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The Mackall Laboratory is seeking a creative and motivated computational immunologist to join as a Postdoctoral Fellow working within the Stanford Center for Cancer Cell Therapy at Stanford University School of Medicine
The Mackall Lab is excited to offer a Postdoctoral Fellow position with a focus on machine learning in the Stanford Center Cancer Cell Therapy at Stanford University School of Medicine. We seek a highly creative and motivated scientist to perform cutting-edge computational research on multimodal data from patients receiving engineered T cell immunotherapies.
We have recently completed groundbreaking clinical studies of CD19/CD22-targeted and GD2-targeted CAR T cell therapies (Spiegel et al. Nat Med 2021, Majzner et al. Nature 2022, Frank et al. Lancet 2024). We have generated a wealth of single-cell sequencing, spatial, clinical, and other types of data from these and other patients and established pipelines for data pre-processing, analysis, and integration (Good et al. Nat Med 2022; In Preparation). We now seek to build generative artificial intelligence (AI) models to nominate cell designs that will enable engineering the next generation of CAR T cell immunotherapies.
Applicants will have the opportunity to work with a stellar team of interdisciplinary scientists. This position will be located in the Center's Cancer Cell Therapy Data Hub, which is led by Dr. Zinaida Good and provides a collaborative environment that pushes the cutting edge of technology to learn from patients about why engineered cellular immunotherapies succeed or fail in patients. A successful candidate will leverage the hub’s multimodal data assets and model prototypes to build state-of-the-art generative AI models for in silico CAR T cell designs with the goal of improving therapeutic potential. We are located amid a vibrant academic research community at Stanford School of Medicine in the center of Silicon Valley.
The position is available immediately and the start date is flexible. The position is initially for one year with possibility of renewal based on performance.
- PhD or MD/PhD
- Strong programming skills, preferably in R and/or Python
- Previous expertise and/or interest in single-cell sequencing technologies, bioinformatics, spatial analyses, and generative AI is desired
- We are particularly interested in candidates who are self-motivated, think creatively, scientifically rigorous, and enjoy collaboration
- Cover letter indicating: (1) how your prior experience aligns with this position; and (2) how this position will further your career goals
- CV with complete list of publications
- Contact information for 3 references