Interested applicants should submit by email the required application materials to Tanja A. Gruber, M.D., Ph.D., Chief, Division of Hematology Oncology Stem Cell Transplant and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine. Email: firstname.lastname@example.org.
Postdoctoral fellowship opportunity
Immunotherapies Targeting Pediatric AML
Laboratory of Tanja Andrea Gruber, M.D., Ph.D. (Pediatrics, Stanford Cancer Institute)
Division of Hematology Oncology Stem Cell Transplant and Regenerative Medicine
Department of Pediatrics
An opportunity is available for a highly motivated postdoctoral fellow who is interested in immunotherapeutic approaches for fusion oncogene driven AML towards a career in academics, biotechnology or pharmaceutical industry. The applicant should have a strong background in cancer biology, molecular biology, immunology, and preferably with experience working with mammalian cells and mouse models of cancer, especially leukemia. There will be opportunities to work with physicians, translational researchers, and scientists.
Primary human hematopoietic and leukemia cells, and an established humanized mouse model will be used. Technologies in the lab include standard biochemistry techniques (Western blot analysis, real-time PCR, immunoprecipitations, cloning), FACs/sorting, colony assays, lentiviral and retroviral transductions, transplantation experiments, xenograft models, peptide stimulation assays, single cell sequencing, and RNA-seq. Knowledge in bioinformatics would be helpful for sequencing analyses.
The intent of these studies is to determine the immunogenicity of tumor associated antigens identified in our humanized mouse model as well as the characterization of expanded TCR clones. Additional avenues of study will be to identify potential CART targets for pediatric AML using sequencing datasets followed by functional validation in murine models. Our long-term goals are to utilize this information to develop cellular therapies for pediatric AML.
- This position is for postdoctoral fellows who have received a Ph.D. in molecular biology, cellular biology, or immunology and have completed their Ph.D. and graduate level training within the past 5 years.
- Experience in immunotherapy and cell and animal models of leukemia or cancer are preferred.
- The candidate is expected to be able to work independently and as part of a team.
- We are looking for individuals with excellent communication, teamwork, data processing, problem solving, written, and oral presentation skills.
- U.S. Citizenship, Green Card or Permanent Residency is not required.
- A curriculum vita
- Letter of interest
- Contact information for 3 references