email to Olivia Martinez : firstname.lastname@example.org
The Martinez laboratory laboratory investigates the immune response to viruses and allogeneic tissues. We are interested in characterizing the human immune response to EBV, CMV, and SARS-CoV-2 to distinguish features that are associated with control of the virus or result in pathologies including COVID-19, MIS-C, and post-transplant viral disease. Projects that are available include:
1) analysis of the diversity of TCR usage in the response to EBV, CMV, and SARS-CoV-2 through the use of next generation sequencing and single cell approaches to evaluate T cell phenotype and function;
2) characterization of the natural killer (NK) cell populations that participate in the response to viruses;
3) determining the role of the viral protein LMP1 in activation of the PI3K/Akt/mTOR pathway and the effect of targeting this pathway in EBV-associated B cell lymphoma development.
4) identification of novel host gene targets and pathways of oncogenesis utilized by EBV.
5) investigating the contribution of myeloid cells to rejection of composite tissue allografts and the use of nanoparticle delivery of immunosuppressive agents.
Studies are NIH-sponsored and will utilize cell lines as well as existing extensive repositories of human blood and tissue samples. Animal models of transplant immunology and tumor immunology are also established in the lab.
- We seek a candidate who is independent, self-motivated, organized, and with good oral and written communication skills.
- The successful candidate will have experience in high dimensional methodologies including mass cytometry (CyTOF), T cell receptor repertoire analysis, viral genomics or other related approaches to assess immune cell diversity and function.
- The candidate will be a recent PhD in a relevant field (immunology, virology, molecular biology or related) and prior first author publications.
- Experience in sterile tissue culture techniques, flow cytometry, and molecular biology techniques and prior experience in basic immunology, transplant immunology, or cancer immunology is a plus.
- A statement of research interests
- Letters of recommendaton may be requested