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Open Postdoctoral position, faculty mentor Justin Annes

Important Info

Faculty Sponsor (Last, First Name): 
Annes, Justin
Stanford Departments and Centers: 
Med: Endocrin, Geronot & Metab
Postdoc Appointment Term: 
Renewed Annually, up to 5 years
Appointment Start Date: 
Spring/Summer of 2023
Group or Departmental Website: 
https://med.stanford.edu/annes-lab.html
How to Submit Application Materials: 

Email: Jannes@stanford.edu

Does this position pay above the required minimum?: 
No. The expected base pay for this position is the Stanford University required minimum for all postdoctoral scholars appointed through the Office of Postdoctoral Affairs. The FY23 minimum is $68,238.

We are interested in understanding how altered cellular metabolism drives tumorigenesis and identifying metabolic liabilities amenable to therapeutic targeting. Recently, the oncometabolite hypothesis of cellular transformation has emerged as a central mechanism of oncogenesis. According to this concept, excess accumulation of intermediary metabolites such as succinate, 2-hydroxygluterate, and fumarate that result from altered succinate dehydrogenase (SDH), isocitrate dehydrogenase (IDH) or fumarate hydratase (FH) function, respectively, drive pathogenic epigenetic cellular reprogramming and tumor formation. However, model systems to interrogate the oncometabolite hypothesis and identify therapeutic targets are lacking. To address this critical need, the successful applicant will develop new (human and mouse tumor-based) and leverage established (PMID: 35235785) models of succinate dehydrogenase (SDH)-deficient tumorigenesis. These models will be used for mechanistic investigation and to establish high throughput chemical and genetic discovery platforms. This work will have substantial impact on our fundamental understanding of tumor formation and uncover new treatment avenues.

Required Qualifications: 
  • Completion of a doctoral degree.
  • The qualified candidate will work in a highly collaborative and rigorous research environment.
  • Excellent interpersonal skills, scientific curiosity, motivation and ambition are critical attributes for the successful candidate.
  • The primary research skill-sets needed are a strong background in molecular and cellular biology.
  • Experience with cancer, stem-cell and/or bioinformatic research are highly preferred.
  • A background in organoid, primary tumor culture and/or epigenetic research are considered strengths.
  • A record of scientific productivity is valued.
  • An interest in being mentored for a career in academia as well as in mentoring younger trainees is desired.
Required Application Materials: 
  • Provide a curriculum vitae with a list of publications and the contact information for two references.
  • A cover letter is recommended.

 

Stanford is an equal opportunity employer and all qualified applicants will receive consideration without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, or any other characteristic protected by law.