Candidates should submit the required application materials to David Cornfield, MD: email@example.com
The Cornfield Lab at Stanford University School of Medicine, Department of Pediatrics is looking for a talented postdoctoral fellow to lead a new NIH-funded project aimed to define the role of lung pericytess in regulating pulmonary vascular growth, tone, and remodeling. Our prior studies employed single cell RNA sequencing to define developmental diversity in mesenchymal cell phenotype during late embryonic and early postnatal life. These studies identified a potential role for hypoxia-inducible-factor (HIF) signaling in pericytes as essential for postnatal angiogenesis and alveolarization. The successful candidate will lead a project that leverages single cell RNA sequencing, ChIP-sequencing, lineage tracing, and genetic mouse models containing cell-specific, inducible deletions of key proteins within the HIF pathway to define the role of lung pericytes in regulating pulmonary vascular growth and function. This project will include close collaboration with the Alvira lab (https://med.stanford.edu/alviralab.html) and other Principal Investigators within the Center for Excellence in Pulmonary Biology (https://med.stanford.edu/cepb.html). The long-term goal of the Cornfield lab is to leverage knowledge of the fundamental pathways that promote pulmonary vascular development into novel therapies to stimulate lung growth and treat pathologic pulmonary vascular remodeling in infants and children.
Candidates must have a PhD or MD/PhD with expertise in cell, molecular, or developmental biology, and past experience using mouse models of disease. Priority will be given to applicants with prior training in pulmonary or vascular biology, or candidates with expertise in single cell transcriptomics. Expertise in primary cell isolation and culture, FACS, confocal imaging, and mouse genetics is desired. The ideal candidate will demonstrate enthusiasm, passion for research, intellectual creativity, and a history of working well in teams.
- Cover letter
- Contact information for three references