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Open Postdoctoral position, faculty mentor Kacper Rogala

Important Info

Faculty Sponsor (Last, First Name): 
Rogala, Kacper
Stanford Departments and Centers: 
Structural Biology
Chemical and Systems Biology
Postdoc Appointment Term: 
open-ended
Appointment Start Date: 
ASAP
How to Submit Application Materials: 

Please submit your application directly to Dr. Kacper Rogala at rogala@stanford.edu.

Postdoctoral positions are available in the Rogala Lab at Stanford University — https://rogala.stanford.edu.
 
Rogala Lab belongs in the Stanford’s Department of Structural Biology and the Department of Chemical & Systems Biology. The lab is an integral part of the Stanford Cancer Institute, and we are based in the brand new Biomedical Innovations Building on the main campus.
 
WHO ARE WE LOOKING FOR?
We are currently expanding our team, and have open positions for highly motivated post-doctoral candidates with a deep interest in deciphering protein mechanisms.
We are looking for two types of candidates:

  1. Cell biologists / biochemists, who will bring unique expertise to the lab and lead us towards new uncharted territories. We will train you in our structural and chemical biology approaches — to broaden your skill set and help you develop into a researcher able to tackle biological problems at many different scales.
  2. Structural biologists / biophysicists, who will take on the most challenging structural projects in the lab, and push the boundaries of what can be accomplished with cryo-EM and other structural and biophysical techniques.

In general, If you are a highly driven individual, who is thrilled by the prospect of discovering fundamental biological mechanisms and applying that knowledge in our shared quest to fight cancer, then this lab is for you. You will find like-minded colleagues here — we are hungry for discovery and we want to make an impact for patients. We set the compensation of our postdocs to the Stanford rates, and we strongly encourage the candidates to explore applying for extramural fellowships and grants to support their research.
 
WHY JOIN THE ROGALA LAB?
The advantage of joining a young lab like ours is that we have multiple near-complete projects that you will be responsible for driving to completion and publication — as the first author. In parallel to that, you will be given resources, support and mentorship to start new projects from scratch and become even better scientifically. Importantly, our lab is friendly to postdocs from all walks of life, and we cherish trust, inclusiveness and intellectual curiosity. Most importantly, your success is our success, and as such, our lab operates with a growth mindset for all of our trainees. We put a heavy emphasis on training and skills development — across a wide range of experimental and computational techniques. And through collaboration, strong work ethic, seeking feedback, and trying out new strategies, we drive innovation and novel discoveries for our team.
 
RESEARCH IN THE LAB
We are a team of structural and chemical biologists fascinated by how cells control their metabolism in response to nutrients. How are nutrients recognized by their protein sensors? How is their transport across cellular and intracellular membranes regulated? And, how is nutrient sensing integrated with other chemical signals, such as growth factors, to determine cellular decisions, especially the decision: to grow or not to grow? We are aiming to answer these fundamental questions at the level of ångstroms, nanometers, and micrometers — with cryo-EM, X-ray crystallography, and a full range of other techniques that span biology, chemistry, physics, and computation. Many proteins in nutrient signaling pathways are deregulated in cancer, and in parallel to the mechanistic structural work, we are also developing targeted chemical probes to modulate activity of these proteins in cells and organisms.

Our latest papers on this topic are:

  • Valenstein and Rogala et al. (2022) Structure of the nutrient-sensing hub GATOR2. Nature, 607(7919):610-616. PMID: 35831510 // Paywall-free article.
  • Rogala et al. (2019) Structural basis for the docking of mTORC1 on the lysosomal surface. Science, 366(6464):468-475. PMID: 31601708 [open-access].
  • Shen and Rogala et al. (2019) Cryo-EM structure of the human FLCN-FNIP2-Rag-Ragulator complex. Cell, 179(6):1319-1329.e8. PMID: 31704029 [open-access].
Required Qualifications: 

EDUCATION

  • PhD-level wet-lab scientists, with experience in managing an independent research project to completion and publication.
  • Background in cell biology / biochemistry / structural biology / biophysics — or related fields.

SKILLS AND ABILITIES

  • Ability to learn quickly and to work well both independently and as part of a team.
  • Ability to work effectively with a wide variety of people from all backgrounds.
  • Ability to train, mentor, and supervise research technicians, students, and other entry-level lab staff.
  • Very good communication skills in English.
  • High level of professionalism and developed interpersonal skills.
  • Positive attitude with a problem-solving mindset.
Required Application Materials: 

Potential candidates, please include the following items as part of your application (preferably as a merged PDF):

  • A cover letter including: (1) a summary of your previous research experience, (2) the reason why you decided to apply to our lab, (3) and the reason why we should consider you for this position (e.g.what expertise / ideas can you bring to our lab).
  • Your curriculum vitae.
  • Names and contact information to three reference writers.

 

Stanford is an equal opportunity employer and all qualified applicants will receive consideration without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, or any other characteristic protected by law.