAMP, calcium and MAP-kinase signaling pathways and that is important for the induction of pathological myocyte hypertrophy in the heart and for neuroprotection in the eye. Other projects include the study of novel scaffold proteins for the phosphatase calcineurin and for small GTPases. Research in the Kapiloff laboratory spans the breadth of signal transduction research from biochemistry to cell biology (including live cell imaging with FRET biosensors) to in vivo animal physiology using genetically modified mouse models. In addition, basic research concepts studied in the laboratory are being applied to the development of novel gene therapy vectors for the treatment of heart failure and glaucoma.
- PhD must have been acquired no earlier than 2020.
- Strong English presentation and writing skills required.
- Record required of first author publication demonstrating skills in electrophysiology or live cell imaging using genetically encoded biosensors.
- Curriculum Vitae
- 3 letters of recommendation