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Open Postdoctoral position, faculty mentor James Ford

Important Info

Faculty Sponsor (Last, First Name): 
Ford, James
Stanford Departments and Centers: 
Med: Oncology
Postdoc Appointment Term: 
2 years with the option to extend an additional year
Appointment Start Date: 
March 1, 2022
How to Submit Application Materials: 

 Send letter or interest to Dr. James Ford at jmf@stanford.edu.

We are seeking a postdoctoral scholar in the lab of Dr. James Ford in the Division of Oncology at the Stanford School of Medicine. Our lab focuses on understanding the role of genetic changes in cancer genes involved in the risk and development of common cancers and on manipulating DNA repair mechanisms for the prevention and treatment of cancer. Solid tumors often exhibit high levels of reactive oxygen species (ROS) resulting in oxidative damage and the generation of 8-oxoguanine (8-oxoG), a common source of mutations and DNA damage in the cell.  ROS likely impacts the initiation of BRCA-mutated triple negative breast cancer through the accumulation of mutations in the cell.  Upregulating base excision repair (BER) pathways is a potentially viable approach to inhibiting tumorigenesis in BRCA-mutated individuals by reducing mutagenesis. We have identified small-molecule activators of BER and are exploring their mechanism of action and activity in cells and in tumorigenesis models in mice.  Other ongoing projects in our lab include elucidating the molecular determinants of resistance to PARP inhibitors and investigating novel drug combinatorial strategies as potential therapies for breast cancer.  The successful candidate will design a research program in collaboration with Dr. Ford and may choose to continue a current project or explore related directions. More information on the Ford lab can be found at https://med.stanford.edu/james-ford.html
 

Required Qualifications: 

• PhD degree (or expected within 3 months) with no more than 2 years of postdoctoral experience with a background in DNA repair or cancer biology
• Will lead their own projects as well as contribute to collaborative research efforts in a highly interactive environment
• Self-motivated with a good publication record and strong communication skills, both oral and written.
• Expected to write manuscripts and fellowship applications, as well as present data at both internal, national and international meetings.
• Should be well-versed in tissue culture, cellular assays and molecular biology techniques including viability assays, immunofluorescence staining, IHC, Western blot, nucleic acid purification, RT-qPCR, FACS, and modulation of gene expression by CRISPR/siRNA and transient/stable overexpression.
Experience and a willingness to work with mice is preferred.

Required Application Materials: 

Interested candidates should submit a letter of interest describing their background and prior training as well as their goals and reasons for interest in this position along with their CV listing relevant publications. 

 

Stanford is an equal opportunity employer and all qualified applicants will receive consideration without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, or any other characteristic protected by law.