Please submit applications to:
Terra Coakley (email@example.com)
The Ashley lab is seeking a postdoctoral scholar who will use CRISPR-based genome engineering technologies to develop high throughput assays of genotype-phenotype relationships in single cells. The aim of our NIH-funded project is to determine structure-function relationships for key genes associated with hypertrophic cardiomyopathy, a serious inherited disease of heart muscle that can lead to heart failure and sudden cardiac death. The scholar will work as part of an interdisciplinary team of scientists and physician-scientists whose skills include bioengineering, in vitro genome engineering, and use of patient derived induced-pluripotent stem cell (iPSC) technologies for disease modeling. The project will also involve close collaboration with multiple laboratories in the Departments of Medicine, Genetics and Bioengineering at Stanford and the Department of Chemistry and Chemical Biology at Harvard, groups who have pioneered many of the techniques we use. Candidates holding a PhD or MD-PhD with specific prior experience in genetics, genome engineering, iPSC biology and/or cardiac disease modeling will be considered strongly.
Our group is a central part of Stanford’s Center for Inherited Cardiovascular Disease. We are focused on the role of the human genome in health and disease and specifically inherited cardiovascular disease. Lab member expertise ranges from computational biology and deep learning to disease modeling at the bench, and extends to clinical applications. This allows us to seamlessly integrate hypotheses generated from large scale human genomic data with mechanistic inquiry required to pursue the underlying causes of identified associations. We are a fun, invested and diverse group and we look forward to meeting potential candidates!
PhD is required
Cover letter and CV