Our lab is leveraging a new methylation profiler that enriches methylation markers genome-wide to find diagnostic, prognostic markers for cancer and other diseases. The postdoctoral fellow should be interested in early cancer detection and/or minimally invasive approaches for molecular diagnostics with a specific focus on methylation profiling of large datasets.
Mitochondrial dysfunction is commonly associated with aging and age-related chronic diseases. A major goal of our research is to understand how mitochondrial dysfunction arises during aging and contributes to the pathogenesis of a broad spectrum of age-related diseases, from cancer to neurodegenerative diseases and sarcopenia. An overarching hypothesis is that aging and age-related diseases share fundamental molecular and cellular mechanisms. Thus, by targeting the molecular drivers of aging, we can develop new understandings and therapies for many age-related diseases.
Dr. Cong's group is developing novel technology for genome editing and single-cell genomics, leveraging scalable methods inspired by data science and machine learning and artificial intelligence.
Environmental microbiology (e.g. diatoms, algae) and synthetic biology
Topics: Nitrogen fixation, lipid biosynthesis and transprot, cellular endosymbiosis, nonmodel organisms
Application areas: Fertilizers, Biofuels
Research in the Pollack lab centers on translational genomics, with a current focus on diseases of the prostate. The lab employs next-generation sequencing, single-cell genomics, genome editing, and cell/tissue-based modeling to uncover disease mechanisms, biomarkers and therapeutic targets.
One of the key ways that the gut microbiome impacts human health is through the production of bioactive metabolites. By understanding how microbes produce these molecules, we aim to develop new approaches to promote human health and treat disease. Our laboratory employs bacterial genetics, metabolomics, and gnotobiotic mouse colonization to uncover the chemistry that underlies host-microbe interactions in the gut.
The Schuele lab works on gene discovery and novel stem cell technologies to generate stem cell models from patients with Parkinson’s disease and related disorders to understand the underlying causes of neurodegeneration. Our projects range from clinical genetic family studies and human stem cell modeling of neurocircuits to translational pre-clinical gene therapy studies in Parkinson’s disease.
Chromatin regulators are highly altered in diseases. Of interest, these proteins are easily targetable by drugs. Furthermore, the plasticity of epigenetic events makes them a powerful target for new therapeutic strategies and reversion of disease phenotype. Histone and DNA modifications influence many processes including transcription, replication, genomic stability and cell division, which are altered in diseases. Therefore, understanding the molecular basis of chromatin modifiers in both normal and pathological cells could help us frame new potential biomarkers and targeted therapies.
