PRISM supports all faculty in recruiting postdocs. The faculty listed on this page have expressed special interest in the PRISM program and most are actively recruiting. As you look for potential postdoc mentors, consider how faculty research interests align with your own.
For an overview of how the Faculty Nomination/Selection process works, please view our Stanford PRISM Faculty Guide.
As a rule of thumb, we recommend starting with the faculty listed on this page and then expanding your search to other faculty across the university. This is not intended to be a comprehensive list of all faculty eligible to appoint postdocs through PRISM.
For School of Medicine faculty, browse SoM Departments or find details about individual faculty members in the School of Medicine via Community Academic Profiles (CAP).
For faculty outside of the School of Medicine, browse departments in the Natural Sciences, Earth Sciences, or Engineering and find details about individual faculty members in these areas via Stanford Profiles.
Please check back often -- Faculty/Lab profiles may be added or edited throughout the application period.
PRISM mentor | Research Interests |
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Utkan Demirci
Last Updated: June 24, 2022 |
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Maya Kasowski
Last Updated: June 23, 2022 |
I am a clinical pathologist and assistant professor in the Departments of Medicine, Pathology, and Genetics (by courtesy) at Stanford. I completed my MD-PhD training at Yale University and my residency training and a post-doctoral fellowship in the Department of Genetics at Stanford University. My experiences as a clinical pathologist and genome scientist have made me passionate about applying cutting-edge technologies to primary patient specimens in order to characterize disease pathologies at the molecular level. The core focus of my lab is to study the mechanisms by which genetic variants influence the risk of disease through effects on intermediate molecular phenotypes. |
Maya Mathur
Last Updated: February 02, 2023 |
Maya Mathur is an Assistant Professor at the Stanford University Quantitative Sciences Unit and the Associate Director of the Stanford Center for Open and Reproducible Science. She is a statistician whose methodological research focuses on advancing methods for meta-analysis, replication studies, and sensitivity analysis. She has received early-career and young investigator awards from the Society for Epidemiologic Research, the Society for Research Synthesis Methods, and American Statistical Association. |
Nima Aghaee Pour Anesthes, Periop & Pain Med
Last Updated: August 11, 2020 |
We are a machine learning lab with a primary focus on predictive modeling of clinical outcomes using multiomics biological assays. Our research covers a wide range of unconventional yet high-impact topics ranging from space medicine to the integration of mental health, physical health, immune fitness, and nutrition in various clinical settings. We are primarily a computational immunology research group but depending on the problem at hand, our datasets include clinical measurements, readouts from advanced wearable technologies, and various genomics and proteomics assays. |
Eric Gross Anesthes, Periop & Pain Med
Last Updated: August 11, 2020 |
Our laboratory is developing tools to study genetic variants commonly found in Asians within the basic science laboratory including CRISPR mouse models, drug development/design, and protein chemistry. Most of our laboratory uses basic science techniques to study the cardiovascular system and we are funded through the NIH from NIGMS and NHLBI. Our NIGMS funded project focuses on genetic variants in Asians and developing precision medicine strategies for reducing perioperative organ injury and precision medicine strategies for delivering anesthesia and pain relievers such as opioids. Our NHLBI funded project is to study the cardiopulmonary effects of e-cigarettes in rodents and to further determine how a common genetic variant in East Asians may impact the cellular toxicity of e-cigarettes.
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Sean Mackey Anesthes, Periop & Pain Med
Last Updated: August 06, 2020 |
Mission of our group is to “Predict, prevent and alleviate pain”. Broad range of human pain research topics including neuroimaging, transcranial magnetic stimulation, EEG, psychophysics, patient outcomes, learning healthcare systems across many NIH funded projects. Projects include mechanistic characterization of pain to novel treatment developments.
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Vivianne Tawfik Anesthes, Periop & Pain Med
Last Updated: July 13, 2022 |
Chronic pain affects 1 in 3 Americans at a huge cost to society. A more thorough understanding of the basic mechanisms contributing to chronic pain is crucial to the development of therapies that target the likely unique underlying causes of diverse pain conditions. Projects in the Tawfik Lab use clinically-informed basic science approaches to further understand the crosstalk between the nervous system and the immune system in several mouse models of perioperative injury. In particular, we have an interest in CNS glial cells (astrocytes and microglia) which, after injury, can contribute to central sensitization and persistence of pain. Preclinical use of glial modulators has been successful at reversing existing pain, however, translational efforts have thus far failed. We strive to further understand glial subtypes and functional phenotypes in order to better tailor glial-directed therapies. Our projects involve collaborations with several other labs in Neurology, Radiology and Anesthesiology in a collegial environment focused on rigorous science and close mentorship. |
Rhiju Das Biochemistry
Last Updated: August 11, 2020 |
We develop algorithms to predict and design the structures and energetics of RNAs and RNA/protein complexes. We test these ideas through community-wide blind trials; by enhancing NMR, crystallographic, and cryoelectron microscopy methods; and by designing new complexes. Upcoming projects involve directly visualizing how natural RNA machines work inside human cells and designing molecules that might enable RNA-based optogenetics, self-replication, and sequence-controlled synthesis of novel polymers. |
Dan Herschlag Biochemistry
Last Updated: September 02, 2020 |
To understand biology, we need chemistry and physics as the physical and chemical properties of biomolecules enable and constrain what biology can do and how it has evolved. We are particularly interested in questions of: (i) how enzymes work; (ii) how RNA folds; (iii) how proteins recognize RNA; (iv) RNA/protein interactions in regulation and control; and (v) the evolution of molecules and molecular interactions. Our interdisciplinary approaches span and integrate physics, chemistry and biology, employ a wide range of techniques, and are question driven. We have new projects in each of the above areas as we: |
Suzanne Pfeffer Biochemistry
Last Updated: August 28, 2020 |
Activating mutations in the LRRK2 kinase cause Parkinson's disease, and the major substrates of LRRK2 kinase are a subset of proteins called Rab GTPases. Together with our collaborators, we have discovered that phosphorylation of Rab proteins completely changes the partner proteins with which they interact and leads to a blockade in the formation of critical signaling structures called primary cilia. We are using biochemical, cell biological and genome-wide approaches to study the molecular cell biology of Parkinson's Disease by focusing on the consequences of Rab GTPase phosphorylation. We are also studying cholesterol transport out of lysosomes and lysosome dysfunction in neurodegenerative disease. |
Rajat Rohatgi Biochemistry, Med: Oncology
Last Updated: July 14, 2022 |
Our lab uses cellular, biochemical, and genetic approaches to understand the mechanism by which developmental signaling pathways, such as the WNT and Hedgehog pathways, function and how they are damaged in disease states. We use a broad range of approaches in our work: genome-wide CRISPR screens, proteomics, imaging, and both protein and lipid biochemistry. |
Rajat Rohatgi Biochemistry, Med: Oncology
Last Updated: January 12, 2022 |
The overall goal of our laboratory is to uncover new regulatory mechanisms in signaling systems, to understand how these mechanisms are damaged in disease states and how to devise new new strategies to repair their function. Specific areas are highlighted below: 1. The Hedgehog and WNT pathways, two cell-cell communication systems that regulate the formation of most tissues during development. These same pathways play central roles in tissue stem-cell function and organ regeneration in adults. Defects in these systems are associated with degenerative conditions and cancer. 2. Signal transduction at the primary cilium and the mechanism of cilia-associated human diseases. Primary cilia are solitary hair-like projections found on most cells in our bodies that function as critical hubs for signal transduction pathways (such as Hedgehog). Over fifty human genetic diseases, called “ciliopathies,” are caused by defects in cilia. Patients with ciliopathies can show phenotypes in nearly all organ systems, suffering from abnormalities ranging from birth defects to obesity. 3. Regulation of signaling pathways by endogenous lipids. The landscape of endogenous small-molecules and their biological functions remains a terra incognita, one that provides many opportunities to discover new regulatory layers in signaling pathways and other membrane dependent processes. 4. Biomolecular condensates in cancer and cancer therapeutics. The formation of reversible, membrane-less compartments in cells by the segregation of proteins into liquid phases, hydrogels or amyloid-like assemblies is an emerging principle of cellular organization. Emerging evidence shows that some cytotoxic drugs used in oncology can accumulate in and disrupt the biophysical properties of these condensates. A future challenge is to develop strategies to target such membraneless compartments (such as the nucleolus) for effective and safe cancer therapies. 5. Cellular adaptation to extreme tissue environments. Many cells in our bodies can be considered “extremophiles,” charged with maintaining homeostasis in the face of an environment containing markedly non-physiological concentrations of ions, small molecules and toxins. For instance, cells in the kidney medulla face tissue concentrations of ions, urea and other small molecules that are several-fold higher than blood. |
Rajat Rohatgi Biochemistry, Med: Oncology
Last Updated: July 14, 2022 |
A central focus of our laboratory is to uncover new regulatory mechanisms in cell-cell communication system, understand how these mechanisms are damaged in disease states and devise strategies to repair their function. We are actively recruiting post-doctoral fellows to join projects in the following areas:
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Julia Salzman Biochemistry, Biomedical Data Sciences
Last Updated: July 13, 2022 |
Statistical algorithms for genomics, RNA biology, splicing, cancer genomics, spatial transcriptomics |
Aaron Straight Biochemistry
Last Updated: July 13, 2022 |
Our laboratory studies the dynamics and organization of eukaryotic genomes. Every eukaryotic cell must compact its DNA into the nucleus while maintaining the accessibility of the DNA to the replication, repair, expression and segregation machinery. Eukaryotes accomplish this feat by assembling their genomes into chromatin and folding that chromatin into functional compartments. We are studying four key processes in the eukaryotic nucleus: 1) the genetic and epigenetic basis for centromere formation that enables chromosome segregation, 2) the role of noncoding RNAs in structuring the genome and regulating gene expression, 3) the formation of silent heterochromatin and its role in genome organization and 4) the activation of the embryonic genome at the maternal to zygotic transition. We rely on biochemistry, quantitative microscopy and genomics to probe genome dynamics in vitro and in living systems. Our goal is to uncover the core principles that organize eukaryotic genomes and to understand how genome organization controls organismal function. |
Ellen Yeh Biochemistry, Pathology, Microbiology and Immunology
Last Updated: July 14, 2022 |
The Yeh Lab studies the apicoplast, a unique plastid organelle in Plasmodium falciparum parasites that cause malaria. We are particularly focused on unbiased chemical and genetic screens to discover new cell biology and therapeutic targets for this important global health disease. Our work highlights the untapped opportunities in exploring divergent biology in non-model organisms, a theme we plan to expand in the lab by studying ocean algae (malaria's cousins!) and their role in the global ecosystem.
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Michael Fischbach Bioengineering
Last Updated: July 13, 2022 |
Small molecules from the human microbiota. Many of the most widely used human medicines come from soil and marine bacteria, including treatments for cancer, infectious disease, diabetes, and organ transplant. We have recently found that bacteria from a surprisingly underexplored niche -- the human body -- are prolific producers of drug-like small molecules. We are identifying small molecules from gut- and skin-associated bacteria, studying their biosynthetic genes, and characterizing the roles they play in human biology and disease. |
Polly Fordyce Bioengineering, Genetics
Last Updated: November 11, 2021 |
The central focus of our laboratory is to develop novel microfluidic technologies that for high-throughput and quantitative biophysics, biochemistry, and single-cell biology.
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Sarah Heilshorn Materials Sci & Engineering, Bioengineering, Chemical Engineering
Last Updated: December 01, 2021 |
Heilshorn's interests include biomaterials in regenerative medicine, engineered proteins with novel assembly properties, microfluidics and photolithography of proteins, and synthesis of materials to influence stem cell differentiation. Current projects include tissue engineering for spinal cord and blood vessel regeneration, designing injectable materials for use in stem cell therapies, and the design of biomaterials for culture of patient-derived biopsies and organoids. Postdoctoral candidates with expertise (or an interest in learning) preclinical animal models of injury and disease are particularly encouraged.
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Rogelio Hernandez-Lopez Genetics, Bioengineering
Last Updated: July 08, 2022 |
The Hernandez-Lopez Lab works at the interface of mechanistic, synthetic, and systems biology to understand and program cellular recognition, communication, and organization. We are currently interested in engineering biomedical relevant cellular behaviors for cancer immunotherapy. We are also launching new multidisciplinary projects. We are looking for outstanding, motivated graduate students and physician-scientists from diverse fields who are interested in joining our interdisciplinary research program. Postdoctoral candidates with expertise (or an interest in learning) preclinical animal models of disease or structural biology (cryo-EM) are particularly encouraged.
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Craig Levin Radiology, Physics, Electrical Engineering, Bioengineering, Radiology-MIPS, Stanford Cancer Center, Cardiovascular Med Institute, Neuroscience Institute
Last Updated: March 16, 2022 |
The research interests of the molecular imaging instrumentation lab are to create novel instrumentation and software algorithms for in vivo imaging of molecular signatures of disease in humans and small laboratory animals. These new cameras efficiently image radiation emissions in the form of positrons, annihilation photons, gamma rays, and/or light emitted from molecular contrast agents that were introduced into the body and distributed in the subject tissues. These contrast agents are designed to target molecular pathways of disease biology and enable imaging of these biological signatures in tissues residing deep within the body using measurements made from outside the body. The goals of the instrumentation projects are to advance the sensitivity and spatial, spectral, and/or temporal resolutions, and to create new camera geometries for special biomedical applications. The computational modeling and algorithm goals are to understand the physical system comprising the subject tissues, radiation transport, and imaging system, and to provide the best available image quality and quantitative accuracy. The work involves designing and building instrumentation, including arrays of position sensitive sensors, readout electronics, and data acquisition electronics, signal processing research, including creation of computer models, and image reconstruction, image processing, and data/image analysis algorithms, and incorporating these innovations into practical imaging devices. The ultimate goal is to introduce these new imaging tools into studies of molecular mechanisms and treatments of disease within living subjects.
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Alison Marsden Pediatrics, Bioengineering, Mechanical Engineering, Institute for Computational and Mathematical Engineering, Cardiovascular Med Institute
Last Updated: August 09, 2020 |
The Cardiovascular Biomechanics Computation Lab develops fundamental computational methods for the study of cardiovascular disease progression, surgical methods, treatment planning and medical devices. We focus on patient-specific modeling in pediatric and congenital heart disease, as well as adult cardiovascular disease. Our lab bridges engineering and medicine through the departments of Pediatrics, Bioengineering, and the Institute for Computational and Mathematical Engineering. We develop the SimVascular open source project.
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Lei Stanley Qi Bioengineering
Last Updated: January 27, 2023 |
We work on technology development for genome engineering, discovery-focused synthetic biology, and epigenetic gene therapy. We aim to develop new technologies for studying the mammalian genome and treating complex diseases. For technology development, we are interested in novel technologies that reprogram the mammalian genome and epigenome. We developed the first nuclease-dead dCas9 from the natural CRISPR-Cas9 nuclease. We developed a series of CRISPR tools that greatly enriched the CRISPR toolbox and expanded genome engineering beyond editing. These tools include CRISPR interference (CRISPRi) and CRISPR activation (CRISPRa) for targeted gene activation and repression, LiveFISH for live imaging of DNA and RNA, CRISPR-GO for manipulating the 3D genome organization, and miniature Cas (CasMINI) and hyper-efficient Cas12a (hyperCas12a) for in vivo applications. We harness natural molecules for molecular engineering and evolve novel functions. These tools are broadly used by the community for research and and translational applications. For discovery-focused synthetic biology, we apply synthetic biology to design and engineer molecules and molecular circuits in mammalian cells. We use synthetic systems to study how cells can be rationally designed as an 'engineering' entity and be harnesses for disease treatment. For example, we engineer T cells to detect new antigens to kill cancer cells or stem cells to integrate environment cues to determine cell fate. By engineering at the scale from molecular to cellular to organismal level, we hope to make synthetic biology a better discovery tool. For epigenetic gene therapy, we combine epigenome engineering, synthetic biology, and disease models to develop novel therapy to treat cancer, neurodegeneration, and complex genetic diseases. We aim to reveal the importance of noncoding elements including enhancers in the regulation of genome and disease. We harness safe and powerful tools to precisely rewrite the epigenome marks to reverse or cure diseases. We developed PAC-MAN as a treatment to influenza and broad variants of SARS-CoV-2. We aim to greatly expand genome and epigenome engineering towards neurodegenerative diseases and complex diseases. |
Mark Skylar-Scott Bioengineering
Last Updated: March 03, 2021 |
The Skylar-Scott Lab specializes in cardiovascular tissue biomanufacturing, seeking to push the complexity and scale at which tissue can be designed and manufactured on demand. By integrating high-throughput culture of designer organoids with new machines and methods for advanced 3D bioprinting, our laboratory seeks to enhance the maturation and function of vascularized cardiac tissues in vitro and in vivo. Our lab is embedded at the intersection of synthetic biology, tissue engineering, and 3D printing. We are always seeking new students and postdocs with a demonstrated passion for rethinking how we make things, with relevant expertise in bioengineering, mechanical engineering, or materials science. |
Bo Wang Bioengineering
Last Updated: July 14, 2022 |
Flatworms include more than 44,000 parasites, many of which are pathogenic to humans or livestock, with flukes, tapeworms, and hookworms as notorious representative species. They typically transmit through multiple hosts using several drastically different body plans specialized for infecting and reproducing within each host. Although flatworms’ complex life cycles were established over a century ago, little is known about the cells and genes they use to optimize their transmission potential, thereby limiting our ability to develop effective therapeutic and preventive strategies. We aim to develop a comprehensive cellular and molecular understanding of the stereotypical life cycle of a blood fluke, Schistosoma mansoni, and identify novel targets to block it. Schistosomes cause one of the most prevalent but neglected infectious diseases, schistosomiasis. With over 250 million people infected and a further 800 million at risk of infection, schistosomiasis imposes a global socioeconomic burden comparable to that of tuberculosis, HIV/AIDS, and malaria. This project will use novel single-cell technologies to build a schistosome "cell atlas", and map the developmental states of their stem cells as they produce all other cell types in the schistosome body plans. |
Bo Wang Bioengineering
Last Updated: January 26, 2022 |
We integrate single-cell multiomics, advanced microscopy, and quantitative models to understand organismal regeneration using a variety of organisms. We invite postdoctoral colleagues to build on our current systems or establish new models to understand foundamental principles controlling regeneration.
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Peter Yang Orthopedic Surgery, Materials Sci & Engineering, Bioengineering
Last Updated: July 13, 2022 |
Biomaterials, medical devices, drug delivery, stem cells and 3D bioprinting for musculoskeletal tissue engineering |
Christopher Barnes Biology, Structural Biology
Last Updated: July 22, 2022 |
We combine biophysical methods with in vivo approaches to understand how viruses such as HIV and SARS-CoV-2 infect host cells and elicit specific humoral immune responses. Our research will translate knowledge of the structural correlates of antibody-mediated neutralization of viruses into the rational development of highly protective antibodies. A related goal is the structure-based design of potent and stable immunogens for vaccination. |
Dominique Bergmann Biology
Last Updated: July 14, 2022 |
Our lab is interested in how stem cell-like populations are created and maintained in developing, environmental responsive tissues. We primarily use the Arabidopsis stomatal lineage for these studies because this epidermal cell lineage distills features common to all tissue development: stomatal precursor cells are chosen from an initially equivalent field, they undergo asymmetric and self-renewing divisions, they communicate among themselves to establish pattern and they terminally differentiate into stable, physiologically important cell-types. In the past decade, we have developed the stomatal lineage into a conceptual and technical framework for the study of cell fate, stem-cell self-renewal and cell polarity. Currently, we are especially interested in: (1) using single-cell technologies to capture transcriptomic and chromatin state information about cells as they transit through various identities (stem cell-like, committed, differentiated, and reprogrammed); (2) using new ‘in vivo biochemical’ approaches to identify transcription factor modules in the nuclear and cell polarity complexes at the plasma membrane, and to determine how these complexes guide changes in cell shape, size and fate; (3) computational modeling of pattern formation in the epidermis, and (4) testing how environmental information impacts developmental choices and robustness. |
Dominique Bergmann Biology
Last Updated: July 13, 2022 |
The overall goal of my research program is to understand how stem cell-like populations are created and maintained in the context of an intact and environmental responsive tissue. We use the Arabidopsis stomatal lineage for these studies as this epidermal cell lineage distills many of the features common to all tissue development: stomatal precursor cells are chosen from an initially equivalent field, they undergo asymmetric and self-renewing divisions, they communicate among themselves to establish pattern and they terminally differentiate into stable, physiologically important cell-types. In the past decade, we have developed the stomatal lineage into a conceptual and technical framework for the study of cell fate, stem-cell self-renewal and cell polarity. Currently, we are especially interested in: (1) using new single-cell technologies to capture transcriptomic and chromatin state information about cells as they transit through various identities (stem cell-like, committed, differentiated, and reprogrammed); (2) using new ‘in vivo biochemical’ approaches to identify plant-specific cell polarity complexes and how these guide changes in cell shape, size and fate; (3) computational modeling of pattern formation in the epidermis, and (4) testing how environmental information impacts developmental choices and robustness. |
Xiaoke Chen Biology
Last Updated: January 12, 2022 |
Our lab study neural circuits underlying motivated behaviors and how maladaptive change in these circuits causing neuropsychiatric disorders. We currently focuse on pain and addiction. Both conditions trigger highly motivated behaviors, and the transition to chronic pain and to compulsive drug use involves maladaptive changes of the underlying neuronal circuitry. Neuroal circuits mediating opioid addiction: We established the paraventricular nucleus of the thalamus (PVT) to nucleus accumbens (NAc) pathway as a promising target for treating opioid addiction (Zhu et al., 2016), and revealed the PVT’s role in tracking the dynamics of behavioral relevance and gating associative learning (Zhu et al., 2018). Using brainwide activity mapping, we identifed a distributed neuronetwork including 23 brain regions that might involve in storing drug-associated memory (Keyes et al, 2020). Ongoing work in the lab is to examining how Neuroal circuits underlying descending pain modulation: We developed a battery of viral, genetic and imaging tools and gained robust access of the mu-opioid receptor expressing spinal cord projecting neurons in the rostromiddel medulla (RVM). We found that these neurons has limited contirbution to nociception in normal mice but is essential for the initiation and maintenance of nerve injury induced chronic pain. We are profiling nerve injury caused gene expression changes in these neurons with the goal to identify key molecular plays that engages these neurons in chronic pain. Based on our finding, we will develop gene therapy reagents and small molecues to treat chronic pain.
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Jonas Cremer Biology
Last Updated: June 23, 2022 |
We are a highly interdisciplinary research team, joined in our desire to derive a more mechanistic understanding of prokaryotic life. To elucidate how bacterial cells accumulate biomass and grow, we study the model organism Escherichia coli. Our approaches tightly combine quantitative experimentation with mathematical modeling to consider the coordination of major physiological processes across scales; from metabolism and protein synthesis, via cell-size control, to swimming. We further focus on gut bacteria and their interactions with each other and the human host. Our analyses include considerations of intestinal physiology and diet habits on the host side, as well as metabolism, growth-physiology, ecology, and evolution on the bacterial side. |
Martha Cyert Biology
Last Updated: January 26, 2022 |
We discover and elucidate new Ca2+-regulated signaling pathways in humans by studying calcineurin, the conserved Ca2+/calmodulin-regulated protein phosphatase. The calcineurin phosphatase dephosphorylates proteins only when Ca2+ signaling is triggered, for example by a hormone, growth factor, neurotransmitter etc. Previous work from the Cyert lab showed how calcineurin allows yeast cells to survive environmental stress (Goldman et al, 2014, Molecular Cell). Currently, we are studying human calcineurin which is ubiquitously expressed and plays critical roles throughout the body, but especially in the nervous, cardiac and immune systems. Calcineurin is best known for activating the adaptive immune response by dephosphorylating the NFAT transcription factors, and is the target of widely prescribed immunosuppressant drugs, FK506 (tacrolimus) and Cyclosporin A. However, these drugs cause many adverse effects due to inhibition of calcineurin in non-immune tissues, where the majority of calcineurin substrates and functions remain to be discovered. We are using a variety of experimental and computational strategies to systematically map human calcineurin signaling pathways in healthy and diseased cells. These rely on identifying Short Linear peptide Motif (SLiMs), i.e. highly variable sequences that reside in regions of intrinsic disorder and mediate specific interactions of substrates and regulators with calcineurin. These approaches have revealed surprising roles for calcineurin that we are currently studying: in Notch signaling, trafficking though nuclear pores, at centrosomes/cilia, and in regulating phosphoinositide signaling at membranes. A new project is studying calcineurin's role in pancreatitis, where we are identifying calcineurin substrates that mediate the major pathophysiological events that occur during pancreatitis. We are also interested in understanding how reversible protein lipidation (palmitoylation) is regulated and how palmitoylation impacts calcineurin signaling at membranes by modifying calcineurin itself and some of its regulators. To learn more about our studies, see our recent papers: Wigington, Roy et al, 2020, Molecular Cell (https://pubmed.ncbi.nlm.nih.gov/32645368/) and Ulengin-Talkish et al, Nature Communications (https://www.nature.com/articles/s41467-021-26326-4).
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Martha Cyert Biology
Last Updated: July 13, 2022 |
By studying calcineurin, the conserved Ca2+/calmodulin-regulated protein phosphatase, we aim to discover and elucidate new Ca2+-regulated signaling pathways in humans. The calcineurin phosphatase dephosphorylates proteins only when Ca2+ signaling is triggered, for example by a hormone, growth factor, neurotransmitter etc. Previous work from the Cyert lab discovered how calcineurin allows yeast cells to survive environmental stress (Goldman et al, 2014, Molecular Cell). Currently, we are studying human calcineurin which is ubiquitously expressed and plays critical roles throughout the body, but especially in the nervous, cardiac and immune systems. Calcineurin is best known for activating the adaptive immune response by dephosphorylating the NFAT transcription factors, and is the target of widely prescribed immunosuppressant drugs, FK506 (tacrolimus) and Cyclosporin A. However, these drugs cause many adverse effects due to inhibition of calcineurin in non-immune tissues, where the majority of calcineurin substrates and functions remain to be discovered. We are using a variety of experimental and computational strategies to systematically map human calcineurin signaling pathways in healthy and diseased cells. We have uncovered surprising roles for calcineurin in Notch signaling, regulation of transport though nuclear pores, and at centrosomes. See our recent paper (Wigington, Roy et al, 2020, Molecular Cell) to learn more about our studies. |
José Dinneny Biology
Last Updated: December 01, 2021 |
In the next 50 years, one of the greatest advances we can make for global human health is the realization of a society that is fully sustainable. My research aims to improve agricultural sustainability by using a holistic approach that integrates across genetic, cellular and organismal scales to understand how plants survive stressful environments (Dinneny, 2015a; 2019). Prior research has explored water-stress responses at unparalleled spatial and temporal resolution, and identified the endodermal tissue layer as a critical signaling center for controlling growth and tissue differentiation in roots (Duan et al., 2013; Geng et al., 2013; Dinneny et al., 2008). The discovery of novel adaptive mechanisms used by roots to capture water established potential targets for breeding to improve water use efficiency (Bao et al., 2014; Sebastian et al., 2016). The invention of imaging methods enabled multidimensional studies of plant acclimation and illuminated our understanding of organ system growth from germination to senescence (Rellán-Álvarez et al., 2015; Sebastian et al., 2016). Physiological and molecular insight has been gained in understanding how plants sense water availability through computational modeling of tissue hydraulics (Robbins and Dinneny, 2015, 2018). Additionally, fine-scale biomechanical measurements identified a novel mechanism by which salinity damages cells through its effects on cell-wall integrity (Feng et al., 2018). I have paired my research with a personal passion for improving the education of young plant scientists, engaging lawmakers through science policy, and by being a vocal advocate for the broad deployment of agricultural biotechnology (Fahlgren et al., 2016, Friesner et al., 2021). |
Jessica Feldman Biology
Last Updated: November 11, 2021 |
Underlying the complexity of the human body is the ability of our cells to adopt diverse forms and functions. This process of cell differentiation requires cells to polarize, translating developmental information into cell-type specific arrangements of intracellular structures. The major goal of the research in my laboratory is to understand how cells build these functional intracellular patterns during development. In particular, we are currently focused on understanding the molecules and mechanisms that build microtubules at cell-type specific locations and the polarity cues that guide this patterning, both of which are essential for normal development and cell function. We study these processes in living animals because the chemical, mechanical, and ever-changing environments experienced by cells in intact organisms are not readily replicated ex vivo. Thus, we take innovative approaches in the model organism C. elegans using novel genetic and proteomic tools, high resolution live imaging, and embryological manipulations. |
Hunter Fraser Biology
Last Updated: January 27, 2023 |
We study the evolution of complex traits by developing new experimental and computational methods. Although genetics is often taught in terms of simple Mendelian traits, most traits are far more complex. They evolve via a multitude of genetic changes, each having a small effect by itself, which in sum give rise to the spectacular adaptation of every organism to its environment. Our work brings together quantitative genetics, genomics, epigenetics, and evolutionary biology to achieve a deeper understanding of how genetic variation shapes the phenotypic diversity of life. Our main focus is on the evolution of gene expression, since this is the primary fuel for natural selection. Our long-term goal is to understand the genetic basis of complex traits well enough to introduce them into new species via genome editing. |
Christine Jacobs-Wagner Biology
Last Updated: December 02, 2021 |
The Jacobs-Wagner lab has two main research interests:
Department URL:
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Ron Kopito Biology
Last Updated: December 01, 2021 |
The Kopito laboratory seeks a molecular understanding of how cells maintain the fidelity of their proteomes. Unlike DNA, which can be repaired if damaged or incorrectly made, proteins cannot be mended. Instead, damaged or incorrectly synthesized proteins must be rapidly and efficiently destroyed lest they form toxic aggregates. Our laboratory use state-of-the-art cell biological, genetic and systems-level approaches to understand how proteins are correctly synthesized, folded and assembled in the mammalian secretory pathway, how errors in this process are detected and how abnormal proteins are destroyed by the ubiquitin-proteasome system.
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Ron Kopito Biology
Last Updated: August 11, 2020 |
The Kopito laboratory seeks a molecular understanding of how cells maintain the fidelity of their proteomes. Unlike DNA, which can be repaired if damaged or incorrectly made, proteins cannot be mended. Instead, damaged or incorrectly synthesized proteins must be rapidly and efficiently destroyed lest they form toxic aggregates. Our laboratory use state-of-the-art cell biological, genetic and systems-level approaches to understand how proteins are correctly synthesized, folded and assembled in the mammalian secretory pathway, how errors in this process are detected and how abnormal proteins are destroyed by the ubiquitin-proteasome system.
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Ron Kopito Biology
Last Updated: July 27, 2021 |
The Kopito laboratory seeks a molecular understanding of how cells maintain the fidelity of their proteomes. Unlike DNA, which can be repaired if damaged or incorrectly made, proteins cannot be mended. Instead, damaged or incorrectly synthesized proteins must be rapidly and efficiently destroyed lest they form toxic aggregates. Our laboratory use state-of-the-art cell biological, genetic and systems-level approaches to understand how proteins are correctly synthesized, folded and assembled in the mammalian secretory pathway, how errors in this process are detected and how abnormal proteins are destroyed by the ubiquitin-proteasome system.
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Liqun Luo Biology
Last Updated: February 03, 2022 |
The human brain contains about 100 billion neurons, each making thousands of synaptic connections. While individual neurons can themselves perform sophisticated information processing, it is the assembly of neurons into circuits via specific patterns of synaptic connections that endows our brain with the computational capacity to sense, act, think, and remember. How are neurons organized into specialized circuits to perform specific functions? How are these circuits assembled during development? We are investigating these questions in the brains of the fruit fly (~100 thousand neurons) and mouse (~100 million neurons). We have developed molecular-genetic and viral tools, and are combining them with transcriptomic, proteomic, physiological, and behavioral approaches to study these problems.
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Erin Mordecai Biology, Woods Institute
Last Updated: January 12, 2022 |
Our research investigates how environmental changes like climate and land use change are affecting infectious diseases in humans and wildlife. We use tools from disease ecology, including mathematical and statistical models, health surveillance data, remotely sensed data, laboratory experiments, and field surveys to better understand the mechanisms by which changes in temperature and habitat affect vectors and disease transmission. |
Ashby Morrison Biology
Last Updated: July 13, 2022 |
The regulation of chromatin structure is essential for all eukaryotic organisms. Our research interests are to determine the contribution of chromatin to mechanisms that maintain genomic integrity and metabolic homeostasis in the context of disease and development. We utilize a varied experimental approach that includes computational, biochemical, molecular and cellular assays in both yeast and mammalian systems to ascertain the contribution of chromatin remodelers and histone modifiers to carcinogen susceptibility and metabolic gene expression. We hope to contribute to the formulation of epigenetic therapies that treat genomic and metabolic dysfunction, which influence cancer, heart disease, and diabetes to name a few.
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Lauren O'Connell Biology, Neuroscience Institute
Last Updated: August 10, 2020 |
We study how genetic and environmental factors contribute to biological diversity and adaptation. We are particularly interested in understanding (1) how behavior evolves through changes in brain function and (2) how animal physiology evolves through repurposing existing cellular components. |
Kabir Peay Biology
Last Updated: August 10, 2020 |
I study how ecological communities assemble and influence ecosystem processes, focusing on the role of microbial symbioses, which are ubiquitous in plants and animals. My research is driven primarily by intellectual curiosity about the unseen organisms that shape our planet, but is also aimed to provide knowledge that can be used to better manage ecosystem responses to global change, agriculture, and human health. |
Naima Sharaf Biology
Last Updated: August 25, 2021 |
Proteins embedded in the cell envelope of bacteria perform multiple important functions, including signaling, nutrient acquisition, and export of virulence factors. Understanding the structure and functions of these proteins is critical for the development of new anti-bacterial therapies. Currently, the lab focuses on both ABC transporters and lipoproteins of Gram-negative bacteria. The ultimate goal of the research to translate basic lipoprotein research into novel therapuetics. My goal as a mentor is to contribute to my mentees’ scientific and professional development by leveraging their strengths and providing them with the tools and resources they need to pursue their desired careers. My mentoring philosophy relies on (1) maintaining honest and open communication, (2) providing feedback and guidance, (3) setting clear expectations, and (4) creating a supportive and inclusive learning environment. |
Jan Skotheim Biology
Last Updated: August 10, 2020 |
My overarching goal is to understand how cell growth triggers cell division. Linking growth to division is important because it allows cells to maintain a specific size range to best perform their physiological functions. For example, red blood cells must be small enough to flow through small capillaries, whereas macrophages must be large enough to engulf pathogens. In addition to being important for normal cell and tissue physiology, the link between growth and division is misregulated in cancer. |
Alice Ting Biology, Genetics, Chemistry
Last Updated: January 12, 2022 |
We are a chemical biology laboratory focused on the development of technologies to map molecules, cells, and functional circuits. We apply the technologies to understand signaling in the mitochondria and in the mammalian brain. Our technologies probe molecules and functional networks at both the sub-cellular and multi-cellular level, leveraging our laboratory’s unique strengths in chemical synthesis, protein engineering, directed evolution, proteomics, and microscopy. While we strive to develop technologies that are broadly applicable across biology, we also pursue applications of our methods to neuroscience and mitochondrial biology in our own laboratory and through collaborations. Our research program is broadly divided into three areas: (1) molecular recorders for scalable, single-cell recording of past cellular events; (2) molecular editors for the precise manipulation of cellular biomolecules, pathways, and organelles; and (3) proximity labeling for unbiased discovery of functional molecules.
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Zhiyong Wang Biology
Last Updated: October 02, 2020 |
The goal of our research is to illucidate the signaling mechanisms that regulate plant growth and environmental responses. Plants have remarkable ability to alter growth and development in response to environmental signals. In fact, this ability is essential for their survival in nature as sessile organisms and is also a major target for breeding high-yield crops. My lab has dissected the signaling networks that integrate hormonal (brassinosteroid, auxin, gibberellin), environmental (light, temperature, pathogens), and nutritional (sugar) signals in regulating plant growth. We use a wide range of approaches including proteomic, genomic, and genetic approaches in Arabidopsis and algae. Our research has focused on the brassinosteroid (BR) signaling pathway, which is the best understood receptor kinase signaling pathway in plants. We have elucidated how this steroid signal is transduced from the receptor kinase BRI1 to the transcription factor BZR1, and how BR crosstalks with other growth hormones, light, temperature, pathogen, and sugar signals in optimizing shoot and root growth. Current focuses of our lab include: (1) How does nutrient signaling through O-linked glycosylation (O-GlcNAc and O-fucose modifications) regulate plant growth? (2) How does sugar-dependent O-glycosylation crosstalk with BR-dependent phosphorylation in regulating transcription, RNA splicing, and translation? (3) How do GSK3 kinase and BSU phosphatase regulate cell division and membrane trafficking? (4) How do receptor kinases maintain cell wall integrity during cell growth and under stress? |