PRISM supports all faculty in recruiting postdocs. The faculty listed on this page have expressed special interest in the PRISM program and may be actively recruiting. This is one of many ways to identify potential postdoc mentors; also review the guidance and links in the PRISM Application Guide for other ways to explore Stanford faculty. As you look for potential postdoc mentors, consider how faculty research interests align with your own.
Faculty: to create a profile, click "Log In" at the top right corner, then the "PRISM Faculty Opt In" button below. To edit an existing profile, click "Log In" at the top right corner, then the "Edit" button under your name/department/URL.
PRISM mentor | Research Interests |
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Gozde Durmus Radiology
Radiology
Last Updated: August 10, 2020 |
Our lab's research lies at the interface of biology, engineering, nanotechnology, and medicine. We develop and apply translational micro/nanotechnologies to study cellular heterogeneity and complex biological systems for single cell analysis and precision medicine. At this unique nexus, we apply key biological principles to design engineering platforms. Our research philosophy is to apply these platforms to fundamentally understand and address the mechanisms of disease (i.e., cancer, infections).
We are seeking open and honest, creative, dedicated, and team-oriented individuals to join our research team. Our lab prioritizes inclusion and diversity to achieve excellence in research and to foster an intellectual climate that is welcoming and nurturing. Two positions are available for energetic, self-driven and passionate postdoctoral fellow candidates. Applicants are expected to be technically competent in a discipline relevant to our mission and vision. |
Glaivy Batsuli Pediatrics
Pediatrics
Last Updated: October 02, 2023 |
The Batsuli Lab focuses on elucidating mechanisms of the immune response to blood coagulation proteins deficient in patients with inherited bleeding disorders, specifically hemophilia. Hemophilia is a rare bleeding disorders caused by low or absent clotting proteins factor VIII or factor IX that affects an individual's risk of bleeding. Our lab seeks to better understand the interaction of factor proteins with antigen presenting cells that result in antibody development against factor replacement therapies in order to develop therapeutic strategies that evade these immune responses and induce tolerance. The Batsuli Lab supports a collaborative and supportive research environment that engages in team science. |
Gavin Sherlock Genetics
Genetics
Last Updated: February 01, 2023 |
The Sherlock lab uses experimental approaches to understand the evolutionary process, specifically interested in i) what's the rate of beneficial mutation, ii) what is the distribution of fitness effects of beneficial mutations, iii) what are the identities of beneficial mutations (and are they gain or loss of function, are they recessive, dominant or overdominant, are the genic or regulatory?) and iv) how do each of these change as a function of genotype, ploidy and environment. We are also interested in how mutations that are beneficial in one environment fare in others, to explore the trade-offs that inevitably occur when fitness increases in a specific environment, and we are interested in exploring at what level experimental evolution can be deterministic, and at what level it is stochastic. We typically use short-term continuous (chemostat) and serial batch culture experiments in conjunction with lineage tracking and high throughput sequencing to understand the adaptive changes that occur in yeast in response to selective pressures as they evolve in vitro.
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Gavin Sherlock Genetics
Genetics
Last Updated: December 01, 2021 |
The Sherlock lab uses experimental approaches to understand the evolutionary process, specifically interested in i) the beneficial mutation rate, ii) the distribution of fitness effects (DFE) of beneficial mutations, iii) the identities of beneficial mutations (are they gain or loss of function, are they recessive, dominant or overdominant, are the genic or regulatory?) and iv) how do each of these change as a function of genotype, ploidy and environment. We are also interested in how mutations that are beneficial in one environment fare in others (pleiotropy), and we are interested in exploring at what level experimental evolution can be deterministic, and at what level it is stochastic. We typically use serial batch culture experiments in conjunction with lineage tracking and high throughput sequencing to understand the adaptive changes that occur in yeast in response to selective pressures as they evolve in vitro.
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Gary Peltz Anesthes, Periop & Pain Med
Anesthes, Periop & Pain Med
Last Updated: August 15, 2023 |
Our laboratory develops and applies state of the art genetic, genomic and stem cell technologies to its research programs. These methodologies are used to discover the mechanisms mediating disease susceptibility and drug response, and to develop new therapies. As one example, we developed a novel computational genetic analysis method, which has identified genetic factors affecting disease susceptibility and biomedical responses in mouse models. Over 25 genetic factors affecting susceptibility to drug addiction, chronic pain, infectious diseases, and others have already been identified. We recently developed a novel AI for mosue genetic discovery and have received two NIH grants for advancing AI-based genetic discovery.
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Gary Peltz Chemical and Systems Biology
Chemical and Systems Biology
Last Updated: January 12, 2022 |
The Peltz laboratory develops and uses state of the art genetic, genomic and stem cell technologies in its research programs. These methodologies are used to discover the mechanisms mediating disease susceptibility and drug response, and to develop new therapies. As one example, we developed a novel computational genetic analysis method, which has identified genetic factors affecting disease susceptibility and biomedical responses in mouse models. One of the genetic findings is the basis for an ongoing clinical trial that tests a new therapy for preventing opiate withdrawal from occuring in babies born to mothers that take opiates. Over 25 genetic factors affecting susceptibility to drug addiction, chronic pain, infectious diseases, and others have been identified. An ongoing effort is now analyzing 10000 biomedical responses in panels of inbred mouse strains. Single-cell RNA sequencing and metabolic analysis are used to identify developmental and disease-causing pathways. Stem cell-based methods for liver engineering are also used. As examples of this, the Peltz lab has produced mice with humanized livers that are used to improve drug safety; developed methods to engineer human liver from adipocyte stem cells; and to produce human liver organoids from stem cells, which are used for studying the pathogenesis of human genetic liver diseases.
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Flora Novotny Rutaganira Biochemistry, Developmental Biology
Biochemistry, Developmental Biology
Last Updated: August 15, 2023 |
The FUNR Lab, lead by Flora Rutaganira uses choanoflagellates—the closest living single-celled relatives to animals—to study the origin of animal cell communication. We apply chemical, genetic, and cell biological tools to probe choanoflagellate cell-cell communication. We hope that our research has implications for understanding not only animal cell signaling, but also the origin of multicellularity in animals. |
Flora Novotny Rutaganira Biochemistry, Developmental Biology
Biochemistry, Developmental Biology
Last Updated: August 15, 2023 |
The FUNR Lab, lead by Flora Rutaganira uses choanoflagellates—the closest living single-celled relatives to animals—to study the origin of animal cell communication. We apply chemical, genetic, and cell biological tools to probe choanoflagellate cell-cell communication. We hope that our research has implications for understanding not only animal cell signaling, but also the origin of multicellularity in animals. |
Fatima Rodriguez Med: Cardiovascular Medicine
Med: Cardiovascular Medicine
Last Updated: November 01, 2022 |
The Health Equity Advancement through Research and Technology (HEART) Lab, led by Dr. Fatima Rodriguez, aims to develop innovative approaches to understanding and eliminating cardiovascular disease health disparities across diverse and understudied populations. Prior and current projects seek to identify the source of inequities in cardiovascular disease by race, ethnicity, language, sex, age, and more. We have documented extensive barriers to guideline adherence to cardiovascular prevention recommendations and how these result in adverse clinical outcomes. Several projects also center around Hispanic cardiovascular health and prevention. We have published work highlighting the importance of disaggregation of Hispanic individuals by background, acculturation, and socioeconomic factors. We are also interested in using novel AI/machine learning approaches in the electronic health record to improve cardiovascular risk prediction and treatment for understudied populations, including historically marginalized racial/ethnic patient groups and older adults. Other areas of focus include promoting digital health equity by studying telemedicine access and utilization, especially after the expansion of virtual care following the COVID-19 pandemic. Our research also explores reasons and solutions to increase workforce diversity in cardiovascular medicine and representation of diverse groups in guideline-informing clinical trials. |
Everett Moding Radiation Oncology
Radiation Oncology
Last Updated: March 14, 2022 |
We perform translational cancer research by analyzing human tissue and blood samples with next-generation sequencing to understand the genetic underpinnings and expression signatures that determine treatment response and resistance. We use genetically engineered mouse models to validate our findings, perform mechanistic experiments, and test new therapies. Our ultimate goal is to translate our findings to the clinic to improve outcomes for patients with cancer. |
Everett Meyer Med: Bone Marrow Transplant, Stanford Cancer Center
Med: Bone Marrow Transplant, Stanford Cancer Center
Last Updated: August 13, 2020 |
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Everett Meyer Med: Bone Marrow Transplant, Stanford Cancer Center
Med: Bone Marrow Transplant, Stanford Cancer Center
Last Updated: August 13, 2020 |
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Eugene Butcher Pathology
Pathology
Last Updated: July 13, 2022 |
We are interested in fundamental aspects of cell-cell recognition, migration and development with the mammalian immune and vascular systems as models. We use molecular, genetic and single cell transcriptomic and mass cytometric approaches to study the development and trafficking of lymphocytes, NK cells and dendritic cells and their role in immune function in health and diseases. |
Erin Mordecai Biology, Woods Institute
Biology, Woods Institute
Last Updated: January 12, 2022 |
Our research investigates how environmental changes like climate and land use change are affecting infectious diseases in humans and wildlife. We use tools from disease ecology, including mathematical and statistical models, health surveillance data, remotely sensed data, laboratory experiments, and field surveys to better understand the mechanisms by which changes in temperature and habitat affect vectors and disease transmission. |
Erin Mordecai Biology, Woods Institute
Biology, Woods Institute
Last Updated: January 12, 2022 |
Our research investigates how environmental changes like climate and land use change are affecting infectious diseases in humans and wildlife. We use tools from disease ecology, including mathematical and statistical models, health surveillance data, remotely sensed data, laboratory experiments, and field surveys to better understand the mechanisms by which changes in temperature and habitat affect vectors and disease transmission. |
Eric Pop Electrical Engineering, Materials Sci & Engineering
Electrical Engineering, Materials Sci & Engineering
Last Updated: January 27, 2023 |
The Pop Lab is a research group led by Prof. Eric Pop in Electrical Engineering (EE) and Materials Science & Engineering (MSE) at Stanford University. We are located in the Paul Allen Center for Integrated Systems (CIS), working in the Stanford Nanofabrication Facility (SNF) and the Stanford Nano Shared Facilities (SNSF). We are affiliated with the Stanford SystemX Alliance and the Non-Volatile Memory Technology Research Initiative (NMTRI). Our research is at the intersection of nanoelectronics and nanoscale energy conversion, exploring topics such as:
Our work includes nanofabrication, characterization, and multiscale simulations. On-campus collaborations include Materials Science, Physics, Chemical and Mechanical Engineering, and off-campus they range from UIUC, UC Davis, Georgia Tech, UT Dallas, Univ. of Tokyo and Singapore (NUS), to TU Wien, Univ. Bologna and Poli Milano. To learn more about us, please visit http://poplab.stanford.edu |
Eric Pop Electrical Engineering, Materials Sci & Engineering
Electrical Engineering, Materials Sci & Engineering
Last Updated: January 27, 2023 |
The Pop Lab is a research group led by Prof. Eric Pop in Electrical Engineering (EE) and Materials Science & Engineering (MSE) at Stanford University. We are located in the Paul Allen Center for Integrated Systems (CIS), working in the Stanford Nanofabrication Facility (SNF) and the Stanford Nano Shared Facilities (SNSF). We are affiliated with the Stanford SystemX Alliance and the Non-Volatile Memory Technology Research Initiative (NMTRI). Our research is at the intersection of nanoelectronics and nanoscale energy conversion, exploring topics such as:
Our work includes nanofabrication, characterization, and multiscale simulations. On-campus collaborations include Materials Science, Physics, Chemical and Mechanical Engineering, and off-campus they range from UIUC, UC Davis, Georgia Tech, UT Dallas, Univ. of Tokyo and Singapore (NUS), to TU Wien, Univ. Bologna and Poli Milano. To learn more about us, please visit http://poplab.stanford.edu |
Eric Kool Chemistry
Chemistry
Last Updated: January 29, 2023 |
The Kool lab uses the tools of chemistry and biology to study the structures, interactions and biological activities of nucleic acids and the enzymes that process them. Molecular design and synthesis play a major role in this work, followed by analysis of structure and function, both in vitro and in living systems. These studies are aimed at gaining a better basic understanding of biology, and applying this knowledge to practical applications in biomedicine. Recent research interests include the development of chemical tools for mapping RNA structure and interactions in cells, methods for stabilization and conjugation of RNAs, and the development of probes of DNA repair pathways and their connections to cancer. |
Eric Gross Anesthes, Periop & Pain Med
Anesthes, Periop & Pain Med
Last Updated: August 11, 2020 |
Our laboratory is developing tools to study genetic variants commonly found in Asians within the basic science laboratory including CRISPR mouse models, drug development/design, and protein chemistry. Most of our laboratory uses basic science techniques to study the cardiovascular system and we are funded through the NIH from NIGMS and NHLBI. Our NIGMS funded project focuses on genetic variants in Asians and developing precision medicine strategies for reducing perioperative organ injury and precision medicine strategies for delivering anesthesia and pain relievers such as opioids. Our NHLBI funded project is to study the cardiopulmonary effects of e-cigarettes in rodents and to further determine how a common genetic variant in East Asians may impact the cellular toxicity of e-cigarettes.
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Eric Darve Mechanical Engineering, Institute for Computational and Mathematical Engineering
Mechanical Engineering, Institute for Computational and Mathematical Engineering
Last Updated: August 15, 2023 |
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Eric Darve Mechanical Engineering, Institute for Computational and Mathematical Engineering
Mechanical Engineering, Institute for Computational and Mathematical Engineering
Last Updated: August 15, 2023 |
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Eric Appel Materials Sci & Engineering, Ped: Endocrinology
Materials Sci & Engineering, Ped: Endocrinology
Last Updated: July 13, 2022 |
We are an interdisciplinary team focusing on generating new biomaterials to tackle healthcare challenges of critical importance to society. We are using these new biomaterials as sustained delivery technologies that can act as tools to better understand fundamental biological processes and to engineer next-generation healthcare solutions.
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Eric Appel Materials Sci & Engineering, Ped: Endocrinology
Materials Sci & Engineering, Ped: Endocrinology
Last Updated: July 13, 2022 |
We are an interdisciplinary team focusing on generating new biomaterials to tackle healthcare challenges of critical importance to society. We are using these new biomaterials as sustained delivery technologies that can act as tools to better understand fundamental biological processes and to engineer next-generation healthcare solutions.
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Elliott White Jr. Earth Energy Env Sciences
Earth Energy Env Sciences
Last Updated: January 26, 2022 |
The coastal margin is a complex socio-ecological landscape that is experiencing more frequent and stronger hazards from the coasts due to global climate change. Saltwater intrusion and Sea level rise (SWISLR) are placing coastal ecosystems under increasing threat, while humans in the coastal margin are pressured to make critical decisions regarding livelihood and well-being. Assessing, predicting, and mitigating the myriad challenges to the coastal margin requires a holistic approach that can integrate knowledge from different disciplines and work at multiple scales. |
Ellen Yeh Biochemistry, Pathology, Microbiology and Immunology
Biochemistry, Pathology, Microbiology and Immunology
Last Updated: July 14, 2022 |
The Yeh Lab studies the apicoplast, a unique plastid organelle in Plasmodium falciparum parasites that cause malaria. We are particularly focused on unbiased chemical and genetic screens to discover new cell biology and therapeutic targets for this important global health disease. Our work highlights the untapped opportunities in exploring divergent biology in non-model organisms, a theme we plan to expand in the lab by studying ocean algae (malaria's cousins!) and their role in the global ecosystem.
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Ellen Yeh Biochemistry, Pathology, Microbiology and Immunology
Biochemistry, Pathology, Microbiology and Immunology
Last Updated: July 14, 2022 |
The Yeh Lab studies the apicoplast, a unique plastid organelle in Plasmodium falciparum parasites that cause malaria. We are particularly focused on unbiased chemical and genetic screens to discover new cell biology and therapeutic targets for this important global health disease. Our work highlights the untapped opportunities in exploring divergent biology in non-model organisms, a theme we plan to expand in the lab by studying ocean algae (malaria's cousins!) and their role in the global ecosystem.
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Ellen Yeh Biochemistry, Pathology, Microbiology and Immunology
Biochemistry, Pathology, Microbiology and Immunology
Last Updated: July 14, 2022 |
The Yeh Lab studies the apicoplast, a unique plastid organelle in Plasmodium falciparum parasites that cause malaria. We are particularly focused on unbiased chemical and genetic screens to discover new cell biology and therapeutic targets for this important global health disease. Our work highlights the untapped opportunities in exploring divergent biology in non-model organisms, a theme we plan to expand in the lab by studying ocean algae (malaria's cousins!) and their role in the global ecosystem.
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Ellen Yeh Pathology, Microbiology and Immunology
Pathology, Microbiology and Immunology
Last Updated: July 12, 2022 |
Environmental microbiology (e.g. diatoms, algae) and synthetic biology Topics: Nitrogen fixation, lipid biosynthesis and transprot, cellular endosymbiosis, nonmodel organisms Application areas: Fertilizers, Biofuels |
Ellen Yeh Pathology, Microbiology and Immunology
Pathology, Microbiology and Immunology
Last Updated: July 12, 2022 |
Environmental microbiology (e.g. diatoms, algae) and synthetic biology Topics: Nitrogen fixation, lipid biosynthesis and transprot, cellular endosymbiosis, nonmodel organisms Application areas: Fertilizers, Biofuels |
Elizabeth Sattely Chemical Engineering
Chemical Engineering
Last Updated: July 13, 2022 |
My laboratory is focused broadly on plant chemistry and is deeply invested in pathway discovery. Despite the important roles of plant natural products in plant and human health, very few complete plant biosynthetic pathways are known. This lack of knowledge limits our understanding of natural product mode of action in plants and prevents access to engineered pathways. New plant genome sequences and synthetic biology tools have enabled three research areas in my lab: 1) methods for accelerating pathway discovery in plants (especially for clinically used therapeutics), and 2) discovering new molecules from plants that are important for plant fitness, and 3) using metabolic engineering in plants as a tool to systematically and quantitatively determine the impact of plant molecules on human and plant health and ultimately optimize plant fitness and crop nutrient load. I am looking for postdocs who are interested in joining an interdisciplinary team of scientists and engineers to discover how plant natural products are made and their mode of action, and develop new tools for engineering biosynthetic pathways. Our vision is to use engineered biosynthesis to reveal mechanisms by which natural products from plants contribute to plant fitness and human health. |
Elizabeth Mormino Neurology & Neurological Sci
Neurology & Neurological Sci
Last Updated: February 23, 2024 |
Alzheimer's disease pathology begins decades before clinical symptoms of dementia are present, providing an important opportunity to understand early disease and the impact of this disease on cognitive aging. We combine multimodal neuroimaging and genetics to determine how AD changes and risk factors influence subtle cognitive decline in older individuals. We have a particular focus on PET imaging of Amyloid and Tau proteins, but also work with structural and functional MRI data. The ultimate goals of our work are to improve our ability to predict who is most at risk for dementia, and to understand the time course of brain changes that occur decades before clinical symptoms are present. We are specifically recruiting trainees with expertise in genetics, neuroimaging, or neuropsychology, to work on large scale multimodal imaging-genetic studies. |
Elizabeth Egan Pediatrics, Microbiology and Immunology
Pediatrics, Microbiology and Immunology
Last Updated: July 13, 2022 |
Malaria is one of the leading causes of childhood morbidity and mortality in the world. The etiologic agent of severe malaria, Plasmodium falciparum, exclusively infects red blood cells during the blood stage of its life cycle, when all of the symptoms of malaria occur. P. falciparum is an obligate intracellular parasite, suggesting that it critically depends on host factors for its biology and pathogenesis. This concept is also supported by population genetic studies, which indicate that humans have evolved certain red cell traits, such as hemoglobinopathies, to protect against malaria. The importance of these host-pathogen interactions raises the possibility that critical red cell factors could serve as targets for new, host-directed therapeutics for malaria. However, our understanding of host determinants for malaria is limited because red cells are enucleated and lack DNA, hindering genetic manipulation. In the Egan laboratory we have surmounted this hurdle by adapting advances from stem cell biology to the study of malaria host factors. Specifically, we have developed approaches to differentiate primary human CD34+ hematopoietic stem/progenitor cells down the erythroid lineage to enucleated red blood cells that can be infected by P. falciparum. This thus gives us access to the nucleated progenitor cells for genetic modification using RNAi and CRISPR-Cas9 genome editing. We are using these methods to develop forward genetic screens to identify novel host factors for malaria, as well as to perform mechanistic studies to understand the specific functions of critical host factors during the developmental cycle of malaria parasites. In addition, the lab has projects focused on understanding human adaptation to malaria using clinical samples. Our long term goal is to explore the possibility of host-directed therapeutics for malaria.
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Elizabeth Egan Pediatrics, Microbiology and Immunology
Pediatrics, Microbiology and Immunology
Last Updated: July 13, 2022 |
Malaria is one of the leading causes of childhood morbidity and mortality in the world. The etiologic agent of severe malaria, Plasmodium falciparum, exclusively infects red blood cells during the blood stage of its life cycle, when all of the symptoms of malaria occur. P. falciparum is an obligate intracellular parasite, suggesting that it critically depends on host factors for its biology and pathogenesis. This concept is also supported by population genetic studies, which indicate that humans have evolved certain red cell traits, such as hemoglobinopathies, to protect against malaria. The importance of these host-pathogen interactions raises the possibility that critical red cell factors could serve as targets for new, host-directed therapeutics for malaria. However, our understanding of host determinants for malaria is limited because red cells are enucleated and lack DNA, hindering genetic manipulation. In the Egan laboratory we have surmounted this hurdle by adapting advances from stem cell biology to the study of malaria host factors. Specifically, we have developed approaches to differentiate primary human CD34+ hematopoietic stem/progenitor cells down the erythroid lineage to enucleated red blood cells that can be infected by P. falciparum. This thus gives us access to the nucleated progenitor cells for genetic modification using RNAi and CRISPR-Cas9 genome editing. We are using these methods to develop forward genetic screens to identify novel host factors for malaria, as well as to perform mechanistic studies to understand the specific functions of critical host factors during the developmental cycle of malaria parasites. In addition, the lab has projects focused on understanding human adaptation to malaria using clinical samples. Our long term goal is to explore the possibility of host-directed therapeutics for malaria.
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Eleni Linos Dermatology, Epidemiology and Population Health
Dermatology, Epidemiology and Population Health
Last Updated: February 23, 2024 |
Our team’s research spans the fields of dermatology, technology and public health. One of our main projects is centered on developing innovative skin cancer prevention interventions using social media. Another project area is the use of shared decision-making, mobile app technology for monitoring and optimal care of low risk skin cancers. We collaborate closely with colleagues in bioinformatics and computer science on use of visual Artificial intelligence methods to skin image monitoring. Additionally, we advocate for diversity and gender equity in medicine by writing both original data articles and perspective pieces on these topics. We collaborate with epidemiologists, clinicians, biostatisticians, basic, computer and social scientists at Stanford University as well as other institutions.
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Eleni Linos Dermatology, Epidemiology and Population Health
Dermatology, Epidemiology and Population Health
Last Updated: February 23, 2024 |
Our team’s research spans the fields of dermatology, technology and public health. One of our main projects is centered on developing innovative skin cancer prevention interventions using social media. Another project area is the use of shared decision-making, mobile app technology for monitoring and optimal care of low risk skin cancers. We collaborate closely with colleagues in bioinformatics and computer science on use of visual Artificial intelligence methods to skin image monitoring. Additionally, we advocate for diversity and gender equity in medicine by writing both original data articles and perspective pieces on these topics. We collaborate with epidemiologists, clinicians, biostatisticians, basic, computer and social scientists at Stanford University as well as other institutions.
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Electron Kebebew Surg: General Surgery
Surg: General Surgery
Last Updated: February 23, 2024 |
The Endocrine Oncology Research Laboratory is engaged in cutting-edge endocrine and neuroendocrine clinical, translational and basic research. Our research is focused on:
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Dylan Dodd Pathology, Microbiology and Immunology
Pathology, Microbiology and Immunology
Last Updated: January 12, 2022 |
One of the key ways that the gut microbiome impacts human health is through the production of bioactive metabolites. By understanding how microbes produce these molecules, we aim to develop new approaches to promote human health and treat disease. Our laboratory employs bacterial genetics, metabolomics, and gnotobiotic mouse colonization to uncover the chemistry that underlies host-microbe interactions in the gut. |
Dylan Dodd Pathology, Microbiology and Immunology
Pathology, Microbiology and Immunology
Last Updated: January 12, 2022 |
One of the key ways that the gut microbiome impacts human health is through the production of bioactive metabolites. By understanding how microbes produce these molecules, we aim to develop new approaches to promote human health and treat disease. Our laboratory employs bacterial genetics, metabolomics, and gnotobiotic mouse colonization to uncover the chemistry that underlies host-microbe interactions in the gut. |
Dustin Schroeder Geophysics
Geophysics
Last Updated: October 21, 2021 |
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Dominique Bergmann Biology
Biology
Last Updated: February 23, 2024 |
Our lab is interested in how stem cell-like populations are created and maintained in developing, environmental responsive tissues. We primarily use the Arabidopsis stomatal lineage for these studies because this epidermal cell lineage distills features common to all tissue development: stomatal precursor cells are chosen from an initially equivalent field, they undergo asymmetric and self-renewing divisions, they communicate among themselves to establish pattern and they terminally differentiate into stable, physiologically important cell-types. In the past decade, we have developed the stomatal lineage into a conceptual and technical framework for the study of cell fate, stem-cell self-renewal and cell polarity. Currently, we are especially interested in: (1) using single-cell technologies to capture transcriptomic and chromatin state information about cells as they transit through various identities (stem cell-like, committed, differentiated, and reprogrammed); (2) using new ‘in vivo biochemical’ approaches to identify transcription factor modules in the nuclear and cell polarity complexes at the plasma membrane, and to determine how these complexes guide changes in cell shape, size and fate; (3) computational modeling of pattern formation in the epidermis, and (4) testing how environmental information impacts developmental choices and robustness. |
Dominique Bergmann Biology
Biology
Last Updated: February 23, 2024 |
The overall goal of my research program is to understand how stem cell-like populations are created and maintained in the context of an intact and environmental responsive tissue. We use the Arabidopsis stomatal lineage for these studies as this epidermal cell lineage distills many of the features common to all tissue development: stomatal precursor cells are chosen from an initially equivalent field, they undergo asymmetric and self-renewing divisions, they communicate among themselves to establish pattern and they terminally differentiate into stable, physiologically important cell-types. In the past decade, we have developed the stomatal lineage into a conceptual and technical framework for the study of cell fate, stem-cell self-renewal and cell polarity. Currently, we are especially interested in: (1) using new single-cell technologies to capture transcriptomic and chromatin state information about cells as they transit through various identities (stem cell-like, committed, differentiated, and reprogrammed); (2) using new ‘in vivo biochemical’ approaches to identify plant-specific cell polarity complexes and how these guide changes in cell shape, size and fate; (3) computational modeling of pattern formation in the epidermis, and (4) testing how environmental information impacts developmental choices and robustness. |
denise monack Microbiology and Immunology
Microbiology and Immunology
Last Updated: January 27, 2023 |
We study how the interactions between enteric bacterial pathogens, the gut microbiota and the immune system influence chronic infection and transmission to new hosts. Salmonella is one of the model pathogens that we study. Salmonella typhi cause systemic diseases such as typhoid fever. we also explore interactions between Salmonella and immune cells, such as macrophages. We have shown that persisting Salmonella exploit the metabolic immune state of alternatively activated macrophages in order to cause chronic infections. We are very interested in human-adapted Salmonella and are trying to understand the evolution of the strains of Salmonella that cause typhoid fever. Recently we have developed a tool to study the genomes of various Salmonella and how the genes contribute to surviving the various stresses that the pathogens encounter during infection, including human macrophages.
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Dean Felsher Med: Oncology
Med: Oncology
Last Updated: January 12, 2022 |
I am a Professor of Medicine-Oncology and Pathology and the Director of TRAM, ARTS and CTNT Programs. My laboratory studies how oncogenes such as MYC initiate and maintain cancer. In partic ular we have shown that shutting down oncogenes even for a brief time can revese cancer or elicit "Oncogene Addiction" For a recent review of our work please see: The MYC oncogene - the grand orchestrator of cancer growth and immune evasion Nature Reviews Clinical Oncology, 2022 Members of my laboratory are studying basic mechanisms of Oncogene Addiction, the role of Self-renewal/Stemness, Metabolism, Host Immune System, Protein We are developing novel therapuetics using small molecules, nanoparticles, proteins/peptides that can be used to target oncogenes and/or restore the immune response against cancer. We are developing new diagnostic and imaging agents using PET, Mass Spec, Nanoproteomics, MIcrofluidics. For recent examples of our work please see: Casey et al, Science, 2016; Gouw et al, Cell Metabolism, 2019; Dhanasekaran et al eLife, 2020; Swaminathan et al, Nat Comm 2020.
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David Schneider Microbiology and Immunology
Microbiology and Immunology
Last Updated: March 12, 2021 |
My group is intersted in preventing sickness following infections. We do this not by limiting microbe load, but by increasing the body's tolerance and resilience to damage. In the past we worked mostly on fruitflies, but have switched to studying mice and humans and focusing on malaria. We try to identify modifiable physiological systems that we can perturb to improve health outcomes.
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David Relman Med: Infectious Diseases
Med: Infectious Diseases
Last Updated: July 14, 2022 |
The primary research focus of the Relman Lab is the human indigenous microbiota (microbiome), and in particular, the nature and mechanisms of variation in patterns of microbial diversity within the human body as a function of time (microbial succession), space (biogeography within the host landscape), and in response to perturbation, e.g., antibiotics (community robustness and resilience). One of the goals of this work is to define the role of the human microbiome in health and disease. We are particularly interested in measuring and understanding resilience in the human microbial ecosystem. Our work includes the human oral cavity, gut, and female reproductive tract, as well as an analysis of microbial diversity in marine mammals. This research integrates theory and methods from ecology, population biology, environmental microbiology, genomics and clinical medicine.
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David Lobell Earth Energy Env Sciences
Earth Energy Env Sciences
Last Updated: August 10, 2020 |
Food security; Agriculture; Data science; Remote Sensing |
David Kingsley Developmental Biology
Developmental Biology
Last Updated: December 01, 2022 |
Although the genomes of many organisms have now been sequenced, we still know relatively little about the specific DNA sequence changes that underlie important traits and diseases. My laboratory has developed an innovative combination of genetic and genomic approaches to identify the detailed molecular mechanisms that control key vertebrate traits. We use genetic crosses in mice, stickleback fish, and pluripotent stem cells to identify key chromosome regions controlling phenotypic traits. We use comparative genomics and gene expression analysis in different populations, species, and hybrids to identify particular genomic changes with these key regions. And we use transgenic and genome editing approaches to test the phenotypic effect of specific genomic changes, thus providing a direct functional link between DNA sequence changes and classic phenotypes. By combining genetics and genomics we have been able to identify the detailed molecular basis of major changes in skeletal structures, limb development, pigmentation, and neural functions across a range of populations and species. We are currently extending these approaches to genetic and genomic mapping of human traits and diseases using experiments with chimp and human stem cells. We are still a long way from knowing the genomic mechanisms that have made us human. However, we believe that molecular mechanisms contributing to human traits can now be studied, and that progress in this area will lead to important new insights into both human health and human disease. |
David Magnus Center for Biomedical Ethics, Med: Primary Care and Population Health
Center for Biomedical Ethics, Med: Primary Care and Population Health
Last Updated: November 11, 2021 |
The Stanford Center for Biomedical Ethics (SCBE) is an interdisciplinary hub for faculty who do research, teaching, and service on topics in bioethics and medical humanities. SCBE researchers have pioneered new approaches to studying the ethical issues presented by new technologies in biomedicine, including Artificial Intelligence, CRISPR and Gene Therapy, Stem Cell Research, Synthetic Biology, and the Human Brain Initiative. To benefit patients, SCBE has undertaken novel, ground-breaking research to improve clinical care, including end of life care, communication between patients and physicians, care for disabled patients, and organ transplantation processes. SCBE offers postdoctoral fellowships in Ethical, Legal, and Social Implications (ELSI) Research and Clinical Ethics. We currently have an opening for a postdoctoral fellow in Clinical Ethics. View more information here. |
David Magnus Center for Biomedical Ethics, Med: Primary Care and Population Health
Center for Biomedical Ethics, Med: Primary Care and Population Health
Last Updated: November 11, 2021 |
The Stanford Center for Biomedical Ethics (SCBE) is an interdisciplinary hub for faculty who do research, teaching, and service on topics in bioethics and medical humanities. SCBE researchers have pioneered new approaches to studying the ethical issues presented by new technologies in biomedicine, including Artificial Intelligence, CRISPR and Gene Therapy, Stem Cell Research, Synthetic Biology, and the Human Brain Initiative. To benefit patients, SCBE has undertaken novel, ground-breaking research to improve clinical care, including end of life care, communication between patients and physicians, care for disabled patients, and organ transplantation processes. SCBE offers postdoctoral fellowships in Ethical, Legal, and Social Implications (ELSI) Research and Clinical Ethics. We currently have an opening for a postdoctoral fellow in Clinical Ethics. View more information here. |
Danny Chou Pediatrics
Pediatrics
Last Updated: February 01, 2022 |
Our research program integrates concepts of chemical biology, protein engineering and structure biology to design new therapeutic leads and generate probes to study biological processes. A key focus of our lab is insulin, an essential hormone in our body to reduce blood glucose levels. We generate synthetic libraries of insulin analogs to select for chemical probes, and investigate natural insulin molecules (e.g. from the venom of fish-hunting cone snails!) to develop novel therapeutic candidates. We are especially interested in using chemical and enzymatic synthesis to create novel chemical entities with enhanced properties, and leverage the strong expertise of our collaborators to apply our skill sets in the fields of cancer biology, immunology and pain research. Our ultimate goal is to translate our discovery into therapeutic interventions in human diseases.
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