Important Info
To apply, applicants should submit a cover letter, CV, and contact information of 3 references by email to Glaivy Batsuli, MD, Assistant Professor, Department of Pediatrics, Division of Hematology, Oncology, Stem Cell Transplantation, and Regenerative Medicine. Email: gbatsuli@stanford.edu. Incomplete applications will not be considered.
An opportunity for a postdoctoral fellow is available in the laboratory of Dr. Glaivy Batsuli in the Department of Pediatrics within the Division of Pediatric Hematology, Oncology, Stem Cell Transplantation, and Regenerative Medicine at Stanford University. The Batsuli Laboratory focuses on elucidating mechanisms of the adaptive immune response to blood coagulation factor proteins deficient in individuals with the inherited bleeding disorder hemophilia, namely factor VIII and factor IX. The goal of the laboratory’s work is to define the immune pathways that mediate the development of anti-factor antibodies in order to develop therapeutic strategies that evade or reverse the humoral immune response and promotes factor tolerance.
For this position, the postdoctoral applicant will conduct experiments evaluating the evolution of the antibody response against coagulation protein factor IX, which is missing or deficient in hemophilia B. Up to 10% of children with hemophilia B will develop antibodies against the factor IX protein after infusion. This treatment-related complication is uniquely associated with the development of allergic responses or life-threatening anaphylaxis with factor IX re-exposure, but the cause of this response is not known. To better understand the mechanisms driving allergic and anaphylactic responses with factor IX antibody development, the applicant will investigate the immune pathways that mediate antibody and allergy-mediated responses with factor IX exposure. This position will be partially supported by recent extramural grant funding.
This position is for a highly motivated individual with wet lab and animal (i.e., mouse) experience. This work will include components of blood coagulation, allergy/immunology, and molecular biology. Specific laboratory techniques to be performed include, but are not limited to, mice handling & procedures, tissue culture, ELISA, clotting assays, PCR, flow cytometry, FACS sorting, and RNA library preparation. There may also be an opportunity for translational research experiments utilizing banked patient samples.
As a member of the Batsuli Laboratory, the applicant will have the opportunity to lead interdisciplinary research projects and work in a highly collaborative environment committed to team science that will include other collaborating scientists, physicians, postdocs, technicians, and students. Additionally, the postdoc will be expected to prepare meeting abstracts, present their data at local and national conferences, submit grant applications, and prepare manuscripts for publication. Lastly, there will be opportunities to mentor and train students and other learners.
- This position is for an individual with a PhD in immunology or molecular biology. MD candidates with extensive laboratory experience in these areas will be considered.
- Experience in animal handling is a requirement of the position.
- Extensive experience or expertise with flow cytometry and flow analysis programs are required.
- Prior exposure to principles of allergic responses is desired but not required.
- Experience with RNA library preparation, RNA sequencing techniques, and bioinformatics analysis is welcomed.
- The candidate is expected to work independently, as part of a team, and collaboratively with other researchers.
- An individual who demonstrates self-initiative, motivation, flexibility, maturity, excellent communication, teamwork, a record of scientific productivity, data processing capabilities, written and oral presentation skills, and problem-solving skills are strongly desired.
- English proficiency is required.
- Cover letter including statement of interest, research experience, laboratory skills, and career goals
- Curriculum vitae (CV)
- Contact information for 3 recent references