Please email the required application materials to Beatrice Ochoa at firstname.lastname@example.org.
Post Doc Position: Focus on Gene Modified Hematopoietic Stem Cell Dynamics and Transplantation Under Novel Non-Genotoxic Conditioning
Job Location: Czechowicz Laboratory | Biomedical Innovations Building, Stanford University, Stanford, CA.
The Czechowicz Laboratory has an opening for a creative, collaborative and motivated postdoctoral fellow with an interest in translational biomedical research with a focus on hematopoiesis, gene therapy and bone marrow transplantation (BMT). The successful candidate will join the Department of Pediatrics, Division of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine at Stanford University School of Medicine and will be given the opportunity to lead several exciting and innovative translational projects focusing initially specifically on Severe Combined Immunodeficiency (SCID), a rare disorder marked by the lack of infection-fighting immune cells with the potential to expand this work to many other diseases in the future.
Our laboratory has extensive experience in hematopoiesis, hematopoietic stem cells and hematopoietic cell transplantation, and in particular we have pioneered several non-genotoxic conditioning methods to make these transplantation procedures safer and more effective. These new conditioning approaches are now being translated with several clinical therapies in various stages of clinical development to enable safer donor BMT in patients. Further, with industry partners, we are also working on the development of ex vivo lentiviral gene therapies and other gene modification modalities. Our ultimate goal is to combine these treatments to enable ultra-safe and effective treatments using patients own cells.
The postdoc selected to join our laboratory will work to develop and continue projects in the lab that are at the interface of basic biomedical science and clinical research. The selected postdoc will work closely with the team to evaluate the safety and efficacy of new therapeutic modalities for combination treatment with a very nice and structured project that already has promising preliminary data. Additionally, the selected postdoc will work to elucidate underlying mechanisms that improve the engraftment of gene modified HSCs using mouse models and human patient samples, and have the ability to take this work in many unique directions.
Potential specific project aims include:
1. Evaluating hematopoietic stem and progenitor cell dynamics post-gene modification in SCID and study various innovative treatment modalities using mouse models and clinical samples
2. Increasing our understanding of native hematopoiesis of immunocompetent and immunocompromised bone marrow in order to potentially identify novel targets and develop new treatment strategies
3. Investigating the bone marrow microenvironment in settings of hematolymphoid dysfunction with a focus on improving transplantation of gene manipulated cells
The scope of our research employs a wide range for techniques including in vivo mouse disease models, flow cytometry, RNASeq/single cell transcriptome analysis, high-through put sequencing, DNA damage analysis, human clinical sample processing, humanized-mouse models, bone marrow transplantation, molecular cloning, tissue culture, proteomics, confocal microscopy and lentiviral transduction.
The postdoctoral fellow will have individualized mentorship tailored to his or her personal career and publications goals including regular meetings with Dr. Czechowicz to guarantee a successful fellowship. The fellow will also engage in a vibrant scientific discourse with the spectacular Stanford stem cell community and enjoy a positive and impact-oriented work environment. The fellow will also be expected to occasionally teach or mentor students and to help foster a productive learning environment, and additionally the fellow will have opportunities for clinical exposure if interested.
It is intended that the postdoctoral fellow will contribute to making important biomedical discoveries, and simultaneously grow through this position and develop the skills necessary to become a strong contributor to the advancement of science and/or medicine. This is an ideal role for fellows looking for subsequent opportunities in academia, industry or other associated business areas.
Postdoctoral fellow candidates must have a PhD, MD or MD/PhD. Candidates must have gained knowledge in hematopoiesis and/or cancer research, and be interested in bone marrow transplantation. Further, a prior background in gene manipulation techniques and/or immunology would be a significant plus. In order to be considered, candidates should have:
· demonstrated the ability to work independently
· shown initiative and prior research productivity
· attention to details
· strong motivation to explore new techniques and concepts
· collaborative team spirit
· excellent communication skills
· positive attitude
· adherence to highest ethical principles
Candidates with interest in translational biomedical research and prior experience in hematopoiesis, immunology, gene therapy/editing, cell therapy, DNA repair, and/or bone marrow transplantation are strongly encouraged to apply.
- An updated CV
- Complete contact information for three references
- Short cover letter describing past research experience, career goals and a statement of future research interest (1 page)