Important Info
Interested applicants should submit th required application materials to Kathleen M. Sakamoto, M.D., Ph.D., Professor, Division of Hematology/Oncology, Department of Pediatrics, Stanford University School of Medicine. Email: kmsakamo@stanford.edu.
Postdoctoral fellowship or Ph.D. Research Scientist opportunity
Stanford University School of Medicine
Stanford, CA
Genomic Landscape, Signaling Pathways and Targeted Therapies for Pediatric Leukemia
Laboratory of Kathleen Sakamoto, M.D., Ph.D. (Pediatrics, BioX, Stanford Cancer Institute, Stanford ChEM-H)
Division of Hematology/Oncology/Stem Cell Transplantation & Regenerative Medicine
Department of Pediatrics
An opportunity is available for a postdoctoral fellow who is interested in pathogenesis of pediatric leukemia (CML, AML, ALL) towards a career in academics, biotechnology or pharmaceutical industry. The applicant should have a strong background in cancer biology, molecular biology, biochemistry, immunotherapy/immunology, bioinformatics, and experience working with mammalian cells and mouse models of cancer, especially leukemia. There will be opportunities to work with physicians, translational researchers, medicinal chemists, and advisors from drug companies with experience in drug development.
Leukemia cell lines, primary mouse and human hematopoietic cells, and mouse models will be used. Technologies in the lab include standard biochemistry techniques (Western blot analysis, real-time PCR, immunoprecipitations), FACs/sorting, colony assays, lentiviral and retroviral transductions, transplantation experiments, xenograft models and bioluminescence, CyTOF, bulk and single cell RNA-seq ,ChIP-seq, small molecule and shRNA/CRISPR library screening. Knowledge in bioinformatics would be helpful for single cell RNA-seq experiments. The intent of these early translational studies is to develop small molecules or peptides into drugs to treat acute leukemia. Assays to assess toxicity, metabolism, optimization, and mechanism of action of compounds will be performed.
This position is for postdoctoral fellows who have received a Ph.D. in molecular biology, cellular biology, immunology or biochemistry and have completed their Ph.D. and graduate level training within the past 3 years. Experience in drug discovery, pharmacology, and cell and animal models of leukemia or cancer are preferred. U.S. Citizenship, Green Card or Permanent Residency is not required.
Our laboratory of 10 individuals includes a Senior Scientist, postdoctoral fellows (Ph.D.), technician, and undergraduate students. Dr. Sakamoto’s research is supported by the National Institutes of Health, Leukemia and Lymphoma Society of America, Department of Defense, and Pediatric Cancer Research Foundation.
Women and underrepresented minorities are encouraged to apply.
- Ph.D.
- Curriculum vita
- Letter of interest