Open Postdoctoral position, faculty mentor Haopeng Xiao

We are a mass spectrometry and chemical systems biology lab seeking for a biologist with strong training in mechanistic characterization of biological problems. Expertise in one or more of the following fields is a BIG plus: cancer biology, molecular metabolism, protein degradation, gene editing, and animal physiology.

We are seeking a highly motivated and curious fellow who are interested in exploring the mechanisms of metabolic regulation over protein function in metabolic disease and cancer. Our lab develops cutting-edge mass spectrometry-based approaches, integrated with data science, to create comprehensive systems overviews of key questions in the field of metabolism. From these systems overviews, we identify molecular targets of significant biological and translational relevance. We then biochemically characterize the mechanisms through which these newly-identified targets modulate phenotypes in vitro and in vivo. Building on this foundation, we employ chemoproteomic approaches to develop translational strategies.

The postdoctoral fellow will be hired through Stanford Cancer Institute and will be based in Stanford Biochemistry. The fellow will perform a range of experiments, including but not limited to mammalian cell culture, PCR, protein/DNA/RNA extraction and gel electrophoresis, bacterial transformation, imaging, cloning, gene editing (such as CRISPR), small and large-scale plasmid purification, sequencing, transfection, transduction of viral supernatants into cell lines, recombinant protein preparation, and utilizing standard software (such as ImageJ, BioRad, SnapGene, etc.) to facilitate biological experiments. The fellow may also work with mice and conduct animal physiology experiments. Prior training in these techniques is required. In our lab, the fellow will receive training in mass spectrometry-based proteomics and metabolomics, as well as data science, with an emphasis on exploring biological mechanisms through both hypothesis-driven and hypothesis-free approaches.

The fellow is expected to write and submit manuscripts for peer-reviewed publication in a timely manner, as well as train and mentor graduate students and/or technicians. We will provide training in proposal writing and oral presentation of research findings. Our lab strongly supports fellows in acquiring postdoctoral and pathway-to-independence fellowships.

This position is initially for one year, with the possibility of renewal based on mutual agreement.

Screening of applications will begin immediately, and recruitment will continue until the position is filled. Initial interviews will be conducted via phone or videoconference.