Ped: General Pediatrics
PRISM mentorsort ascending Research Interests

Thomas Robinson

Ped: General Pediatrics
Professor
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Ped: General Pediatrics

Last Updated: January 27, 2023

Stanford Solutions Science Lab.

The Stanford Solutions Science Lab designs solutions to improve health and well-being of children, families, and the planet.  Dr. Robinson originated the solution-oriented research paradigm. He is known for his pioneering obesity prevention and treatment research, including the concept of stealth interventions. His research applies social cognitive models of behavior change to behavioral, social, environmental and policy interventions for children and families in real world settings, making the results relevant for informing clinical and public health practice and policy. His research is largely experimental, conducting rigorous school-, family- and community-based randomized controlled trials. He studies obesity and disordered eating, nutrition, physical activity/inactivity and sedentary behavior, the effects of television and other screen time, adolescent smoking, aggressive behavior, consumerism, and behaviors to promote environmental sustainability. Rich longitudinal datasets of physical, physiological, psychological, behavioral, social, behavioral, and multi-omics measures are available from our many community-based obesity prevention and treatment trials in low-income and racial/ethnic minority populations of children and adolescents and their parents.

Stanford Screenomics Lab - Human Screenome Project.

People increasingly live their lives through smartphones. Our Stanford Screenomics app captures everything that people see and do on their smartphone screens – a record of digital life – by taking a screenshot every 5 seconds. The resulting sequence of screenshots, make up an individual’s screenome, an unique and dynamic sequence of exposures, thoughts, feelings, and actions. To date, we have collected more than 350 million screenshots from 6-12 months of phone use from national samples of about 500 hundred adults and adolescents and their parents. Opportunities available to study the screenome to understand digital media use and its impacts on health and behavior,  develop novel diagnostics and prognostics from the screenome, and deliver precision interventions to improve health and well being. An opportunity to help build this paradigm-disrupting new science.

Med: Prevention Research Cntr
PRISM mentorsort ascending Research Interests

Thomas Robinson

Med: Prevention Research Cntr
Professor
View in Stanford Profiles

Med: Prevention Research Cntr

Last Updated: January 27, 2023

Stanford Solutions Science Lab.

The Stanford Solutions Science Lab designs solutions to improve health and well-being of children, families, and the planet.  Dr. Robinson originated the solution-oriented research paradigm. He is known for his pioneering obesity prevention and treatment research, including the concept of stealth interventions. His research applies social cognitive models of behavior change to behavioral, social, environmental and policy interventions for children and families in real world settings, making the results relevant for informing clinical and public health practice and policy. His research is largely experimental, conducting rigorous school-, family- and community-based randomized controlled trials. He studies obesity and disordered eating, nutrition, physical activity/inactivity and sedentary behavior, the effects of television and other screen time, adolescent smoking, aggressive behavior, consumerism, and behaviors to promote environmental sustainability. Rich longitudinal datasets of physical, physiological, psychological, behavioral, social, behavioral, and multi-omics measures are available from our many community-based obesity prevention and treatment trials in low-income and racial/ethnic minority populations of children and adolescents and their parents.

Stanford Screenomics Lab - Human Screenome Project.

People increasingly live their lives through smartphones. Our Stanford Screenomics app captures everything that people see and do on their smartphone screens – a record of digital life – by taking a screenshot every 5 seconds. The resulting sequence of screenshots, make up an individual’s screenome, an unique and dynamic sequence of exposures, thoughts, feelings, and actions. To date, we have collected more than 350 million screenshots from 6-12 months of phone use from national samples of about 500 hundred adults and adolescents and their parents. Opportunities available to study the screenome to understand digital media use and its impacts on health and behavior,  develop novel diagnostics and prognostics from the screenome, and deliver precision interventions to improve health and well being. An opportunity to help build this paradigm-disrupting new science.

Shoa Clarke

Med: Prevention Research Cntr
Assistant Professor
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Med: Prevention Research Cntr

Last Updated: August 28, 2023

The Clarke Lab uses genomics, epidemiology, and data science to understand cardiovascular disease risk. Key areas of focus include: 1. Equitable development and applications of polygenic risk scores

2. Novel phenotyping using electronic health records, wearables, and/or medical imaging

3.  Artificial intelligence applications to medical imaging

4. Studying nataionl biobanks (Million Veteran Program, UK Biobank, All of Us)

 

  • Cardiovascular Disease Prevention Training Program
Epidemiology and Population Health
PRISM mentorsort ascending Research Interests

Thomas Robinson

Epidemiology and Population Health
Professor
View in Stanford Profiles

Epidemiology and Population Health

Last Updated: January 27, 2023

Stanford Solutions Science Lab.

The Stanford Solutions Science Lab designs solutions to improve health and well-being of children, families, and the planet.  Dr. Robinson originated the solution-oriented research paradigm. He is known for his pioneering obesity prevention and treatment research, including the concept of stealth interventions. His research applies social cognitive models of behavior change to behavioral, social, environmental and policy interventions for children and families in real world settings, making the results relevant for informing clinical and public health practice and policy. His research is largely experimental, conducting rigorous school-, family- and community-based randomized controlled trials. He studies obesity and disordered eating, nutrition, physical activity/inactivity and sedentary behavior, the effects of television and other screen time, adolescent smoking, aggressive behavior, consumerism, and behaviors to promote environmental sustainability. Rich longitudinal datasets of physical, physiological, psychological, behavioral, social, behavioral, and multi-omics measures are available from our many community-based obesity prevention and treatment trials in low-income and racial/ethnic minority populations of children and adolescents and their parents.

Stanford Screenomics Lab - Human Screenome Project.

People increasingly live their lives through smartphones. Our Stanford Screenomics app captures everything that people see and do on their smartphone screens – a record of digital life – by taking a screenshot every 5 seconds. The resulting sequence of screenshots, make up an individual’s screenome, an unique and dynamic sequence of exposures, thoughts, feelings, and actions. To date, we have collected more than 350 million screenshots from 6-12 months of phone use from national samples of about 500 hundred adults and adolescents and their parents. Opportunities available to study the screenome to understand digital media use and its impacts on health and behavior,  develop novel diagnostics and prognostics from the screenome, and deliver precision interventions to improve health and well being. An opportunity to help build this paradigm-disrupting new science.

SUZAN CARMICHAEL

Epidemiology and Population Health
PROFESSOR
View in Stanford Profiles

Epidemiology and Population Health

Last Updated: January 29, 2023

Our team is committed to finding ways to improve maternal and infant health outcomes and equity by leading research that identifies effective leverage points for change, from upstream 'macro' social and structural factors, to downstream 'micro' clinical factors through a collaborative research approach that integrates epidemiologic approaches with community engagement and systems thinking.

Disparities are prominent in maternal and infant health, so a lot of our work is centered on equity.  Focusing on highest-risk groups will improve health for everyone.

Much of our current research focuses on severe maternal morbidity (SMM). SMM encompasses adverse conditions that put pregnant people at risk of short and long-term consequences related to labor and delivery, including death.

We also study other important perinatal outcomes, including stillbirth, preterm birth, structural congenital malformations and other maternal morbidities.  We are interested in these outcomes individually, as well as in how they are connected to each other -- from a mechanistic standpoint (ie, do they share the same causes), and a lifecourse perspective (eg, how does an adverse newborn outcome affect the mom's postpartum health, and vice versa).

Dr. Carmichael's training is in perinatal and nutritional epidemiology.  She deeply appreciates her multi-disciplinary colleagues who make this work more meaningful by bringing their own varied perspectives and lived experiences, and their expertise in clinical care, qualitative and mixed methods, community engagement, and state-of-the-art epidemiologic approaches and biostatistical methods.

Cardiovascular Institute
PRISM mentorsort ascending Research Interests

Thomas Robinson

Cardiovascular Institute
Professor
View in Stanford Profiles

Cardiovascular Institute

Last Updated: January 27, 2023

Stanford Solutions Science Lab.

The Stanford Solutions Science Lab designs solutions to improve health and well-being of children, families, and the planet.  Dr. Robinson originated the solution-oriented research paradigm. He is known for his pioneering obesity prevention and treatment research, including the concept of stealth interventions. His research applies social cognitive models of behavior change to behavioral, social, environmental and policy interventions for children and families in real world settings, making the results relevant for informing clinical and public health practice and policy. His research is largely experimental, conducting rigorous school-, family- and community-based randomized controlled trials. He studies obesity and disordered eating, nutrition, physical activity/inactivity and sedentary behavior, the effects of television and other screen time, adolescent smoking, aggressive behavior, consumerism, and behaviors to promote environmental sustainability. Rich longitudinal datasets of physical, physiological, psychological, behavioral, social, behavioral, and multi-omics measures are available from our many community-based obesity prevention and treatment trials in low-income and racial/ethnic minority populations of children and adolescents and their parents.

Stanford Screenomics Lab - Human Screenome Project.

People increasingly live their lives through smartphones. Our Stanford Screenomics app captures everything that people see and do on their smartphone screens – a record of digital life – by taking a screenshot every 5 seconds. The resulting sequence of screenshots, make up an individual’s screenome, an unique and dynamic sequence of exposures, thoughts, feelings, and actions. To date, we have collected more than 350 million screenshots from 6-12 months of phone use from national samples of about 500 hundred adults and adolescents and their parents. Opportunities available to study the screenome to understand digital media use and its impacts on health and behavior,  develop novel diagnostics and prognostics from the screenome, and deliver precision interventions to improve health and well being. An opportunity to help build this paradigm-disrupting new science.

Sushma Reddy

Cardiovascular Institute
Associate Professor of Pediatrics
View in Stanford Profiles

Cardiovascular Institute

Last Updated: September 05, 2023

My laboratory's overall goal is to (i) understand the mechanisms of right heart failure in children and adults with congenital heart disease and (ii) to develop biomarkers as a plasma signature of myocardial events to better understand the mechanisms of heart failure, improve monitoring of disease progression, early detection of heart failure and risk-stratification.

We have focused on tetralogy of Fallot population and single ventricle heart disease. As the survival continues to improve, so also has the incidence of heart failure. However, the underlying cellular mechanisms of heart failure are poorly understood as a result of which no targeted therapy is available. Since it is not possible to obtain heart muscle biopsies routinely on patients, we have taken a novel strategy of using Multi-Omics to better understand disease mechanisms and to follow patients over time comparing their Omics signature to themselves thereby personalizing their care. The goal is to create a targeted biomarker panel for clinical utility to be used in conjunction with imaging data to improve overall prediction of risk. Based on our work to date, we are also interested in understanding myocardial mitochondrial and vascular dysfunction as these have the potential to serve as novel therapeutic targets.

Lab website is in creation. Link will be updated when it is ready.

 

  • Training in Myocardial Biology at Stanford (TIMBS)
Stanford Cancer Center
PRISM mentorsort ascending Research Interests

Thomas Robinson

Stanford Cancer Center
Professor
View in Stanford Profiles

Stanford Cancer Center

Last Updated: January 27, 2023

Stanford Solutions Science Lab.

The Stanford Solutions Science Lab designs solutions to improve health and well-being of children, families, and the planet.  Dr. Robinson originated the solution-oriented research paradigm. He is known for his pioneering obesity prevention and treatment research, including the concept of stealth interventions. His research applies social cognitive models of behavior change to behavioral, social, environmental and policy interventions for children and families in real world settings, making the results relevant for informing clinical and public health practice and policy. His research is largely experimental, conducting rigorous school-, family- and community-based randomized controlled trials. He studies obesity and disordered eating, nutrition, physical activity/inactivity and sedentary behavior, the effects of television and other screen time, adolescent smoking, aggressive behavior, consumerism, and behaviors to promote environmental sustainability. Rich longitudinal datasets of physical, physiological, psychological, behavioral, social, behavioral, and multi-omics measures are available from our many community-based obesity prevention and treatment trials in low-income and racial/ethnic minority populations of children and adolescents and their parents.

Stanford Screenomics Lab - Human Screenome Project.

People increasingly live their lives through smartphones. Our Stanford Screenomics app captures everything that people see and do on their smartphone screens – a record of digital life – by taking a screenshot every 5 seconds. The resulting sequence of screenshots, make up an individual’s screenome, an unique and dynamic sequence of exposures, thoughts, feelings, and actions. To date, we have collected more than 350 million screenshots from 6-12 months of phone use from national samples of about 500 hundred adults and adolescents and their parents. Opportunities available to study the screenome to understand digital media use and its impacts on health and behavior,  develop novel diagnostics and prognostics from the screenome, and deliver precision interventions to improve health and well being. An opportunity to help build this paradigm-disrupting new science.

Woods Institute
PRISM mentorsort ascending Research Interests

Thomas Robinson

Woods Institute
Professor
View in Stanford Profiles

Woods Institute

Last Updated: January 27, 2023

Stanford Solutions Science Lab.

The Stanford Solutions Science Lab designs solutions to improve health and well-being of children, families, and the planet.  Dr. Robinson originated the solution-oriented research paradigm. He is known for his pioneering obesity prevention and treatment research, including the concept of stealth interventions. His research applies social cognitive models of behavior change to behavioral, social, environmental and policy interventions for children and families in real world settings, making the results relevant for informing clinical and public health practice and policy. His research is largely experimental, conducting rigorous school-, family- and community-based randomized controlled trials. He studies obesity and disordered eating, nutrition, physical activity/inactivity and sedentary behavior, the effects of television and other screen time, adolescent smoking, aggressive behavior, consumerism, and behaviors to promote environmental sustainability. Rich longitudinal datasets of physical, physiological, psychological, behavioral, social, behavioral, and multi-omics measures are available from our many community-based obesity prevention and treatment trials in low-income and racial/ethnic minority populations of children and adolescents and their parents.

Stanford Screenomics Lab - Human Screenome Project.

People increasingly live their lives through smartphones. Our Stanford Screenomics app captures everything that people see and do on their smartphone screens – a record of digital life – by taking a screenshot every 5 seconds. The resulting sequence of screenshots, make up an individual’s screenome, an unique and dynamic sequence of exposures, thoughts, feelings, and actions. To date, we have collected more than 350 million screenshots from 6-12 months of phone use from national samples of about 500 hundred adults and adolescents and their parents. Opportunities available to study the screenome to understand digital media use and its impacts on health and behavior,  develop novel diagnostics and prognostics from the screenome, and deliver precision interventions to improve health and well being. An opportunity to help build this paradigm-disrupting new science.

HumanCentered Artificial Inte
PRISM mentorsort ascending Research Interests

Thomas Robinson

HumanCentered Artificial Inte
Professor
View in Stanford Profiles

HumanCentered Artificial Inte

Last Updated: January 27, 2023

Stanford Solutions Science Lab.

The Stanford Solutions Science Lab designs solutions to improve health and well-being of children, families, and the planet.  Dr. Robinson originated the solution-oriented research paradigm. He is known for his pioneering obesity prevention and treatment research, including the concept of stealth interventions. His research applies social cognitive models of behavior change to behavioral, social, environmental and policy interventions for children and families in real world settings, making the results relevant for informing clinical and public health practice and policy. His research is largely experimental, conducting rigorous school-, family- and community-based randomized controlled trials. He studies obesity and disordered eating, nutrition, physical activity/inactivity and sedentary behavior, the effects of television and other screen time, adolescent smoking, aggressive behavior, consumerism, and behaviors to promote environmental sustainability. Rich longitudinal datasets of physical, physiological, psychological, behavioral, social, behavioral, and multi-omics measures are available from our many community-based obesity prevention and treatment trials in low-income and racial/ethnic minority populations of children and adolescents and their parents.

Stanford Screenomics Lab - Human Screenome Project.

People increasingly live their lives through smartphones. Our Stanford Screenomics app captures everything that people see and do on their smartphone screens – a record of digital life – by taking a screenshot every 5 seconds. The resulting sequence of screenshots, make up an individual’s screenome, an unique and dynamic sequence of exposures, thoughts, feelings, and actions. To date, we have collected more than 350 million screenshots from 6-12 months of phone use from national samples of about 500 hundred adults and adolescents and their parents. Opportunities available to study the screenome to understand digital media use and its impacts on health and behavior,  develop novel diagnostics and prognostics from the screenome, and deliver precision interventions to improve health and well being. An opportunity to help build this paradigm-disrupting new science.

Surg: Otolaryngology
PRISM mentorsort ascending Research Interests

Teresa Nicolson

Surg: Otolaryngology
Professor
View in Stanford Profiles

Surg: Otolaryngology

Last Updated: November 29, 2021

Our research focuses on genetic forms of hearing loss and vestibular dysfunction. As many features of the auditory/vestibular system are highly conserved among vertebrates, we use zebrafish as our animal model and have identified over a dozen genes that are required for hearing and balance. Our studies have yielded important insights into the molecular basis of sensory hair-cell function, especially with regard to mechanotransduction and synaptic transmission. To understand the function of deafness genes and delve deeper into the underlying biology, our lab uses a wide range of methods to analyze mutant phenotypes including live cell imaging, physiological experiments, CRISPR gene editing, transcriptomic methods, and auditory/vestibular behavioral analyses. Department URL: https://med.stanford.edu/ohns.html

  • Clinician-scientist training program in otolaryngology
Radiation Oncology
PRISM mentorsort ascending Research Interests

Ted Graves

Radiation Oncology
Associate Professor
View in Stanford Profiles

Radiation Oncology

Last Updated: July 13, 2022

My laboratory is focused on development and application of molecular imaging techniques towards understanding radiation and cancer biology and improving treatment of human disease. Using modalities including positron emission tomography (PET), computed tomography (CT), fluorescence imaging, bioluminescence imaging, and small animal conformal radiotherapy, we are investigating the molecular and physiologic factors that determine tumor response to therapy. In addition, we are applying this knowledge towards the development of combination therapies that improve tumor response and minimize normal tissue toxicity. We are a multi-disciplinary group with expertise in engineering, biology, chemistry, medicine, and computer science.

  • Cancer Etiology, Prevention, Detection and Diagnosis
  • Postdoctoral Training in the Radiation Sciences
  • Stanford Cancer Imaging Training (SCIT) Program
  • Stanford Molecular Imaging Scholars (SMIS)
Radiology
PRISM mentorsort ascending Research Interests

Tanya Stoyanova

Radiology
Assistant Professor
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Radiology

Last Updated: July 13, 2022

Stoyanova lab is interested in understanding fundamental molecular mechanisms underlying the development of epithelial cancers and their utility as biomarkers and therapeutic targets. Currently, the major focus of our group is in prostate cancer. We are also interested in breast and neuroendocrine cancers. The ultimate goals of the laboratory are to: 1) improve the stratification of indolent from aggressive prostate cancer and 2) guide the development of novel and effective therapeutic strategies for metastatic cancers.

Sindy Tang

Radiology
Associate Professor
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Radiology

Last Updated: January 27, 2024

From finger prick tests for blood glucose monitoring to industrial-scale drug screening in pharmaceutical companies, the ability to extract information from scarce volumes of samples quickly and cheaply is key to effective disease management and drug discovery. To this end, microfluidics offers major advantages over conventional liquid handling due to drastic reduction in reagent volume and the precise control of single cells, microtissues, and their microenvironments. The micro-nano-bio lab under the direction of Dr. Sindy Tang aims to develop innovative micro and nanoscale devices that harness mass transport phenomena to enable precise manipulation, measurement, and recapitulation of biological systems, in order to understand the "rules of life" and accelerate precision medicine and material design for a future with better health and environmental sustainability. Our approach involves building new tools to probe biological systems (from single cells to microtissues), and engineering smart materials, synthetic cells & tissues with properties that mimic some of the amazing properties biological systems have. Current research projects include:

 

  • Understanding and accelerating the diagnosis of allergic diseases
  • Biomechanics of single cell wound resilience
  • Tools for advancing cancer research
  • Bottom-up construction of biological systems

Sindy Tang

Radiology
Associate Professor
View in Stanford Profiles

Radiology

Last Updated: August 24, 2023

Postdoctoral Research Fellow – Cell biology & microfluidics, UCSF & Stanford

A joint postdoc position between the labs of Wallace Marshall (UCSF) and Sindy Tang (Stanford) is immediately available in the area of single-cell wound healing. The broad question we aim to answer is how the single-celled ciliate Stentor can heal drastic wounds. We are looking for a candidate with a background in cell biology or related fields. This position will allow ample opportunities to learn new techniques including microfluidics for single-cell manipulation and mathematical modeling. Application For questions or applications (see below), please feel free to reach out to Prof. Wallace Marshall (wallace.ucsf@gmail.com) or Prof. Sindy Tang (sindy@stanford.edu). To apply, please include a CV (with a publication list) and some detail about your background and interest in the project. Project description: Biomechanical mechanisms conferring wound resilience in single-celled organisms Stentor coeruleus is a large, single-celled ciliate that has remarkable wound healing and regenerative capacity (see Slabodnick et al., Current Bio, 2014 https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.10...). It is found in environments that can be subject to high mechanical stresses due to natural flows or predation. The overall goal of this project is to investigate how this organism employs both mechanical and biochemical mechanisms upstream of wounding for wound prevention, as well as downstream of wounding for robust healing from wounds (https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-021-00970-0).

We have sequenced the Stentor genome, and developed tools for molecular manipulation of Stentor gene expression to pave the way to a molecular understanding of Stentor wound response.   This project involves conceptualization of a novel chemical screen to test the role of the cytoskeleton in conferring wound resistance to the cell, and the role of large-scale mechanical force generation in complementing biochemical healing modes to close wounds of increasing severity.

Some questions we ask are: how does Stentor cell mechanics give rise to wound resistance? How do cells respond to shear or other types of stresses? What molecular pathways are important in Stentor wound healing, and are they the same as in other eukaryotes? The project combines cell biology, microfluidics for precise wounding (see Blauch et al., PNAS 2017 https://www.pnas.org/doi/abs/10.1073/pnas.1705059114), and mechanobiology modeling.

Required Qualifications: Desired skills for this project include: • Cell biology • Chemical screen • RNAi and genetic transformation • Past experience with Stentor, other ciliates, or manipulation (e.g., microinjection) of large cells or embryos such as Drosophila • Mathematical modelling of cellular processes Candidates proficient in certain skills outlined above will have opportunities to receive training in complementary skill sets.

Required Application Materials: Your CV with a publication list, and some detail about your background and interest in the project.

Shreyas Vasanawala

Radiology
Professor
View in Stanford Profiles

Radiology

Last Updated: February 23, 2024

We are seeking a talented individual for a research associate position in our multidisciplinary team. Our advanced pediatric MRI research program spans across novel developments in hardware, pulse sequences, machine learning algorithms, image reconstruction methods, and image analysis techniques, all with an integrated clinical translational component. Efforts bridge across multiple departments on the Stanford University campus and UC Berkeley, as well as with Silicon Valley companies. The position offers the opportunity to work with multiple faculty, post-doctoral scholars, graduate students, and undergraduates. Responsibilities include developing novel techniques, contributing to grant proposals, writing and submitting manuscripts, and developing intellectual property.

Psyc: Child Psychiatry
PRISM mentorsort ascending Research Interests

Tamar Green

Psyc: Child Psychiatry
Assistant Professor
View in Stanford Profiles

Psyc: Child Psychiatry

Last Updated: February 21, 2024

1. Genetic of neuropsychiatric condisions: Concentrating on isolating genetic factors that drive neurodevelopmental disorders like ASD and ADHD. The focus is on unraveling the complex genetic architecture using monogenic genetic conditions, this approach called a genetic first approach in psychiatry.

2. Ras Pathway's Impact on Neurodevelopment: Probing the Ras/MAPK pathway's role in developmental brain disorders, assessing how mutations lead to clinical manifestations in disorders such as Noonan syndrome. The goal is to clarify the pathway's influence on neural circuitry and identify actionable targets for therapy.

3. Integrative Neuroimaging for Clinical Outcomes: Leveraging advanced neuroimaging to quantify brain changes and connectivity patterns in genetic conditions. This rigorous analysis aims to establish neuroimaging as a quantitative tool for evaluating the efficacy of novel treatments in clinical trials. Emphasizing the development of brain-based metrics as a means to validate and refine treatment strategies, with the ultimate objective of personalized medicine.

 

  • Research Training for Child Psychiatry and Neurodevelopment
Biochemistry
PRISM mentorsort ascending Research Interests

Suzanne Pfeffer

Biochemistry
Professor
View in Stanford Profiles

Biochemistry

Last Updated: August 15, 2023

Our lab seeks to understand the molecular basis of inherited Parkinson's Disease.  Activating mutations in the LRRK2 kinase cause Parkinson's , and the major substrates of LRRK2 kinase are a subset of proteins called Rab GTPases.  Together with our collaborators, we have discovered that phosphorylation of Rab proteins completely changes the partner proteins with which they interact and leads to a blockade in the formation of critical signaling structures called primary cilia.  We are using biochemical, cell biological and genome-wide approaches to study the molecular cell biology of Parkinson's Disease by focusing on the consequences of Rab GTPase phosphorylation.  Our work includes single molecule biochemical experiments to undertstand the kinase and its corresponding phosphatase--how they are recruited to membranes and activated.  We also study LRRK2-mediated loss of cilia in specific neuronal cell types and astrocytes in both mouse and human brains.  We are using state of the art microscopic tools to understand why cilia are lost and how this leads to Parkinson's disease.

Neurosurgery
PRISM mentorsort ascending Research Interests

Suzanne Tharin

Neurosurgery
Assistant Professor
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Neurosurgery

Last Updated: February 23, 2024

We study the roles of microRNAs in cortical projection neuron development, with an emphasis on corticospinal motor neurons. We have identified a group of mircoRNAs specifically enriched in corticospinal motor neurons during their development and are investigating their functions in cortical progenitors in vitro and in vivo, as well as in ES cells.

Pediatrics
PRISM mentorsort ascending Research Interests

SUZAN CARMICHAEL

Pediatrics
PROFESSOR
View in Stanford Profiles

Pediatrics

Last Updated: January 29, 2023

Our team is committed to finding ways to improve maternal and infant health outcomes and equity by leading research that identifies effective leverage points for change, from upstream 'macro' social and structural factors, to downstream 'micro' clinical factors through a collaborative research approach that integrates epidemiologic approaches with community engagement and systems thinking.

Disparities are prominent in maternal and infant health, so a lot of our work is centered on equity.  Focusing on highest-risk groups will improve health for everyone.

Much of our current research focuses on severe maternal morbidity (SMM). SMM encompasses adverse conditions that put pregnant people at risk of short and long-term consequences related to labor and delivery, including death.

We also study other important perinatal outcomes, including stillbirth, preterm birth, structural congenital malformations and other maternal morbidities.  We are interested in these outcomes individually, as well as in how they are connected to each other -- from a mechanistic standpoint (ie, do they share the same causes), and a lifecourse perspective (eg, how does an adverse newborn outcome affect the mom's postpartum health, and vice versa).

Dr. Carmichael's training is in perinatal and nutritional epidemiology.  She deeply appreciates her multi-disciplinary colleagues who make this work more meaningful by bringing their own varied perspectives and lived experiences, and their expertise in clinical care, qualitative and mixed methods, community engagement, and state-of-the-art epidemiologic approaches and biostatistical methods.

Suzan Carmichael

Pediatrics
Professor
View in Stanford Profiles

Pediatrics

Last Updated: July 13, 2022

Dr. Carmichael is a perinatal and nutritional epidemiologist and Professor of Pediatrics and Obstetrics and Gynecology at the Stanford University School of Medicine. Her research focuses on finding ways to improve maternal and infant health. Exposure themes include nutrition, social context, care, environmental contaminants and genetics. Outcome themes include severe maternal morbidity, stillbirth, birth defects, and preterm delivery. She is particularly interested in understanding the intersectionality of these varied types of exposures and outcomes and how they interact to impact health and health disparities, for the mother-baby dyad, in domestic as well as global health settings. She currently (mid 2020) has an opening in her lab for a post-doc focused on maternal health.

Sushma Reddy

Pediatrics
Associate Professor of Pediatrics
View in Stanford Profiles

Pediatrics

Last Updated: September 05, 2023

My laboratory's overall goal is to (i) understand the mechanisms of right heart failure in children and adults with congenital heart disease and (ii) to develop biomarkers as a plasma signature of myocardial events to better understand the mechanisms of heart failure, improve monitoring of disease progression, early detection of heart failure and risk-stratification.

We have focused on tetralogy of Fallot population and single ventricle heart disease. As the survival continues to improve, so also has the incidence of heart failure. However, the underlying cellular mechanisms of heart failure are poorly understood as a result of which no targeted therapy is available. Since it is not possible to obtain heart muscle biopsies routinely on patients, we have taken a novel strategy of using Multi-Omics to better understand disease mechanisms and to follow patients over time comparing their Omics signature to themselves thereby personalizing their care. The goal is to create a targeted biomarker panel for clinical utility to be used in conjunction with imaging data to improve overall prediction of risk. Based on our work to date, we are also interested in understanding myocardial mitochondrial and vascular dysfunction as these have the potential to serve as novel therapeutic targets.

Lab website is in creation. Link will be updated when it is ready.

 

  • Training in Myocardial Biology at Stanford (TIMBS)

Sushma Reddy

Pediatrics
Associate Professor of Pediatrics
View in Stanford Profiles

Pediatrics

Last Updated: January 27, 2023

Current Research and Scholarly Interests My laboratory's overall goal is to (i) understand the mechanisms of right heart failure in children and adults with congenital heart disease and (ii) to develop biomarkers as a plasma signature of myocardial events to better understand the mechanisms of heart failure, improve monitoring of disease progression, early detection of heart failure and risk-stratification.

We have focused on tetralogy of Fallot population and single ventricle heart disease. As the survival continues to improve, so also has the incidence of heart failure. However, the underlying cellular mechanisms of heart failure are poorly understood as a result of which no targeted therapy is available. Since it is not possible to obtain heart muscle biopsies routinely on patients, we have taken a novel strategy of using Multi-Omics to better understand disease mechanisms and to follow patients over time comparing their Omics signature to themselves thereby personalizing their care. The goal is to create a targeted biomarker panel for clinical utility to be used in conjunction with imaging data to improve overall prediction of risk. Based on our work to date, we are also interested in understanding myocardial mitochondrial and vascular dysfunction as these have the potential to serve as novel therapeutic targets.

Maternal Fetal Medicine and Obstetrics
PRISM mentorsort ascending Research Interests

SUZAN CARMICHAEL

Maternal Fetal Medicine and Obstetrics
PROFESSOR
View in Stanford Profiles

Maternal Fetal Medicine and Obstetrics

Last Updated: January 29, 2023

Our team is committed to finding ways to improve maternal and infant health outcomes and equity by leading research that identifies effective leverage points for change, from upstream 'macro' social and structural factors, to downstream 'micro' clinical factors through a collaborative research approach that integrates epidemiologic approaches with community engagement and systems thinking.

Disparities are prominent in maternal and infant health, so a lot of our work is centered on equity.  Focusing on highest-risk groups will improve health for everyone.

Much of our current research focuses on severe maternal morbidity (SMM). SMM encompasses adverse conditions that put pregnant people at risk of short and long-term consequences related to labor and delivery, including death.

We also study other important perinatal outcomes, including stillbirth, preterm birth, structural congenital malformations and other maternal morbidities.  We are interested in these outcomes individually, as well as in how they are connected to each other -- from a mechanistic standpoint (ie, do they share the same causes), and a lifecourse perspective (eg, how does an adverse newborn outcome affect the mom's postpartum health, and vice versa).

Dr. Carmichael's training is in perinatal and nutritional epidemiology.  She deeply appreciates her multi-disciplinary colleagues who make this work more meaningful by bringing their own varied perspectives and lived experiences, and their expertise in clinical care, qualitative and mixed methods, community engagement, and state-of-the-art epidemiologic approaches and biostatistical methods.

Suzan Carmichael

Maternal Fetal Medicine and Obstetrics
Professor
View in Stanford Profiles

Maternal Fetal Medicine and Obstetrics

Last Updated: July 13, 2022

Dr. Carmichael is a perinatal and nutritional epidemiologist and Professor of Pediatrics and Obstetrics and Gynecology at the Stanford University School of Medicine. Her research focuses on finding ways to improve maternal and infant health. Exposure themes include nutrition, social context, care, environmental contaminants and genetics. Outcome themes include severe maternal morbidity, stillbirth, birth defects, and preterm delivery. She is particularly interested in understanding the intersectionality of these varied types of exposures and outcomes and how they interact to impact health and health disparities, for the mother-baby dyad, in domestic as well as global health settings. She currently (mid 2020) has an opening in her lab for a post-doc focused on maternal health.

Ped: Cardiology
PRISM mentorsort ascending Research Interests

Sushma Reddy

Ped: Cardiology
Associate Professor of Pediatrics
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Ped: Cardiology

Last Updated: September 05, 2023

My laboratory's overall goal is to (i) understand the mechanisms of right heart failure in children and adults with congenital heart disease and (ii) to develop biomarkers as a plasma signature of myocardial events to better understand the mechanisms of heart failure, improve monitoring of disease progression, early detection of heart failure and risk-stratification.

We have focused on tetralogy of Fallot population and single ventricle heart disease. As the survival continues to improve, so also has the incidence of heart failure. However, the underlying cellular mechanisms of heart failure are poorly understood as a result of which no targeted therapy is available. Since it is not possible to obtain heart muscle biopsies routinely on patients, we have taken a novel strategy of using Multi-Omics to better understand disease mechanisms and to follow patients over time comparing their Omics signature to themselves thereby personalizing their care. The goal is to create a targeted biomarker panel for clinical utility to be used in conjunction with imaging data to improve overall prediction of risk. Based on our work to date, we are also interested in understanding myocardial mitochondrial and vascular dysfunction as these have the potential to serve as novel therapeutic targets.

Lab website is in creation. Link will be updated when it is ready.

 

  • Training in Myocardial Biology at Stanford (TIMBS)
Physics
PRISM mentorsort ascending Research Interests

Susan Clark

Physics
Assistant Professor
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Physics

Last Updated: August 15, 2023

Susan is broadly interested in astrophysical magnetism and the physics of the interstellar medium (ISM), from diffuse gas to dense, star-forming regions. Susan’s research tackles open questions like the structure of the Milky Way’s magnetic field, the nature of interstellar turbulence and the multi-phase ISM, and the role of magnetism in star formation. These big questions demand multiwavelength observations and new data analysis techniques. Susan and her group decipher the magnetic ISM using a combination of theory and observation. Data-wise, the group uses a wide range of tracers including gas line emission and absorption, polarized dust and synchrotron emission, starlight polarization, Zeeman splitting, and Faraday rotation. Susan is involved in a number of current and future telescope projects, and leads several efforts focused on Galactic science with sensitive measurements of millimeter-wavelength emission made by cosmic microwave background experiments like the Atacama Cosmology Telescope (ACT) and the Simons Observatory (SO).

Susan Clark

Physics
Assistant Professor
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Physics

Last Updated: October 18, 2021

Susan is broadly interested in astrophysical magnetism and the physics of the interstellar medium (ISM), from diffuse gas to dense, star-forming regions. Susan’s research tackles open questions like the structure of the Milky Way’s magnetic field, the nature of interstellar turbulence, and the role of magnetism in star formation. These big questions demand multiwavelength observations and new data analysis techniques. Susan is particularly interested in deciphering the magnetic ISM using sensitive measurements of synchrotron and polarized dust emission made by cosmic microwave background experiments like the Atacama Cosmology Telescope (ACT) and the Simons Observatory (SO).

Steven Allen

Physics
Professor
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Physics

Last Updated: February 23, 2024

Steve is interested in the physics of the most massive objects in the Universe and how we can use them to probe how the Universe evolved. Steve and his group are currently focused on understanding the astrophysics of galaxies and of galaxy clusters using multi-wavelength observations, and on using large, statistical samples of these objects to probe the natures of dark matter, dark energy and fundamental physics. More information regarding ongoing research and a list of Steve's current group members can be found here.

Kavli Institute
PRISM mentorsort ascending Research Interests

Susan Clark

Kavli Institute
Assistant Professor
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Kavli Institute

Last Updated: August 15, 2023

Susan is broadly interested in astrophysical magnetism and the physics of the interstellar medium (ISM), from diffuse gas to dense, star-forming regions. Susan’s research tackles open questions like the structure of the Milky Way’s magnetic field, the nature of interstellar turbulence and the multi-phase ISM, and the role of magnetism in star formation. These big questions demand multiwavelength observations and new data analysis techniques. Susan and her group decipher the magnetic ISM using a combination of theory and observation. Data-wise, the group uses a wide range of tracers including gas line emission and absorption, polarized dust and synchrotron emission, starlight polarization, Zeeman splitting, and Faraday rotation. Susan is involved in a number of current and future telescope projects, and leads several efforts focused on Galactic science with sensitive measurements of millimeter-wavelength emission made by cosmic microwave background experiments like the Atacama Cosmology Telescope (ACT) and the Simons Observatory (SO).

Susan Clark

Kavli Institute
Assistant Professor
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Kavli Institute

Last Updated: October 18, 2021

Susan is broadly interested in astrophysical magnetism and the physics of the interstellar medium (ISM), from diffuse gas to dense, star-forming regions. Susan’s research tackles open questions like the structure of the Milky Way’s magnetic field, the nature of interstellar turbulence, and the role of magnetism in star formation. These big questions demand multiwavelength observations and new data analysis techniques. Susan is particularly interested in deciphering the magnetic ISM using sensitive measurements of synchrotron and polarized dust emission made by cosmic microwave background experiments like the Atacama Cosmology Telescope (ACT) and the Simons Observatory (SO).

Steven Allen

Kavli Institute
Professor
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Kavli Institute

Last Updated: February 23, 2024

Steve is interested in the physics of the most massive objects in the Universe and how we can use them to probe how the Universe evolved. Steve and his group are currently focused on understanding the astrophysics of galaxies and of galaxy clusters using multi-wavelength observations, and on using large, statistical samples of these objects to probe the natures of dark matter, dark energy and fundamental physics. More information regarding ongoing research and a list of Steve's current group members can be found here.

Ophthalmology
PRISM mentorsort ascending Research Interests

Sui Wang

Ophthalmology
Assistant professor
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Ophthalmology

Last Updated: August 15, 2023

Our research focuses on unraveling the molecular mechanisms underlying retinal development and diseases. We employ genetic and genomic tools to explore how various retinal cell types, including neurons, glia, and the vasculature, respond to developmental cues and disease insults at the epigenomic and transcriptional levels. In addition, we investigate their interactions and collective contributions to maintain retinal integrity.

  • Other
Graduate School of Education
PRISM mentorsort ascending Research Interests

Subini Annamma

Graduate School of Education
Associate Professor
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Graduate School of Education

Last Updated: August 26, 2022

-education of Youth of Color, particularly focusing on processes of pushout, criminalization, and resistance, and racial and/or disability justice;

-experience with qualitative research in the humanistic social science tradition;

-commitment to the academic mentoring of undergraduate and graduate students as well as students from other groups underrepresented in education research;

-interdisciplinary and transdisciplinary work welcome including Black Studies, Ethnic Studies, Disability Studies, Women and Gender Studies, law, criminology, sociology, and Queer Studies.

 

  • Other
Pathology
PRISM mentorsort ascending Research Interests

Stephen Montgomery

Pathology
Associate Professor
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Pathology

Last Updated: April 15, 2021

We are looking for postdoctoral researchers interested in understanding the impact of rare variants on human diseases. Projects in the lab are either computational and experimental (or both!). We are particularly interested in establishing new research directions for using genomics data to interpret undiagnosed rare diseases. We are also interested in helping to improve the use of genetic data in diverse populations. Great opportunities for networking also as many of the projects in our lab are often part of major genomics research consortium like the UDN, Mendelian Genomics Research Centres, MoTrPAC, GTEx, TOPMED, ENCODE and more!

Please check out our website and our recent list of papers on Google Scholar https://scholar.google.com/citations?user=117h3CAAAAAJ&hl=en

  • Institutional Training Grant in Genome Science
  • Stanford Training Program in Aging Research
Genetics
PRISM mentorsort ascending Research Interests

Stephen Montgomery

Genetics
Associate Professor
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Genetics

Last Updated: April 15, 2021

We are looking for postdoctoral researchers interested in understanding the impact of rare variants on human diseases. Projects in the lab are either computational and experimental (or both!). We are particularly interested in establishing new research directions for using genomics data to interpret undiagnosed rare diseases. We are also interested in helping to improve the use of genetic data in diverse populations. Great opportunities for networking also as many of the projects in our lab are often part of major genomics research consortium like the UDN, Mendelian Genomics Research Centres, MoTrPAC, GTEx, TOPMED, ENCODE and more!

Please check out our website and our recent list of papers on Google Scholar https://scholar.google.com/citations?user=117h3CAAAAAJ&hl=en

  • Institutional Training Grant in Genome Science
  • Stanford Training Program in Aging Research
Med: Infectious Diseases
PRISM mentorsort ascending Research Interests

Stephen Luby

Med: Infectious Diseases
Professor
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Med: Infectious Diseases

Last Updated: August 09, 2021

Dr. Luby’s research group is engaged in several efforts to generate knowledge that will alter the way that bricks are manufactured across South Asia so that they generate less air pollution, less climate change and tens of thousands fewer deaths per year. This involves: 1) evaluating interventions to improve combustion efficiency within brick kilns and so simultaneously reduce coal costs for producers while generating less pollution 2) using remote sensing to specify the location of brick kilns and ultimately evaluate their emissions.

Another strand of his work looks at the release of lead into the environment in low and middle income countries, seeks to identify the sources of lead that is generating the greatest public health burden and develops and evaluates interventions to reduce this burden.

His research group also explores practical interventions to reduce infectious disease transmission in low and middle income countries. These activities include efforts to maximize the uptake of masks, water treatment and vaccines with careful evaluation of the impact of these interventions. His research group explores strategies to reduce the risk of pathogen transmission in healthcare facilities in lower income countries.

  • Applied Genomics in Infectious Diseases
  • Clinical Epidemiology of Infectious Diseases
Psyc: Behavioral Medicine
PRISM mentorsort ascending Research Interests

Stephanie Balters

Psyc: Behavioral Medicine
Instructor
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Psyc: Behavioral Medicine

Last Updated: February 08, 2024

Our goal is to understand how social factors such as interpersonal trauma and cultural biases impact brain function and mental health outcomes. With this knowledge, we develop evidence-based interventions to elevate work productivity, team performance, and well-being. We are passionate about embracing authenticity and vulnerability, and leveraging adverse experiences towards self-growth and achieving one’s full potential.

  • Research Training for Child Psychiatry and Neurodevelopment
Chemical Engineering
PRISM mentorsort ascending Research Interests

Stacey Bent

Chemical Engineering
Vice Provost for Graduate Education & Postdoctoral Affairs, Professor
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Chemical Engineering

Last Updated: July 14, 2022

The research in our laboratory is focused on understanding and controlling surface and interfacial chemistry and applying this knowledge to a range of problems in semiconductor processing, micro- and nanoelectronics, nanotechnology, and sustainable and renewable energy. Much of our research aims to develop a molecular-level understanding in these technologically important systems. Our group uses a variety of atomic and molecular spectroscopies combined with atomically-precise materials synthesis. Systems currently under study in our group include organic functionalization of semiconductor surfaces, mechanisms and control of atomic layer deposition, molecular layer deposition, area selective deposition processes, nanoscale materials for light absorption, interface engineering in photovoltaics and batteries, and catalyst and electrocatalyst synthesis and characterization.

Mechanical Engineering
PRISM mentorsort ascending Research Interests

Sindy Tang

Mechanical Engineering
Associate Professor
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Mechanical Engineering

Last Updated: January 27, 2024

From finger prick tests for blood glucose monitoring to industrial-scale drug screening in pharmaceutical companies, the ability to extract information from scarce volumes of samples quickly and cheaply is key to effective disease management and drug discovery. To this end, microfluidics offers major advantages over conventional liquid handling due to drastic reduction in reagent volume and the precise control of single cells, microtissues, and their microenvironments. The micro-nano-bio lab under the direction of Dr. Sindy Tang aims to develop innovative micro and nanoscale devices that harness mass transport phenomena to enable precise manipulation, measurement, and recapitulation of biological systems, in order to understand the "rules of life" and accelerate precision medicine and material design for a future with better health and environmental sustainability. Our approach involves building new tools to probe biological systems (from single cells to microtissues), and engineering smart materials, synthetic cells & tissues with properties that mimic some of the amazing properties biological systems have. Current research projects include:

 

  • Understanding and accelerating the diagnosis of allergic diseases
  • Biomechanics of single cell wound resilience
  • Tools for advancing cancer research
  • Bottom-up construction of biological systems

Sindy Tang

Mechanical Engineering
Associate Professor
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Mechanical Engineering

Last Updated: August 24, 2023

Postdoctoral Research Fellow – Cell biology & microfluidics, UCSF & Stanford

A joint postdoc position between the labs of Wallace Marshall (UCSF) and Sindy Tang (Stanford) is immediately available in the area of single-cell wound healing. The broad question we aim to answer is how the single-celled ciliate Stentor can heal drastic wounds. We are looking for a candidate with a background in cell biology or related fields. This position will allow ample opportunities to learn new techniques including microfluidics for single-cell manipulation and mathematical modeling. Application For questions or applications (see below), please feel free to reach out to Prof. Wallace Marshall (wallace.ucsf@gmail.com) or Prof. Sindy Tang (sindy@stanford.edu). To apply, please include a CV (with a publication list) and some detail about your background and interest in the project. Project description: Biomechanical mechanisms conferring wound resilience in single-celled organisms Stentor coeruleus is a large, single-celled ciliate that has remarkable wound healing and regenerative capacity (see Slabodnick et al., Current Bio, 2014 https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.10...). It is found in environments that can be subject to high mechanical stresses due to natural flows or predation. The overall goal of this project is to investigate how this organism employs both mechanical and biochemical mechanisms upstream of wounding for wound prevention, as well as downstream of wounding for robust healing from wounds (https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-021-00970-0).

We have sequenced the Stentor genome, and developed tools for molecular manipulation of Stentor gene expression to pave the way to a molecular understanding of Stentor wound response.   This project involves conceptualization of a novel chemical screen to test the role of the cytoskeleton in conferring wound resistance to the cell, and the role of large-scale mechanical force generation in complementing biochemical healing modes to close wounds of increasing severity.

Some questions we ask are: how does Stentor cell mechanics give rise to wound resistance? How do cells respond to shear or other types of stresses? What molecular pathways are important in Stentor wound healing, and are they the same as in other eukaryotes? The project combines cell biology, microfluidics for precise wounding (see Blauch et al., PNAS 2017 https://www.pnas.org/doi/abs/10.1073/pnas.1705059114), and mechanobiology modeling.

Required Qualifications: Desired skills for this project include: • Cell biology • Chemical screen • RNAi and genetic transformation • Past experience with Stentor, other ciliates, or manipulation (e.g., microinjection) of large cells or embryos such as Drosophila • Mathematical modelling of cellular processes Candidates proficient in certain skills outlined above will have opportunities to receive training in complementary skill sets.

Required Application Materials: Your CV with a publication list, and some detail about your background and interest in the project.

Sindy Tang

Mechanical Engineering
Associate Professor
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Mechanical Engineering

Last Updated: July 14, 2022

The micro-nano-bio lab under the direction of Prof. Sindy Tang aims to develop innovative micro and nanoscale devices that enable precise manipulation, measurement, and recapitulation of biological systems, in order to understand the "rules of life" and accelerate precision medicine and material design for a future with better health and environmental sustainability. Current projects include: food allergy diagnostics, single cell wound repair, microdissection of multicellular structures for organoids and spatial biology. Check out our website for latest updates.

Sindy Tang

Mechanical Engineering
Associate Professor
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Mechanical Engineering

Last Updated: February 10, 2023

Two postdoc positions in the lab of Prof. Sindy Tang are immediately available in the areas of microfluidics, nanofabrication, and spatial proteomics.

The spatial organization of proteins within biological tissues plays a critical role in the normal functioning of the tissue and disease development. The goal of this NIH-funded project is to develop a high throughput and scalable technology to perform tissue microdissection that preserves tissue spatial information and couples directly to established LC-MS/MS workflow for deep and unbiased spatial mapping of the proteome. Our approach integrates a novel tissue micro-dicing device, a nanodroplet sample preparation platform for LC-MS/MS analysis with single-cell sensitivity, and novel microfluidic device to transfer the diced tissue pixels while preserving their spatial order. This position will allow exciting opportunities to collaborate with the Pacific Northwest National Lab and the Stanford School of Medicine. 

The project is expected to accelerate MS-based spatial proteomics for deep and unbiased mapping of tissue heterogeneity down to single-cell resolution, thereby accelerating biomedical research and clinical diagnostics towards a better understanding of the role of tissue heterogeneity in pathophysiology, such as the role of the tumor microenvironment on cancer initiation and progression. The deep and unbiased proteome coverage will enable the discovery of novel protein biomarkers and molecular pathways to identify new therapeutic targets, which would be difficult using antibody-based approaches. Our ability to quantitatively map ECM and secreted proteins will facilitate the elucidation of the role of ECM, such as their remodeling, in disease progression. Finally, while this project focuses on spatial proteomics, we expect our technology and workflow to be extended to other biomolecules that LC-MS/MS can readily measure, such as lipids and metabolites, thereby opening the opportunity for spatial multi-omic measurements in future studies.

Skills useful for this project include: • Microfluidics design and integration, and related areas • Micro- and nanofabrication, e.g., silicon micromachining, high resolution 3D printing (e.g., Nanoscribe) • Experience working with biological samples (tissues)

Bioengineering
PRISM mentorsort ascending Research Interests

Sindy Tang

Bioengineering
Associate Professor
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Bioengineering

Last Updated: January 27, 2024

From finger prick tests for blood glucose monitoring to industrial-scale drug screening in pharmaceutical companies, the ability to extract information from scarce volumes of samples quickly and cheaply is key to effective disease management and drug discovery. To this end, microfluidics offers major advantages over conventional liquid handling due to drastic reduction in reagent volume and the precise control of single cells, microtissues, and their microenvironments. The micro-nano-bio lab under the direction of Dr. Sindy Tang aims to develop innovative micro and nanoscale devices that harness mass transport phenomena to enable precise manipulation, measurement, and recapitulation of biological systems, in order to understand the "rules of life" and accelerate precision medicine and material design for a future with better health and environmental sustainability. Our approach involves building new tools to probe biological systems (from single cells to microtissues), and engineering smart materials, synthetic cells & tissues with properties that mimic some of the amazing properties biological systems have. Current research projects include:

 

  • Understanding and accelerating the diagnosis of allergic diseases
  • Biomechanics of single cell wound resilience
  • Tools for advancing cancer research
  • Bottom-up construction of biological systems

Sindy Tang

Bioengineering
Associate Professor
View in Stanford Profiles

Bioengineering

Last Updated: August 24, 2023

Postdoctoral Research Fellow – Cell biology & microfluidics, UCSF & Stanford

A joint postdoc position between the labs of Wallace Marshall (UCSF) and Sindy Tang (Stanford) is immediately available in the area of single-cell wound healing. The broad question we aim to answer is how the single-celled ciliate Stentor can heal drastic wounds. We are looking for a candidate with a background in cell biology or related fields. This position will allow ample opportunities to learn new techniques including microfluidics for single-cell manipulation and mathematical modeling. Application For questions or applications (see below), please feel free to reach out to Prof. Wallace Marshall (wallace.ucsf@gmail.com) or Prof. Sindy Tang (sindy@stanford.edu). To apply, please include a CV (with a publication list) and some detail about your background and interest in the project. Project description: Biomechanical mechanisms conferring wound resilience in single-celled organisms Stentor coeruleus is a large, single-celled ciliate that has remarkable wound healing and regenerative capacity (see Slabodnick et al., Current Bio, 2014 https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.10...). It is found in environments that can be subject to high mechanical stresses due to natural flows or predation. The overall goal of this project is to investigate how this organism employs both mechanical and biochemical mechanisms upstream of wounding for wound prevention, as well as downstream of wounding for robust healing from wounds (https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-021-00970-0).

We have sequenced the Stentor genome, and developed tools for molecular manipulation of Stentor gene expression to pave the way to a molecular understanding of Stentor wound response.   This project involves conceptualization of a novel chemical screen to test the role of the cytoskeleton in conferring wound resistance to the cell, and the role of large-scale mechanical force generation in complementing biochemical healing modes to close wounds of increasing severity.

Some questions we ask are: how does Stentor cell mechanics give rise to wound resistance? How do cells respond to shear or other types of stresses? What molecular pathways are important in Stentor wound healing, and are they the same as in other eukaryotes? The project combines cell biology, microfluidics for precise wounding (see Blauch et al., PNAS 2017 https://www.pnas.org/doi/abs/10.1073/pnas.1705059114), and mechanobiology modeling.

Required Qualifications: Desired skills for this project include: • Cell biology • Chemical screen • RNAi and genetic transformation • Past experience with Stentor, other ciliates, or manipulation (e.g., microinjection) of large cells or embryos such as Drosophila • Mathematical modelling of cellular processes Candidates proficient in certain skills outlined above will have opportunities to receive training in complementary skill sets.

Required Application Materials: Your CV with a publication list, and some detail about your background and interest in the project.

Earth Energy Env Sciences
PRISM mentorsort ascending Research Interests

Simona Onori

Earth Energy Env Sciences
Associate Professor
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Earth Energy Env Sciences

Last Updated: February 23, 2024

Control Systems and Optimization 

Applied Math and Statistics 

Energy Storage Devices

Energy Conversion Devices

 

Geophysics
PRISM mentorsort ascending Research Interests

Simon Klemperer

Geophysics
Professor
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Geophysics

Last Updated: September 09, 2020
Earth & Planetary Sciences
PRISM mentorsort ascending Research Interests

Simon Klemperer

Earth & Planetary Sciences
Professor
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Earth & Planetary Sciences

Last Updated: September 09, 2020
SLAC National Accelerator Lab
PRISM mentorsort ascending Research Interests

Siegfried Glenzer

SLAC National Accelerator Lab
Professor
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SLAC National Accelerator Lab

Last Updated: February 23, 2024

X-ray laser physics; matter at extreme conditions and fusion research

  • Cancer Etiology, Prevention, Detection and Diagnosis
  • Postdoctoral Training in the Radiation Sciences
Med: Cardiovascular Medicine
PRISM mentorsort ascending Research Interests

Shoa Clarke

Med: Cardiovascular Medicine
Assistant Professor
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Med: Cardiovascular Medicine

Last Updated: August 28, 2023

The Clarke Lab uses genomics, epidemiology, and data science to understand cardiovascular disease risk. Key areas of focus include: 1. Equitable development and applications of polygenic risk scores

2. Novel phenotyping using electronic health records, wearables, and/or medical imaging

3.  Artificial intelligence applications to medical imaging

4. Studying nataionl biobanks (Million Veteran Program, UK Biobank, All of Us)

 

  • Cardiovascular Disease Prevention Training Program

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