Interested applicants should send the required application materials to: Contact: C. M. Weyand, MD, PhD E-mail: firstname.lastname@example.org
A postdoctoral fellow position is available in Immunology at Stanford University in the laboratory of C. M. Weyand. The focus of the Weyand lab is to use humanized mouse models to discover and understand how autoimmune inflammation facilitates tissue and organ damage. We are particularly interested in how telomere biology, the cells’ metabolic program and the DNA repair machinery contribute to abnormal immune responses. Our disease models are rheumatoid arthritis, vasculitis and coronary artery disease. Recent publications form the lab: 1. Metabolic control of the scaffold protein TKS5 in tissue-invasive, proinflammatory T cells. Shen Y, Wen Z, Li Y, Matteson EL, Hong J, Goronzy JJ, Weyand CM. Nat Immunol. 2017 Sep;18(9):1025-103 2. Pyruvate controls the checkpoint inhibitor PD-L1 and suppresses T cell immunity. Watanabe R, Shirai T, Namkoong H, Zhang H, Berry GJ, Wallis BB, Schaefgen B, Harrison DG, Tremmel JA, Giacomini JC, Goronzy JJ, Weyand CM. J Clin Invest. 2017 Jun 30;127(7):2725-2738 3. Deficient Activity of the Nuclease MRE11A Induces T Cell Aging and Promotes Arthritogenic Effector Functions in Patients with Rheumatoid Arthritis. Li Y, Shen Y, Hohensinner P, Ju J, Wen Z, Goodman SB, Zhang H, Goronzy JJ, Weyand CM. Immunity. 2016 Oct 18;45(4):903-916 We use discovery approaches to pinpoint alterations that occur during immune-mediated inflammation and as cells enter the senescence program. We have established an array of functional assays and proceed with mechanistic investigation by altering the expression of candidate genes. The lab is part of the Division of Immunology and Rheumatology and all projects have a strong translational component in that most assay systems involve human cell populations.
- Candidates should have a recent PhD degree in immunology, cell biology or a related field.
- Experience with mouse models of human disease, cell signaling, molecular imaging technologies would be an advantage.
- Curriculum vitae
- Short statement describing previous research experience and future goals
- Contact information of three referees