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Open Postdoctoral position, faculty mentor Lars Steinmetz

Important Info

Faculty Sponsor (Last, First Name): 
Steinmetz, Lars
Stanford Departments and Centers: 
Genetics
Postdoc Appointment Term: 
Initial contract of 2 years which can be extended up to 5 years.
Appointment Start Date: 
As soon as possible
How to Submit Application Materials: 

Email to Lars.Steinmetz[@]stanford.edu

Postdocs: Understanding Transcriptional Heterogeneity in Human Heart
We are currently seeking postdoctoral fellows join our DCM team who are working on understanding transcriptional heterogeneity in human heart with state-of-art sequencing technologies. Much progress has been made in understanding the genetics of cardiovascular diseases like Dilated Cardiomyopathy, but developing targeted therapies will require a better understanding of how genetics affects heart function. Due to technical limitations, it remains challenging to unravel the whole repertoire of different isoforms expressed in a population of cells. Our project therefore aims to map all full-length transcript isoforms in single heart cells. To overcome this, we propose to develop a method for the detection of full-length transcript isoforms at single cell resolution. In addition, we aim to add a read-out for CRISPR-mediated perturbations in order to obtain a systems analysis of the function of splice factors in single cells of the heart. We are looking for talented experimental biologists to lead the development of novel single-cell transcriptomics methods based on long-read sequencing, as well as experienced computational candidates to build on our existing pipelines for the analysis of our long-read data.
 
For more background on our work for DCM, you can read our recent publications: Zhu et al. Nature Communications, 2021 and Briganti et al. Cell Reports, 2020
 
About us:
The Steinmetz lab develops experimental approaches to read, edit and write entire genomes across scales. By applying these technologies, members of the lab aim at understanding the genetic basis of complex phenotypes, the mechanisms of transcription, and the molecular systems underpinning disease. Our lab operates in parallel to the Steinmetz lab at EMBL, Heidelberg in Germany. In addition to working with collaborators at Stanford and the Bay Area, you have the opportunity to network with our extensive network European collaborators as well. If you like working an a fun, international and interdisciplinary lab then get in touch! 
 

Required Qualifications: 
  • Candidates should have a Ph.D. in a relevant field with strong expertise in RNA biology and sequencing technologies.
  • Experience in cardiac biology and in cultivating or isolating heart cells will be a bonus but is not a requirement.
Required Application Materials: 
  • CV
  • A motivation letter

 

Stanford is an equal opportunity employer and all qualified applicants will receive consideration without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, or any other characteristic protected by law.