Gavin Sherlock

The Sherlock lab uses experimental approaches to understand the evolutionary process, specifically interested in i) the beneficial mutation rate, ii) the distribution of fitness effects (DFE) of beneficial mutations, iii) the identities of beneficial mutations (are they gain or loss of function, are they recessive, dominant or overdominant, are the genic or regulatory?) and iv) how do each of these change as a function of genotype, ploidy and environment. We are also interested in how mutations that are beneficial in one environment fare in others (pleiotropy), and we are interested in exploring at what level experimental evolution can be deterministic, and at what level it is stochastic. We typically use serial batch culture experiments in conjunction with lineage tracking and high throughput sequencing to understand the adaptive changes that occur in yeast in response to selective pressures as they evolve in vitro.

Department URL:
https://med.stanford.edu/genetics.html