Important Info
Applicants should submit their application to bschuele@stanford.edu
Join Our Diverse and Interdisciplinary Team as a Postdoctoral Scholar!
We are excited to invite you to become a part of our research team! We are seeking a highly motivated Postdoctoral Scholar to contribute to a cutting-edge research project focused on brain resilience using human iPSC models and multi-omics approaches. This collaborative project will be conducted within the Departments of Pathology and Neurology & Neurological Sciences.
About the Project:
Brain resilience refers to the capacity to resist adverse outcomes despite significant risk factors. In late-onset Alzheimer’s disease (AD), Apolipoprotein E4 (APOE4) is recognized as the most significant genetic risk factor. Individuals carrying one copy of APOE4 have approximately a 4-fold increased risk of developing AD, while those with two copies face a 15-fold increased risk compared to carriers of the ApoE3 allele. Despite this, a subset of APOE4 carriers exhibits resilience, maintaining cognitive function despite the presence of disease pathology.
This research project aims to develop human iPSC-derived central nervous system (CNS) cell types from APOE4 donors associated with both risk and resilience. We will perform comprehensive multi-omic and functional profiling of these cell cultures to uncover the biological mechanisms underlying resilience in APOE4 carriers.
EDUCATION AND EXPERIENCE:
● PhD in neuroscience, life sciences
KNOWLEDGE, SKILLS, AND ABILITIES:
● Extensive tissue culture laboratory experience (at least 1 year) is required. Good laboratory practices and sterile culture techniques are critical.
● Ability to undertake and complete large research projects and communicate findings to the field as demonstrated by first author publications in respected journals and oral conference presentations.
● Experience culturing and maintaining human iPSCs.
● Experience with neuronal and/or microglia differentiation using iPSCs.
● Experience culturing and assaying neuronal cultures (human iPSC-derived neurons).
● Experience with immunocytochemistry, confocal microscopy, and image analysis is strongly preferred. Experience with molecular biology and biochemistry techniques such as DNA/RNA extraction, PCR, cloning, protein extraction, and Western blot.
● Experience omics data analysis.
●General understanding of scientific principles. Demonstrated performance to use knowledge and skills when needed.
● Demonstrated ability to apply theoretical knowledge of science principals to problem solve work.
● Ability to maintain detailed records of experiments and outcomes.
● Ability to quickly learn and master computer programs, databases, and scientific applications.
● Excellent organizational skills and demonstrated ability to accurately complete detailed work.
In addition, preferred requirements include:
● Strong analytical skills and excellent judgment.
● Ability to work under deadlines with general guidance is essential.
● The candidate should be able to work independently, be highly motivated, collaborative, well organized, adaptable and work well within an interdisciplinary and international team.
● Good communication and interpersonal skills are essential
WORKING CONDITIONS:
● May require working in close proximity to blood borne pathogens.
● May require work in an environment where animals are used for teaching and research.
● Position may at times require the employee to work with or be in areas where hazardous materials and/or infectious diseases are present.
● Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator.
● May require extended or unusual work hours based on research requirements and business needs.
- CV
- letter outlining interest and motivations
- names and contact information of two references