Please submit applications to our Education Manager Ms. Taranjit Bains email@example.com with subject line "Postdoctoral position in Dobberfuhl lab"
The Dobberfuhl lab is seeking a postdoctoral scholar in the Department of Urology at Stanford University. Starting in 2019, over 300 women and men suffering from lower urinary tract dysfunction have been enrolled into the WHSDM Study (Funding: Stanford Women's Health & Sex Differences in Medicine & NIH LRPCR 1L30DK115056-01). This is a prospective observational cohort of men and women enrolled by Dr. Dobberfuhl (PD/PI, Assistant Professor of Urology) and her collaborators (Co-I Dr. Bertha Chen Professor of Obstetrics & Gynecology and Co-I Dr. Elizabeth Kidd Associate Professor of Radiation Oncology). The goal of this research is to study gender related differences in bladder function that occur in men and women with lower urinary tract dysfunction. The conditions we are studying in Aim 1 include: overactive bladder, underactive bladder, urinary retention, urgency incontinence, recurrent urinary tract infection (UTI), interstitial cystitis / bladder pain syndrome (IC/BPS), prostatitis, and radiation cystitis. In Aim 2 we assess changes in bladder function which occur over time in women with cervical or endometrial cancer treated with radiotherapy.
For the present postdoctoral scholar position, we are seeking a candidate who has a Ph.D. with a focus on molecular biology, biochemistry, cell biology or pharmacology. Using an existing clinical research electronic database and bio-bank of over 3,000 aliquots of urine from clinical subjects with the above conditions, we are seeking to identify novel molecular mechanisms and prognosticators of treatment response in women with interstitial cystitis / bladder pain syndrome (IC/BPS). The clinical covariates and bio-repository of specimens generated by the WHSDM cohort will be used to test novel research hypotheses via nested observational cohort methods, and specimens pooled with other participants who have similar lower urinary tract dysfunctions to improve discovery, verification and cross-validation of potential urinary biomarkers. The postdoctoral scholar will be responsible for oversight of the WHSDM bio-bank, and should bring an expertise in molecular biology techniques to confirm the biologic plausibility of molecular signaling pathways responsible for lower urinary tract dysfunction in IC/BPS. In concert with Dr. Dobberfuhl’s academic and industry collaborators, novel therapeutics implicated in molecular signaling pathways in IC/BPS will be tested using a combination of in-vivo and ex-vivo animal model physiologic techniques along with living human bladder tissues procured from Donor Network West organ donation program. Promising therapeutics will then be brought to clinical trial through Dr. Dobberfuhl’s ongoing clinical trials related to lower urinary tract dysfunction, with a special emphasis on IC/BPS. The postdoctoral scholar will be involved with all of phases of clinical translational research, working with ongoing collaborations, developing NIH proposals with Dr. Dobberfuhl, and will assume the intermediate term goal to apply for NIH F32 individual postdoctoral fellowship funding during the postdoc appointment term.
- The candidate must have a Ph.D. with a focus on molecular biology, biochemistry, cell biology, or pharmacology.
- Experience in:
- (i) clinical translational research;
- (ii) biomarker discovery, verification & validation;
- (iii) molecular and animal models; and
- (iv) pharmacology are highly desirable
- Candidates should also have a strong track record of productive research and publications, as well as excellent written and verbal communication skills.
- The candidate should be highly self-motivated, and be able to work independently as well as collaboratively to bring projects to fruition.
- Curriculum Vitae
- Cover letter describing research interests and qualifications for this position
- Contact information of three referees