Please email the required application materials to Beatrice Raquel Ochoa at email@example.com.
Post Doc Position: Focus on Juvenile Myelomonocytic Leukemia (JMML)
Job Location: Czechowicz and Bertaina Laboratory | Biomedical Innovations Building, Stanford University, Stanford, CA.
The Czechowicz and Bertaina Laboratories have formed an exciting collaboration and have an opening for a creative, collaborative and motivated postdoctoral fellow with an interest in leukemia, hematopoiesis, and bone marrow transplantation (BMT). The successful candidate will join the Department of Pediatrics, Division of Stem Cell Transplantation and Regenerative Medicine at Stanford University School of Medicine and will be expected to lead several exciting and innovative translational projects focusing specifically on juvenile myelomonocytic leukemia (JMML), a particularly devastating pediatric leukemia.
Our laboratories have extensive experience in hematopoiesis and leukemia research, and we have previously conducted complementary pioneering work on improving bone marrow transplantation through creation of novel conditioning methods and enhanced hematopoietic grafts. We have previously demonstrated that hematopoietic stem cell depletion is a critical component to donor cell engraftment and several agents that enable safe and targeted conditioning are now in development based upon our work. We are now using these agents as probes to understand underlying hematopoietic biology and are applying these to the treatment of candidate diseases of great need, with a focus on using these as curative agents for pediatric leukemia as we have found these agents also target leukemia initiating cells.
The postdoctoral fellow selected to join our laboratories will create, aid and use the novel conditioning agents we have developed to further understand and improve bone marrow transplantation, with specific focus on optimizing transplantation in mouse and xenograft models of juvenile myelomonocytic leukemia (JMML). We anticipate this work to lead to a subsequent clinical trial applying these therapies to JMML patients.
Potential specific project aims include:
- Studying the effects of our unique antibodies alone and in combination with BMT in diseased and humanized-mouse leukemia models
- Increasing our understanding of leukemia composition and evolution in order to identify new targets and treatment strategies
- Developing and applying other novel technologies to target these cancerous cells for eradication prior to BMT
- The scope of our research employs a wide range for techniques including tissue culture, in vivo mouse disease models, humanized-mouse models, bone marrow transplantation, high-through put sequencing, flow cytometry, molecular cloning, RNASeq/single cell transcriptome analysis, proteomics, confocal microscopy and lentiviral transduction.
The postdoctoral fellow will have individualized mentorship tailored to his or her personal career and publications goals including regular meetings with Dr. Czechowicz and Dr. Bertaina to guarantee a successful fellowship. The fellow will also engage in a vibrant scientific discourse with the spectacular Stanford stem cell community and enjoy a positive and impact-oriented work environment. The fellow will also be expected to occasionally teach or mentor students and to help foster a productive learning environment, and additionally the fellow will have opportunities for clinical and translational exposure if interested.
It is intended that the postdoctoral fellow will contribute to making important biomedical discoveries, and simultaneous grow through this position and develop the skills necessary to become a strong contributor to the advancement of science and/or medicine. This is an ideal role for fellows looking for subsequent opportunities in academia, industry or other associated business areas.
Postdoctoral fellow candidates must have a PhD, MD or MD/PhD. Candidates must have gained knowledge in hematopoiesis and cancer research, and be interested in bone marrow transplantation. In order to be considered, candidates should have:
· demonstrated the ability to work independently
· shown initiative and prior research productivity
· attention to details
· strong motivation to explore new techniques and concepts
· collaborative team spirit
· excellent communication skills
· positive attitude
· adherence to highest ethical principles
Candidates with prior experience in cancer biology, hematopoiesis, leukemia, cell therapy, and/or bone marrow transplantation are strongly encouraged to apply.
- An updated CV
- Complete contact information for three references
- Short cover letter describing past research experience, career goals and a statement of future research interest (1 page)