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I am a Professor of Medicine-Oncology and Pathology and the Director of TRAM, ARTS and CTNT Programs.
My laboratory studies how oncogenes such as MYC initiate and maintain cancer. In particular we have shown that shutting down oncogenes even for a brief time can revese cancer or elicit "Oncogene Addiction." For a recent review of our work please see:
The MYC oncogene - the grand orchestrator of cancer growth and immune evasion Nature Reviews Clinical Oncology, 2022
My laboratory is studying basic mechanisms of Oncogene Addiction, the role of Self-renewal/Stemness, Metabolism, Host Immune System, Protein
Biogenesis, Microbiome, Extracellular Vesicles.
We are developing novel therapuetics using small molecules, nanoparticles, proteins/peptides that can be used to target oncogenes and/or restore the immune response against cancer.
We are developing new diagnostic and imaging agents using PET, Mass Spec, Nanoproteomics, MIcrofluidics.
For recent examples of our published work please see: Casey et al, Science, 2016; Gouw et al, Cell Metabolism, 2019; Dhanasekaran et al eLife, 2020; Swaminathan et al, Nat Comm 2020.
- PhD, MD or MD/PhD
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