To apply, please complete this application form and include all pertinent documents: https://app.smartsheet.com/b/form/c7da3b8be87f4e228a7b0b74dfac1674
Prof. Vinit Mahajan’s group in Department of Ophthalmology, Stanford School of Medicine is seeking applications for a postdoctoral fellow position from ambitious, enthusiastic, and recent Ph.D. holders or graduate students who are expecting to finish his/her graduate degree in structural biology, biophysics, biochemistry, bioengineering, molecular cell biology, or pharmaceutics. The successful candidate will be a structural biologist with strong interests in biomedical, translational, and pharmaceutical sciences, who can carry out one or few structural biology projects for eye disease proteins. Dr. Mahajan is a physician/surgeon, and a scientist, who is the vice chair for research and the director of Molecular Surgery Program of the Stanford’s Byers Eye Institute. He runs a large interdisciplinary group of scientists and clinicians, who are actively seeking for therapeutics and cure for eye patients (https://mahajanlab.stanford.edu/). Mahajan group is in a close collaboration with Prof. Soichi Wakatsuki, Structural Biology Department, Stanford School of Medicine and SLAC National Accelerator Laboratory (http://med.stanford.edu/wakatsukilab.html). Dr. Wakatsuki leads Biosciences Division of Stanford Synchrotron Radiation Lightsource (SSRL) Directorate at SLAC. Dr. Wakatsuki’s interests cover protein-protein interactions (Comerci et al. Nat. Comm. 2019; Herrmann et al. PNAS 2019), enzyme dynamics (Stoffel et al. PNAS 2019), and structure-based drug design (Hwang et. al., Nat. Comm. 2018).
Both Drs. Mahajan and Wakatsuki are members of Stanford BioX and ChEM-H, interdisciplinary institutes encompassing three Stanford Schools: Medicine, Chemistry, and Engineering. This provides a truly interdisciplinary research environment at the crossroad of medical science, structural biology and state-of-the art bioimaging technologies. The two groups collaborate closely on structural biology research on eye disease proteins. See one of our recent publications on the structure-function investigation of a cysteine protease: Calpain-5 (Velez et al. Cell Reports 2020). Other ophthalmologic structural biology work includes: 1) targeted structure-functionomics for eye diseases; and 2) structure-based drug design for retinal degeneration.
SLAC provides state-of-the-art multi-modal structural biology technologies covering wide range of spatiotemporal resolutions. SLAC hosts large scale infrastructures: SSRL Structural Molecular Biology (SMB), and Linac Coherent Light Source (LC/LS) providing synchrotron and X-ray beams for crystallography, scattering and spectroscopy, and Stanford-SLAC CryoEM Center (S2C2) providing access to the cryoelectron microscopy (CryoEM) instruments for both single particle structural analysis and tomography (CryoET).
- Ph.D. or equivalent degree in the relevant fields within the last 3 years.
- English proficiency is mandatory.
- Familiarities with one or more of structural biology techniques, including X-ray crystallography, small angle X-ray scattering, cryoEM/ET, biocomputation, and hybrid methods.
- Strong background and experiences in sample preparation and characterization.
- The applicant must be a good team player.
- Experiences in scientific writing and grant application to US funding agencies are plus.
- Updated CV
- Cover Letter
- References with contact information