The Kay lab is interested in Gene Transfer, Genome Editing and Non-coding RNA biology. The current research is studying: 1) rAAV vectors specifically: developing capsid libraries, chemical modification of vectors and screening approaches that will provide improved vectors for human application; molecular mechanism of discordance in vector transduction between species; molecular mechanisms involved in AAV transduction; and chromatin formation of gene transfer vector genomes in primary tissues. 2) Approaches to achieve therapeutic levels of non-nuclease mediated genome editing using rAAV vectors. 3) Non coding RNAs: association between long-non coding RNAs and miRNA biogenesis in whole tissues; tRNA derived small RNAs and their role in regulating ribosome biogenesis in cancer; and role of Line1 structural RNAs in controlling gene expression.
Professor
Stanford Departments and Centers:
Pediatrics
T32 affiliation:
Institutional Training Grant in Genome Science
Research Interests: