Open Postdoctoral position, faculty mentor David Cornfield

The Cornfield Lab at Stanford University School of Medicine, Department of Pediatrics  is looking for a talented postdoctoral fellow to lead a new NIH-funded project aimed to define the role of lung pericytess in regulating pulmonary vascular growth, tone, and remodeling. Our prior studies employed single cell RNA sequencing to define developmental diversity in mesenchymal cell phenotype during late embryonic and early postnatal life. These studies identified a potential role for hypoxia-inducible-factor (HIF) signaling in pericytes as essential for postnatal angiogenesis and alveolarization.    The successful candidate will lead a project that leverages single cell RNA sequencing, ChIP-sequencing, lineage tracing, and genetic mouse models containing cell-specific, inducible deletions of key proteins within the HIF pathway  to define the role of lung pericytes in regulating pulmonary vascular growth and function. This project will include close collaboration with the Alvira lab (https://med.stanford.edu/alviralab.html) and other Principal Investigators within the Center for Excellence in Pulmonary Biology (https://med.stanford.edu/cepb.html). The long-term goal of the Cornfield lab is to leverage knowledge of the fundamental pathways that promote pulmonary vascular development into novel therapies to stimulate lung growth and treat pathologic pulmonary vascular remodeling in infants and children.