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Open Postdoctoral position, faculty mentor James Ford

Important Info

Faculty Sponsor (Last, First Name): 
Ford, James
Department Name: 
Medicine-Oncology
Postdoc Appointment Term: 
1 year with annual renewal contingent on performance and funding.
Appointment Start Date: 
ASAP
How to Submit Application Materials: 

Please submit application materials directly to Dr. James Ford at jmf@stanford.edu.

We are seeking a postdoctoral scholar  in the lab of Dr. James Ford in the Division of Oncology at the Stanford School of Medicine. Our research focuses on understanding the role of genetic changes in cancer genes in the risk and development of common cancers and on manipulating DNA repair mechanisms for the prevention and treatment of cancer. Solid tumors often exhibit high levels of reactive oxygen species (ROS) resulting in oxidative damage and the generation of 8-oxoguanine (8-oxoG), a common source of mutations and DNA damage in the cell. ROS can be generated by multiple mechanisms including activating RAS mutations, exposure to chemical carcinogens and ionizing reagents, or as a by-product of metabolic processes in the cell.  ROS likely impacts the initiation of BRCA-mutated triple negative breast cancer (TNBC) through the accumulation of mutations in the cell.  Upregulating base excision repair (BER) pathways is a potentially viable approach to inhibiting tumorigenesis in BRCA-mutated individuals by reducing mutagenesis. We have identified small-molecule activators of BER and are exploring their mechanism of action and activity in cells and tumorogenesis models in mice.

Required Qualifications: 
  • The ideal candidate will have a PhD degree with no more than 2 years of postdoctoral experience
  • Have a background in DNA repair or cancer biology
  • Be self-motivated with a good publication record
  • Expected to lead their own projects as well as contribute to collaborative research efforts in a highly interactive environment
  • Have strong communication skills, both oral and written
  • Have experience in tissue culture, cellular assays and molecular biology techniques.
  • Have experience and a willingness to work with mice
Required Application Materials: 
  • A cover letter describing background, prior training, goals and reasons for interest in this position
  • Curriculum vitae listing relevant publications
  • Contact information for 3 references

 

Stanford is an equal opportunity employer and all qualified applicants will receive consideration without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, or any other characteristic protected by law.