My lab is an interdisciplinary group spanning medical physics and technology development, basic cancer and radiation biology, and preclinical and clinical imaging.
The two main programs are:
1. Development of next-generation medical linear accelerator technology for delivery of ultra-rapid FLASH radiation therapy for cancer, working closely with collaborators at SLAC National Accelerator Laboratory. We are currently designing and building a system for preclinical FLASH research in small animal models. Using the same platform technologies, we are also laying the groundwork for a clinical treatment system (PHASER) for FLASH radiation therapy for general cancer therapy in human patients, with a focus on compact, economical, and clinically efficient design.
2. Fundamental radiation biology research in ultra-rapid FLASH radiation therapy in small animal and in vitro models. We are investigating the biological mechanisms underlying the observed therapeutic index of FLASH, producing less normal tissue radiation injury and simultaneously equal or increased tumor killing compared to conventional dose rate irradiation. We are investigating physical, radiochemical, immunological, vascular, and other microenvironmental aspects in multiple model systems.