Contact: C. M. Weyand, MD, PhD E-mail: firstname.lastname@example.org
A postdoctoral research position is available at Stanford University in the laboratory of Dr. C. M. Weyand. The laboratory is engaged in investigating inflammation in medium and large blood vessels and in atherosclerosis. Collaborative projects involve investigators from the Stanford Institute for Immunology, Transplantation and Immunity, the Stanford Eye Institute, and the Stanford Cardiovascular Institute. Recent publications from the lab: 1. Immunoinhibitory checkpoint deficiency in medium and large vessel vasculitis. Zhang H, Watanabe R, Berry GJ, Vaglio A, Liao YJ, Warrington KJ, Goronzy JJ, Weyand CM. Proc Natl Acad Sci U S A. 2017 114:E970-E979 2. The microvascular niche instructs T cells in large vessel vasculitis via the VEGF-Jagged1-Notch pathway. Wen Z, Shen Y, Berry G, Shahram F, Li Y, Watanabe R, Liao YJ, Goronzy JJ, Weyand CM. Sci Transl Med 2017 9:pii: eaal3322 3. A mitochondrial checkpoint in autoimmune disease. Weyand CM, Goronzy JJ. Cell Metab 2018 28:185-18 We are particularly interested in how the innate and adaptive immune system malfunctions in blood vessels and in the atherosclerotic plaque lesion. We apply gene expression profiling as a discovery platform to define abnormalities in the immune system as well as in specified cell populations in the tissue niche. A series of functional assays have been developed to connect molecular abnormalities to clinical disease. The laboratory offers a broad spectrum of techniques, including flow cytometry and cell sorting, fluorescence and confocal microscopy, time-lapse microscopy, humanized mouse models, mammalian cell culture, and retroviral and lentiviral transduction systems to enable studies of molecular mechanisms. All projects have a strong translational component and involve patient-derived cells and specimens.
- Expertise in molecular biology techniques, immunology, histology techniques and in vitro assay systems.
- Experience in animal models and small animal surgery is desired but not required.
- Curriculum vitae
- A short statement describing previous research experience, future goals
- Contact information of three referees