Candidates should submit application materials directly to Paige Collazo: firstname.lastname@example.org
The Mignot Lab at Stanford University School of Medicine, Center for Narcolepsy in the Psychiatry and Behavioral Sciences department is looking for a highly motivated, self-driven postdoctoral fellow for a Neuroimmunology Postdoctoral fellowship with T cell biology focus. This position will be working conjointly with the laboratory of Mark Davis, Chair of Microbiology & Immunology, and candidates will be selected by both labs. Our laboratory works on neuroimmune diseases that involve T cells and affect the brain. These include, narcolepsy, anti-NMDAR encephalitis, anti-LGi1 encephalitis, anti-Iglon 5 (diseases that can also be in reaction to excessive cancer immunity) and, surprisingly based on recent results, Parkinson’s and Alzheimer’s diseases. Our approach almost always starts with genetics. We are analyzing the largest GWAS samples for these diseases at the level of immune related loci such as HLA and KIR, loci which are not commonly studied by other researchers because these need special training (which we can provide). From there, we conduct HLA multimer including tetramer and dextramer studies to isolate culprit T cells and use single cell sequencing studies in blood and CSF to identify culprit T or NK cell receptor s and phenotypes. The work mostly involves peptide binding studies/predictions, tetramer/dextramer/spheromer studies and single cell RNA sequencing to isolate and characterize T cell or NK cells. Experimental protocols are all established. Our genetic findings are discovering new biology for specific diseases where the student will be asked to apply these technologies. The overarching aim is to better understand the role of adaptive and innate immune responses in neuroimmune disorders, as outlined at https://www.mignotlab.com/.
- Must have graduated from an accredited PhD program by the start of the postdoc fellowship.
- Area of research must be in immunology, with preference given to T cell or NK cell immunology. Understanding of HLA and KIR is a plus.
- Must be able to follow established protocols independently and have experience in flow cytometry, single cell sequencing, protein purification, and human cell culture.
- Demonstrated ability to work independently, self-initiative, attention to details, be dedicated, and self-motivated with a strong aptitude for team work.
- A cover letter detailed your past work and reasons for your interest in this specific position
- Curriculm Vitae
- Contact information for three professional references