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The Petritsch lab broadly investigates underlying causes for the intra-tumoral heterogeneity and immune suppression in brain tumors (glioma) from a developmental neurobiology perspective. Our team is seeking applications from highly motivated trainees to participate in our research.
Candidates will work with mouse tumor models and leverage patient-derived specimen in complimentary alternate approaches, e.g. mechanistic investigations in human-derived patient samples, ex vivo tumor tissue slices, organoids, PDXs or tumor cell lines. The prospective candidate is expected to participate in one or more of the following projects.
1. Study brain cell lineage hierarchies in homeostasis and disease: Define mechanisms for cell fate determination in mammalian oligodendrocyte progenitor cells, identify and characterize molecular regulators of asymmetric cell division, investigate novel therapeutic targets to stimulate cell differentiation
2. Optimize molecular targeted therapy in glioma: define optimal dosing in novel preclinical models of glioma, study effects on cancer stem cells and neurocognition, and harnessing the tumor immune landscape in glioma to overcome therapy resistance
- A recent PhD or MD PhD
- Excellent communication skills
- Strong motivation to conduct original research
- Top skills in cell culture based experiments
- Fundamental understanding of cell and molecular biology are required
- Hands-on experience in sterile cell culturing
- Letter of Intent
- List of 3 referees