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Postdoctoral Associate in Antiviral Drug Design
The Lin Lab in the Departments of Bioengineering and Neurobiology is seeking a talented postdoc to develop small-molecule antiviral drugs for pandemic RNA viruses, including SARSCoV2 and other coronaviruses.
The Lin Lab has generated a family of orally bioavailable SARSCoV2 drugs based on a lead molecule developed and published online in 2020 (https://www.biorxiv.org/content/10.1101/2020.09.15.275891v2). Recent compounds in this family have demonstrated superior antiviral efficacy to nirmatrelvir (the antiviral component in Paxlovid) and the ability to inhibit viral mutants that resist Paxlovid. The Lin Lab recently received 5 years of funding as part of a NIH AViDD program to develop a family of inhibitors for coronaviruses and other RNA viruses.
This position offers postdocs an unique training opportunity in rational development of small molecular antivirals in collaboration with preeminent AviDD program project labs and expert knowledge centers at Stanford. The postdoc will perform structure-guided drug design, high-throughput drug screening (in collaboration with the laboratory of Matthew Bogyo), in vitro enzymatic assays, in-cell drug efficacy screening, drug-protein co-crystallography (with support from the Stanford Macromolecular Knowledge Center), and BSL3 antiviral assays in cells and lung organoids (in collaboration with the laboratories of Catherine Blish and Shirit Einav).
The project is currently supported by public grants and is thus covered by standard Stanford policies for inventorship and commercialization.
- PhD in chemistry or biochemistry, or equivalent field.
- Experience with at least four of the following: molecular cloning, protein purification, enzymatic assays, protein crystallography, synthetic chemistry.
- Strong oral and written communication skills.
- Proven ability to think creatively and work collaboratively.
- PDFs of first-author publications