Contact: C. M. Weyand, MD, PhD E-mail: email@example.com
A postdoctoral fellow position is available in Immunology at Stanford University in the laboratory of C. M. Weyand. The focus of the Weyand lab is to use humanized mouse models to discover and understand how autoimmune inflammation facilitates tissue and organ damage. We are particularly interested in metabolic control of tissue inflammation and how the mitochondria regulates autoimmunity, the cells’ metabolic program and the DNA repair machinery contribute to abnormal immune responses. Our disease models are rheumatoid arthritis, vasculitis and coronary artery disease. Recent publications from the lab: 1. N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation. Wen Z, Jin K, Shen Y, Yang Z, Li Y, Wu B, Tian L, Shoor S, Roche NE, Goronzy JJ, Weyand CM. Nat Immunol. 2019 20:313-325 2. Metabolic control of the scaffold protein TKS5 in tissue-invasive, proinflammatory T cells. Shen Y, Wen Z, Li Y, Matteson EL, Hong J, Goronzy JJ, Weyand CM. Nat Immunol. 2017 18:1025-103 3. Deficient activity of the nuclease MRE11A induces T cell aging and promotes arthritogenic effector functions in patients with rheumatoid arthritis. Li Y, Shen Y, Hohensinner P, Ju J, Wen Z, Goodman SB, Zhang H, Goronzy JJ, Weyand CM. Immunity. 2016 45:903-916 We use discovery approaches to pinpoint alterations that occur during immune-mediated inflammation and as cells enter the senescence program. We have established an array of functional assays and proceed with mechanistic investigation by altering the expression of candidate genes. All projects have a strong translational component in that most assay systems involve human cell populations.
- Recent PhD degree in immunology, cell biology, molecular biology, genetics or a related field.
- Experience with mouse models of human disease, cell signaling, molecular technologies would be an advantage.
- Curriculum vitae
- A short statement describing previous research experience, future goals
- Contact information of three referees