In our laboratory, we are at the forefront of cutting-edge research focused on the integration of cryogenic electron microscopy and tomography with state-of-the-art artificial intelligence-driven image analysis techniques. Our primary objective is to uncover distinctive and common cellular structural patterns associated with various human diseases. With access to mulitple state-of-the-art electron cryomicroscopes and cutting-edge detectors, our laboratory is well-equipped to advance the field. Our methodological innovations are motivated by the imperative to gain deeper insights into disease pathologies and to pinpoint potential therapeutic targets within cells.
We are active engaging extensive collaborations with biomedical researchers spanning diverse domains including neurodegeneration, visual impairments, viral infections, cancer and cardiovascular disorders. This collaborative approach enables us to look for possible subcellular structure patterns common to these diseases, tackle complex disease-related questions from multiple angles, enriching our understanding of these conditions and opening new avenues for potential interventions.