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My laboratory focuses on understanding how oncogenes cause cancer and investigating their role in maintaining cancer and identifying when shutting off an oncogene will result in reversal of cancer or "oncogene addiction". My lab is now funded through a NCI Oustanding Investigator Award and we are seeking new postdoctoral fellows. For a recent review of our work please see: The MYC oncogene — the grand orchestrator of cancer growth and immune evasion Nature Reviews Clinical Oncology volume 19, pages 23–36 (2022).
My laboratory studies the mechanisms of Oncogene Addiction: We are studying when and why inactivating individual oncogenes results in the regression of cancer. We employ mouse and human models. We are studying the role of tumor intrinsic programs (cellular senescence/self renewal, metabolism, programmed cell death) and host programs (immune oncology). For examples of our recent work, please see Casey et al, Science, 2016; Gouw et al, Cell Metabolism, 2019; Dhanasekaran et al eLife 2020 and Swaminathan et al Nat Comm 2020.
My laboratory develops Novel Diagnostics and Therapeutics: We are identifying novel small molecules, nanoparticles and proteins/peptides as therapeutics. We are studying novel imaging agents, nanoscale technologies and proteomics methods to identify and measure cancer. We are examining the role of Extracellular Vesicles, the Microbiome, Immune regulatory cytokines and cellular effects.
- MD, PhD or MD PHD training in relevant field of medicine, oncology, immunology, therapeutics, diagnostics, nanotechnology.
- A brief description of your interest in my lab
- Short and long term goals
- Three letters of reference