Email inquiries and materials to Olivia Martinez (email@example.com).
The laboratory of Olivia Martinez is seeking an outstanding and motivated post doctoral fellow to study the immune response to viruses and/or allogeneic tissues. The successful candidate will join a team investigating viral immunity (with emphasis on T cells and NK cells) and the pathogenesis of EBV-associated B cell lymphomas. We are interested in characterizing the host immune response to EBV, CMV, and SARS-CoV-2 to distinguish features that are associated with control of the virus or that result in pathologies including COVID-19, MIS-C, and post-transplant viral disease. Projects that are available include:
1) analysis of the diversity of T cell receptor (TCR) usage in the response to EBV, CMV, and SARS-CoV-2 through the use of next generation sequencing and single cell approaches to evaluate T cell phenotype and function.
2) high dimensional characterization of the natural killer (NK) cell populations that participate in the response to virus.
3) determining the role of the viral protein LMP1 in activation of the PI3K/Akt/mTOR pathway and the effect of targeting this pathway in EBV-associated B cell lymphoma development.
4) investigating the role of myeloid cells in the immune response to composite tissue grafts and the use of nanoparticles to inhibit graft rejection.
Studies are NIH-sponsored. Human immunology projects utilize cell lines as well as existing extensive repositories of human blood and tissue samples. Animal models of transplant immunology and tumor immunology are also established in the lab.
- We seek a candidate who is independent, self-motivated, organized, and with good oral and written communication skills.
- The successful candidate will have experience in high dimensional methodologies including mass cytometry (CyTOF), T cell receptor repertoire analysis, viral genomics or other related approaches to assess immune cell diversity and function.
- The candidate will be a recent PhD in a relevant field (immunology, virology, molecular biology or related) and prior first author publications.
- Experience in sterile tissue culture techniques, flow cytometry, cytometry time of flight and molecular biology techniques and prior experience in basic immunology, transplant immunology, or cancer immunology is a plus.
- A statement of research interests and reasons for applying for this position
- Selected candidates will be asked to participate in a Skype interview and three letters of reference may be requested after the interview