The Annes laboratory is interested in developing a regenerative therapy for diabetes. Over the past 5-10 years, our laboratory has identified, developed and optimized a variety of novel small molecules that potently induce human beta-cell growth, with the goal of increasing an individual’s insulin production capacity and reinstating normal glucose control. With these lead compounds in hand, the lab has turned toward addressing a major challenge in the regenerative medicine field: lineage-restricted (targeted) drug delivery.
Currently, the Annes lab is pioneering a variety of innovative strategies that enable the selective delivery of a regenerative therapeutic to beta-cells in order to make these compounds safe for human use. An example of our work on beta-cell selective drug delivery is PMID 30527998. The open post-doctoral position is to be filled by a candidate who is interested in (1) advancing a novel molecular strategy for beta-cell-targeted drug delivery, (2) expanding our understanding of normal beta-cell biology and (3) further elucidating diabetes pathogenesis from a beta-cell perspective. The overarching goal of this project is to advance the care of individuals suffering from diabetes.
- Doctoral degree
- The qualified candidate will work in a highly collaborative and rigorous research environment.
- Excellent interpersonal skills, scientific curiosity, motivation and ambition are critical attributes for the successful candidate.
- The primary research skill-sets needed are a strong background in molecular and cellular biology.
- Experience with animal research and physiology is highly preferred.
- A background in biochemistry (mass spectrometry and/or enzymology), pharmacology and/or chemistry are considered strengths.
- Small molecule work will be supported by a medicinal chemist (no synthetic chemistry skill required).
- A record of scientific productivity is helpful.
- An interest in being mentored for a career in academia as well as in mentoring younger trainees is desired.
- Curriculum vitae
- List of publications
- Contact information for two references
- A cover letter is recommended