The Spiekerkoetter laboratory is interested in pulmonary vascular diseases with an emphasis on the pathogenesis and treatment of pulmonary arterial hypertension, right heart failure, pulmonary arteriovenous malformations (AVM) in hereditary hemorrhagic telangiectasia (HHT), and the role of Bone Morphogenetic Protein Receptor 2 (BMPR2) signaling in these diseases. For the current project, in collaboration with the Metzger lab (Pediatric Cardiology), we aim to elucidate the cellular and molecular mechanisms that govern pulmonary AVM formation using 3-D deep tissue imaging, lineage tracing, and single-cell RNA sequencing techniques, and to identify and test compounds that can prevent or reverse AVM formation, utilizing high-throughput screening technology as well as novel computational analyses.
- We are looking for highly motivated postdoctoral candidates with a PhD, MD, or MD/PhD, and an established track record in vascular, cell, or developmental biology.
- The strongest candidates will have a working knowledge of mouse genetics, small animal handling and surgery, confocal microscopy, cell culture, expertise in a range of molecular and biochemical assays including RNA/DNA isolation and qRT-PCR.
- Excellent verbal and written communication skills are required
- Ability to work both independently and as part of a group
- For the right candidate this is an exciting opportunity to join a collaborative team of pulmonary vascular researchers, including Dr. Spiekerkoetter, an MD and Pulmonary and Critical Care Physician with a basic-translational research lab, as well as developmental biologists with an interest in the formation, maintenance, and repair of blood vessels in the lung.
- Curriculum vitae
- A short statement describing previous research experience and future goals
- Contact information for three referees