We are interested in understanding how altered cellular metabolism drives tumorigenesis and identifying metabolic liabilities amenable to therapeutic targeting. Recently, the oncometabolite hypothesis of cellular transformation has emerged as a central mechanism of oncogenesis. According to this concept, excess accumulation of intermediary metabolites such as succinate, 2-hydroxygluterate, and fumarate that result from altered succinate dehydrogenase (SDH), isocitrate dehydrogenase (IDH) or fumarate hydratase (FH) function, respectively, drive pathogenic epigenetic cellular reprogramming and tumor formation. However, model systems to interrogate the oncometabolite hypothesis and identify therapeutic targets are lacking. To address this critical need, the successful applicant will develop new (human and mouse tumor-based) and leverage established (PMID: 35235785) models of succinate dehydrogenase (SDH)-deficient tumorigenesis. These models will be used for mechanistic investigation and to establish high throughput chemical and genetic discovery platforms. This work will have substantial impact on our fundamental understanding of tumor formation and uncover new treatment avenues.
- Completion of a doctoral degree.
- The qualified candidate will work in a highly collaborative and rigorous research environment.
- Excellent interpersonal skills, scientific curiosity, motivation and ambition are critical attributes for the successful candidate.
- The primary research skill-sets needed are a strong background in molecular and cellular biology.
- Experience with cancer, stem-cell and/or bioinformatic research are highly preferred.
- A background in organoid, primary tumor culture and/or epigenetic research are considered strengths.
- A record of scientific productivity is valued.
- An interest in being mentored for a career in academia as well as in mentoring younger trainees is desired.
- Provide a curriculum vitae with a list of publications and the contact information for two references.
- A cover letter is recommended.